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Found 102 with Last Name = 'walpita' and Initial = 'd'
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nM ΔG°: <-55.4kJ/mole IC50:  1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/mole IC50:  13nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/mole IC50:  19nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/mole IC50:  46nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  29nM ΔG°:  -43.0kJ/mole IC50:  64nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  37nM ΔG°:  -42.4kJ/mole IC50:  41nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  223nM ΔG°:  -38.0kJ/mole IC50:  147nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  500nM ΔG°:  -36.0kJ/mole IC50:  398nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  5.10E+3nM ΔG°:  -30.2kJ/mole IC50:  1.08E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  6.30E+3nM ΔG°:  -29.7kJ/mole IC50:  1.15E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  1.40E+4nM ΔG°:  -27.7kJ/mole IC50:  2.08E+3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188512((R)-4-(2-methoxyphenyl)-7,7-dimethyl-3-(trifluorom...)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188515((S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188511((S)-3,7,7-Trimethyl-4-(2-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM60933((S)-3,4,7,7-tetramethyl-4-phenyl-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188512((R)-4-(2-methoxyphenyl)-7,7-dimethyl-3-(trifluorom...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188511((S)-3,7,7-Trimethyl-4-(2-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188505(4-(2-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188515((S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7...)
Affinity DataIC50:  19nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM60933((S)-3,4,7,7-tetramethyl-4-phenyl-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  26nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188509(BRD3937 | US10137122, Compound 22)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188508(3,7,7-Trimethyl-4-(o-tolyl)-2,4,6,7,8,9-hexahydro-...)
Affinity DataIC50:  32nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM173196(4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-he...)
Affinity DataIC50:  39nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM173196(4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-he...)
Affinity DataIC50:  51nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188509(BRD3937 | US10137122, Compound 22)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188506(4-(3-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188505(4-(2-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataIC50:  87nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  92nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188508(3,7,7-Trimethyl-4-(o-tolyl)-2,4,6,7,8,9-hexahydro-...)
Affinity DataIC50:  102nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  106nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188503(3,7,7-trimethyl-4-(pyridin-3-yl)-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  119nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188503(3,7,7-trimethyl-4-(pyridin-3-yl)-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  153nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188506(4-(3-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataIC50:  156nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188498(3,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-...)
Affinity DataIC50:  201nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Broad Institute Of Harvard And Mit

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  231nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188498(3,7,7-trimethyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-...)
Affinity DataIC50:  236nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188502(3,7,7-trimethyl-4-(pyridin-2-yl)-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  255nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM188502(3,7,7-trimethyl-4-(pyridin-2-yl)-2,4,6,7,8,9-hexah...)
Affinity DataIC50:  319nMpH: 7.5 T: 2°CAssay Description:Purified GSK3beta was incubated with tested compounds in doses in the presence of 4.3 uM of ATP and 1.5uM peptide substrate (Peptide 15, Caliper, MA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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