Compile Data Set for Download or QSAR
maximum 50k data
Found 50 with Last Name = 'wechsler-reya' and Initial = 'rj'
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522394(CHEMBL4472296)
Affinity DataIC50:  9nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50011478(ITRAZOLE)
Affinity DataIC50:  40nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50011478(ITRAZOLE)
Affinity DataIC50:  50nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522382(CHEMBL4450586)
Affinity DataIC50:  89nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522397(CHEMBL4440172)
Affinity DataIC50:  110nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522400(CHEMBL4562342)
Affinity DataIC50:  140nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50181473(4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)met...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522393(CHEMBL4572598)
Affinity DataIC50:  160nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522396(CHEMBL4447164)
Affinity DataIC50:  190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522373(CHEMBL4472335)
Affinity DataIC50:  190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522372(CHEMBL4473575)
Affinity DataIC50:  210nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522380(CHEMBL4562519)
Affinity DataIC50:  260nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522391(CHEMBL4462158)
Affinity DataIC50:  310nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522379(CHEMBL4583477)
Affinity DataIC50:  390nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522374(CHEMBL4471156)
Affinity DataIC50:  920nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522385(CHEMBL4455409)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522386(CHEMBL4543531)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522375(CHEMBL4473720)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522377(CHEMBL4571341)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522399(CHEMBL4456292)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522371(CHEMBL4565311)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522401(CHEMBL4541851)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50172714(CHEMBL3809786)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 10 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522398(CHEMBL4551142)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522395(CHEMBL4553424)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522392(CHEMBL4530520)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522390(CHEMBL4561019)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522389(CHEMBL4438128)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522388(CHEMBL4447193)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522387(CHEMBL4538569)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522384(CHEMBL4561378)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522383(CHEMBL4556073)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522381(CHEMBL4466705)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522378(CHEMBL4464304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522376(CHEMBL4448878)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50507787(CHEMBL4450683)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50507785(CHEMBL4587117)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50507786(CHEMBL4540110)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521013(CHEBI:17933 | Calcifediol)
Affinity DataEC50:  600nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521017(CHEMBL4524451)
Affinity DataEC50:  600nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521021(CHEMBL4439766)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521018(LG-190178)
Affinity DataEC50:  7.70nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521019(CHEMBL4449816)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  100nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50030475(7-Dehydrocholesterol | CHEBI:28940 | Cholecalcifer...)
Affinity DataEC50:  900nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521020(CHEMBL4459996)
Affinity DataEC50:  700nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521016(CHEMBL4438180)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521015(CHEMBL4580825)
Affinity DataEC50:  600nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521012(CHEMBL4522782)
Affinity DataEC50:  400nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50521014(CHEMBL4459512)
Affinity DataEC50:  100nMAssay Description:Activation of VDR in mouse ASZ001 cells assessed as change in Cyp24A1 mRNA expression after 48 hrs by q-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed