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Found 31 with Last Name = 'vasta' and Initial = 'jd'
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50042876(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Affinity DataKi:  140nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50092609(CHEMBL3586252)
Affinity DataKi:  200nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataKi:  2.60E+3nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602487(CHEMBL5183286)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602490(CHEMBL5188399)
Affinity DataIC50:  2nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602490(CHEMBL5188399)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602489(CHEMBL5188250)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602489(CHEMBL5188250)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602489(CHEMBL5188250)
Affinity DataIC50:  8nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602487(CHEMBL5183286)
Affinity DataIC50:  32nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602490(CHEMBL5188399)
Affinity DataIC50:  47nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataIC50:  130nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602488(CHEMBL5199122)
Affinity DataIC50:  280nMAssay Description:Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602489(CHEMBL5188250)
Affinity DataIC50:  330nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50238177(CHEMBL4098072)
Affinity DataIC50:  330nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50042876(CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic...)
Affinity DataIC50:  840nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602488(CHEMBL5199122)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602488(CHEMBL5199122)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50092609(CHEMBL3586252)
Affinity DataIC50:  1.20E+3nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602490(CHEMBL5188399)
Affinity DataIC50:  6.70E+3nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProlyl 4-hydroxylase subunit alpha-1(Homo sapiens (Human))
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM26114(CHEMBL88972 | pyridine carboxylate, 6b | pyridine-...)
Affinity DataIC50:  1.50E+4nMpH: 7.8Assay Description:Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50:  1.50E+4nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602488(CHEMBL5199122)
Affinity DataIC50: >4.00E+4nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602487(CHEMBL5183286)
Affinity DataIC50: >4.00E+4nMAssay Description:Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50602487(CHEMBL5183286)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB