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Found 128 with Last Name = 'waller' and Initial = 'd'
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194286(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-3-yl)oxazol-...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194278(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194292(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-4-yl)oxazol-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194301(4-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194284(5-(4-(4-(4-(3-fluorophenyl)oxazol-2-yl)phenoxy)phe...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194304(3-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194297(5-(2-ethoxyethyl)-5-(4-(4-(3-(pyridin-4-yl)-1,2,4-...)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194290(5-(4-(4-(4-(4-fluorophenyl)oxazol-2-yl)phenoxy)phe...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194285(3-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194289(5-(2-ethoxy-ethyl)-5-(4-{4-[4-(4-fluoro-phenyl)-ox...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194293(2-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194277(5-(2-ethoxyethyl)-5-(4-(4-(5-phenyl-1,2,4-oxadiazo...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194279(4-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194311(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194294(CHEMBL221806 | N-(3-fluorobenzyl)-4-(4-(5-(2-ethox...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194299(2-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194302(5-(2-ethoxyethyl)-5-(4-(4-(4-(2-fluorophenyl)oxazo...)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194288(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-2-yl)oxazol-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194282(5-(2-ethoxyethyl)-5-(4-(4-(3-(pyridin-2-yl)-1,2,4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194283(CHEMBL221751 | N-(2-fluorobenzyl)-4-(4-(5-(2-ethox...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194307(5-(4-(4-(4-(2-fluorophenyl)oxazol-2-yl)phenoxy)phe...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194310(5-(2-ethoxyethyl)-5-(4-(4-(3-phenylisoxazol-5-yl)p...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194305(5-(2-ethoxyethyl)-5-(4-(4-(2-phenyloxazol-5-yl)phe...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194308(5-(2-ethoxyethyl)-5-(4-(4-(3-(pyridin-3-yl)-1,2,4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194287(5-(2-ethoxyethyl)-5-(4-(4-(4-phenyloxazol-2-yl)phe...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194291(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50346961(CHEMBL1795875)
Affinity DataIC50:  3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194298(5-(2-ethoxyethyl)-5-(4-(4-(3-(2-fluorophenyl)-1,2,...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194296(CHEMBL218118 | N-(4-fluorobenzyl)-4-(4-(5-(2-ethox...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194295(5-(2-ethoxyethyl)-5-(4-(4-(3-phenyl-1,2,4-oxadiazo...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194303(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50098378((1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosp...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50098378((1-Hydroxy-1-phosphono-2-pyridin-2-yl-ethyl)-phosp...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human FPPS expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins in presence compound relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50434069(CHEMBL2381339 | US9676792, Compound 24)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assays were conducted at Invitrogen (Madison, Wis.) using the SelectScreen Kinase Profiling Service.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194300(5-(2-ethoxyethyl)-5-(4-(4-(3-(4-fluorophenyl)-1,2,...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194276(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194280(5-(2-ethoxyethyl)-5-(4-(4-(5-phenyloxazol-2-yl)phe...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194309(5-(2-ethoxyethyl)-5-(4-(4-(3-(3-fluorophenyl)-1,2,...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194281(CHEMBL374364 | N-benzyl-4-(4-(5-(2-ethoxyethyl)-2,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194312(5-(2-ethoxyethyl)-5-(4-(4-(5-phenyl-1,3,4-oxadiazo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585603(CHEMBL5087030)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585613(CHEMBL5088349)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM544004(US11279719, Example I-36)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50520641(CHEMBL4455060 | US11279719, Example I-13)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585614(CHEMBL5082193)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585601(CHEMBL5077349)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585611(CHEMBL5077117)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585604(CHEMBL5083916)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50585612(CHEMBL5089506)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant human N- terminal His-tagged /TEV cleavage site fused GGPPS (1 to 300 residues) expressed in Escherichia coli BL21 (DE3) us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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