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TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555248(USRE49080, Example 16)
Affinity DataIC50:  0.150nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555251(USRE49080, Example 21)
Affinity DataIC50:  0.200nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555247(USRE49080, Example 15)
Affinity DataIC50:  0.200nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555242(USRE49080, Example 8)
Affinity DataIC50:  0.25nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555255(USRE49080, Example 28)
Affinity DataIC50:  0.330nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555263(USRE49080, Example 42)
Affinity DataIC50:  0.350nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555252(USRE49080, Example 22)
Affinity DataIC50:  0.400nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  0.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555250(USRE49080, Example 20)
Affinity DataIC50:  0.550nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555249(USRE49080, Example 17)
Affinity DataIC50:  0.800nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555270(USRE49080, Example 66)
Affinity DataIC50:  0.900nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555257(USRE49080, Example 31)
Affinity DataIC50:  1.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555271(USRE49080, Example 69)
Affinity DataIC50:  1.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555253(USRE49080, Example 24)
Affinity DataIC50:  1.30nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555245(USRE49080, Example 11)
Affinity DataIC50:  1.40nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555272(USRE49080, Example 71)
Affinity DataIC50:  1.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555254(USRE49080, Example 25)
Affinity DataIC50:  1.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555267(USRE49080, Example 60)
Affinity DataIC50:  2.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555238(USRE49080, Example 1)
Affinity DataIC50:  2.70nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555269(USRE49080, Example 65)
Affinity DataIC50:  2.70nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555264(USRE49080, Example 43)
Affinity DataIC50:  3.90nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555246(USRE49080, Example 14)
Affinity DataIC50:  5.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555243(USRE49080, Example 9)
Affinity DataIC50:  7.20nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555267(USRE49080, Example 60)
Affinity DataIC50:  9nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555259(USRE49080, Example 35)
Affinity DataIC50:  9.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555258(USRE49080, Example 33)
Affinity DataIC50:  11nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555239(USRE49080, Example 2)
Affinity DataIC50:  11.1nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555265(USRE49080, Example 46)
Affinity DataIC50:  14nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555261(USRE49080, Example 38)
Affinity DataIC50:  14.4nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555240(USRE49080, Example 3)
Affinity DataIC50:  16nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555262(USRE49080, Example 41)
Affinity DataIC50:  16.2nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555266(USRE49080, Example 47)
Affinity DataIC50:  16.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555244(USRE49080, Example 10)
Affinity DataIC50:  18nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555272(USRE49080, Example 71)
Affinity DataIC50:  19nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50560402(LIK-066 | Licogliflozin | Lik066 | USRE49080, Exam...)
Affinity DataIC50:  22nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555260(USRE49080, Example 36)
Affinity DataIC50:  28nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555271(USRE49080, Example 69)
Affinity DataIC50:  37nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555254(USRE49080, Example 25)
Affinity DataIC50:  40nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555264(USRE49080, Example 43)
Affinity DataIC50:  59nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555241(USRE49080, Example 4)
Affinity DataIC50:  65nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555256(USRE49080, Example 29)
Affinity DataIC50:  84.5nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555270(USRE49080, Example 66)
Affinity DataIC50:  100nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555263(USRE49080, Example 42)
Affinity DataIC50:  105nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555258(USRE49080, Example 33)
Affinity DataIC50:  157nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555269(USRE49080, Example 65)
Affinity DataIC50:  170nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555257(USRE49080, Example 31)
Affinity DataIC50:  404nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555249(USRE49080, Example 17)
Affinity DataIC50:  480nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555247(USRE49080, Example 15)
Affinity DataIC50:  650nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555238(USRE49080, Example 1)
Affinity DataIC50:  655nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM555242(USRE49080, Example 8)
Affinity DataIC50:  725nMAssay Description:The SGLT-2 assay is carried out as follows: CHO-hSGLT2 cells are cultivated in Ham's F12 Medium (BioWhittaker) with 10% foetal calf serum and 250...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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