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Found 119 with Last Name = 'wang' and Initial = 'wq'
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173375(CHEMBL3810248)
Affinity DataIC50:  59nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: <100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 3 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -80 mV resting membrane potential by electrophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173495(CHEMBL3809404)
Affinity DataIC50:  102nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173487(CHEMBL3809360)
Affinity DataIC50:  123nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173488(CHEMBL3810234)
Affinity DataIC50:  166nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173372(CHEMBL3808867)
Affinity DataIC50:  182nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173336(CHEMBL3808645)
Affinity DataIC50:  211nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173494(CHEMBL3810347 | US11629146, Compound 108)
Affinity DataIC50:  223nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  250nMAssay Description:Inhibition of Nav1.5 (unknown origin) assessed as inhibition of late sodium current by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  260nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 1 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173339(CHEMBL3809838)
Affinity DataIC50:  281nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  333nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  333nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173492(CHEMBL3809528)
Affinity DataIC50:  351nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173496(CHEMBL3809853)
Affinity DataIC50:  353nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173407(CHEMBL3809777)
Affinity DataIC50:  397nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  400nMAssay Description:Inhibition of 1 Hz stimulated Nav1.2 (unknown origin) by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  400nMAssay Description:Inhibition of 10 Hz stimulated Nav1.1 (unknown origin) by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173502(CHEMBL3809904)
Affinity DataIC50:  417nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173501(CHEMBL3809080)
Affinity DataIC50:  425nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 0.1 Hz frequency by manual patch clamp techniqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  600nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -120 mV resting membrane potential by electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173338(CHEMBL3808917)
Affinity DataIC50:  887nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173500(CHEMBL3810153)
Affinity DataIC50:  901nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173493(CHEMBL3809877)
Affinity DataIC50:  941nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of NaV1.7 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50213092((1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human potassium channel Kv1.5 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173135(CHEMBL3809641)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) assessed as inhibition of late sodium current by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of NaV1.8 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173498(CHEMBL3808625)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173489(CHEMBL3808737)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173302(CHEMBL3809055)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173135(CHEMBL3809641)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50361240(CHEMBL1934684)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 2(Rattus norvegicus)
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of rat potassium channel Kv4.2 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173340(CHEMBL3809812)
Affinity DataIC50:  2.22E+3nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily B member 1(Rattus norvegicus)
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50213094((1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholiny...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of rat potassium channel Kv2.1 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173143(CHEMBL3810355)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173241(CHEMBL3808641)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50361244(CHEMBL1934694)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173142(CHEMBL3810147)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of 3 Hz stimulated Nav1.5 (unknown origin) assessed as inhibition of peak sodium current by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily B member 1(Rattus norvegicus)
Cardiome Pharma

Curated by ChEMBL
LigandPNGBDBM50213092((1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cy...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of rat potassium channel Kv2.1 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50361243(CHEMBL1934693)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of NaV1.4 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173242(CHEMBL3808635)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173497(CHEMBL3808489)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of NaV1.1 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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