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Found 522 with Last Name = 'wen' and Initial = 'n'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50251208(CHEMBL4088272)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  20nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117522((5S,6R,9S)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  28nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  28nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589742(CHEMBL5173872)
Affinity DataKi:  39nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-xL (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  54nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  56nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  117nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50467780(CHEBI:5801 | Hydroxychloroquine | acs.jmedchem.1c0...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  158nMAssay Description:hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens)
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  170nMAssay Description:Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  224nMAssay Description:Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  247nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50117508((5S,6R,9R)-5-(4-Fluoro-phenyl)-9-(2-trifluoromethy...)
Affinity DataKi:  400nMAssay Description:Binding affinity of the compound to human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589726(CHEMBL5206019)
Affinity DataKi:  420nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589739(CHEMBL5197460)
Affinity DataKi:  460nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589731(CHEMBL5182327 | US11760752, Compound 38)
Affinity DataKi:  460nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  479nMAssay Description:Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50253157((+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-ph...)
Affinity DataKi:  479nMAssay Description:Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589724(CHEMBL5188517 | US11760752, Compound 31)
Affinity DataKi:  510nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589725(CHEMBL5209122)
Affinity DataKi:  530nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589727(CHEMBL5172723)
Affinity DataKi:  570nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589729(CHEMBL5176177)
Affinity DataKi:  600nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589728(CHEMBL5181405)
Affinity DataKi:  620nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589733(CHEMBL5183183 | US11760752, Compound 40)
Affinity DataKi:  660nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589737(CHEMBL5192774)
Affinity DataKi:  710nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589740(CHEMBL5192657)
Affinity DataKi:  710nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589741(CHEMBL5182219)
Affinity DataKi:  770nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50251208(CHEMBL4088272)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589736(CHEMBL5209295)
Affinity DataKi:  840nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589734(CHEMBL5203579)
Affinity DataKi:  900nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589735(CHEMBL5191785)
Affinity DataKi:  960nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589738(CHEMBL5180236)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50048866(1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-na...)
Affinity DataKi:  1.00E+3nMAssay Description:hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)

Curated by ChEMBL
LigandPNGBDBM50467780(CHEBI:5801 | Hydroxychloroquine | acs.jmedchem.1c0...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589730(CHEMBL5178609)
Affinity DataKi:  1.12E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589730(CHEMBL5178609)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589724(CHEMBL5188517 | US11760752, Compound 31)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of MCL-1 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50424732(CHEMBL2314209)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50589738(CHEMBL5180236)
Affinity DataKi:  1.22E+3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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