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Found 182 with Last Name = 'vermeulen' and Initial = 'np'
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50410855(CIN-QUIN | QUINIDEX | QUINIDINE SULFATE)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50185249(BS 7840 | CHEMBL380748)
Affinity DataIC50:  60nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataIC50:  94nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50185254(BS 7581 | CHEMBL444541)
Affinity DataIC50:  150nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50185248(CHEMBL203446 | GBR 12530)
Affinity DataIC50:  210nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50185257(BS 9106 | CHEMBL206647)
Affinity DataIC50:  260nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
Affinity DataIC50:  350nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM36108((R)-propranolol)
Affinity DataIC50:  420nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067028((1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067028((1E,4E)-1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataIC50:  610nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240380(2,6-Bis-(benzylidene)-cyclohexanone | 2,6-Bis-[1-p...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240380(2,6-Bis-(benzylidene)-cyclohexanone | 2,6-Bis-[1-p...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264832(2,6-bis(4-hydroxybenzylidene)cyclohexanone | CHEMB...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50116806(1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-4-(3-p...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D4(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50366613(DEXTROMETHORPHAN)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50367247(QUININE | Quinamm | Quinsan | cid_3034034)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM36108((R)-propranolol)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067044((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50241499(2,6-bis(4-(dimethylamino)benzylidene)cyclohexanone...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50241499(2,6-bis(4-(dimethylamino)benzylidene)cyclohexanone...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50241496(2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentan...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50241496(2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentan...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265082(1,5-bis(3-chlorophenyl)penta-1,4-dien-3-one | CHEM...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264887(2,6-bis(3-chlorobenzylidene)cyclohexanone | CHEMBL...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265082(1,5-bis(3-chlorophenyl)penta-1,4-dien-3-one | CHEM...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264887(2,6-bis(3-chlorobenzylidene)cyclohexanone | CHEMBL...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50366613(DEXTROMETHORPHAN)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240379((1E,4E)-1,5-Diphenyl-penta-1,4-dien-3-one | 1,5-di...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50240379((1E,4E)-1,5-Diphenyl-penta-1,4-dien-3-one | 1,5-di...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265040(1,5-bis(4-(trifluoromethyl)phenyl)penta-1,4-dien-3...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50265040(1,5-bis(4-(trifluoromethyl)phenyl)penta-1,4-dien-3...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264922(2,5-bis(4-hydroxybenzylidene)cyclopentanone | CHEM...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264922(2,5-bis(4-hydroxybenzylidene)cyclopentanone | CHEM...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D26(Rattus norvegicus)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50366613(DEXTROMETHORPHAN)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50185250(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264922(2,5-bis(4-hydroxybenzylidene)cyclopentanone | CHEM...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264922(2,5-bis(4-hydroxybenzylidene)cyclopentanone | CHEM...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50264886(2,6-bis(4-(trifluoromethyl)benzylidene)cyclohexano...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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