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Found 129 with Last Name = 'wessel' and Initial = 'md'
TargetEstrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.75nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24923(5-(carbamoylamino)-3-[(5R)-6,7,8,9-tetrahydro-5H-b...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24922(5-(carbamoylamino)-3-{6,7,8,9-tetrahydro-5H-benzo[...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataIC50:  1.12nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.18nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276129((2S,4bR,8aR)-4b-Ethyl-7-phenyl-4b,5,6,7,8,8a,9,10-...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276434((2R,4aR,10aR)-4a-Propyl-2-prop-1-ynyl-1,2,3,4,4a,9...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276127((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276438((2R,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylmeth...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175413(4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)pheno...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276126((2R,3S,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276437((2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-7-(pyridin-4-...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24899(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-[(methylca...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276472((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  3.30nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276171((2R,4aS,10aR)-4a-Propenyl-2-prop-1-ynyl-1,2,3,4,4a...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276128((2R,3R,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24901(3-{[(1R)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(me...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276170((2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-1,2,3,4,4a,9,...)
Affinity DataIC50:  5.60nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276475((2R,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylmeth...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276168((2R,4aR,10aR)-4a-Allyl-2-prop-1-ynyl-1,2,3,4,4a,9,...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276438((2R,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylmeth...)
Affinity DataIC50:  6.30nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24898(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(methylcar...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24919(3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-5...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175413(4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)pheno...)
Affinity DataIC50:  8.5nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24900(3-{[1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylc...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24918(5-(carbamoylamino)-3-[(5-chloro-2,3-dihydro-1H-ind...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175412(4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol | CHEM...)
Affinity DataIC50:  11.9nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276168((2R,4aR,10aR)-4a-Allyl-2-prop-1-ynyl-1,2,3,4,4a,9,...)
Affinity DataIC50:  14nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276170((2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-1,2,3,4,4a,9,...)
Affinity DataIC50:  14nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175417(4-(2-(3-methylisoxazol-4-yl)-1H-benzo[d]imidazol-1...)
Affinity DataIC50:  14.3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276472((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  15nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataIC50:  15.1nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24903(3-{[1-(4-chlorophenyl)-2-methylpropyl]sulfanyl}-5-...)
Affinity DataIC50:  16nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276169((2R,4aR,10aR)-4a-Methyl-2-prop-1-ynyl-1,2,3,4,4a,9...)
Affinity DataIC50:  17nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24910(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-3-...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276474((2R,4aR,10aR)-4a-Ethyl-2-phenyl-1,2,3,4,4a,9,10,10...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataIC50:  24nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24914(3-{[(2-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  28.1nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24911(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-(pyridin-3...)
Affinity DataIC50:  29nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  29.4nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276437((2R,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-7-(pyridin-4-...)
Affinity DataIC50:  31nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24909(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-2-...)
Affinity DataIC50:  33nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276168((2R,4aR,10aR)-4a-Allyl-2-prop-1-ynyl-1,2,3,4,4a,9,...)
Affinity DataIC50:  34nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as supression of NFkappaB-induced IL8 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276471((2R,3S,4aR,10aR)-4a-Ethyl-2-prop-1-ynyl-1,2,3,4,4a...)
Affinity DataIC50:  35nMAssay Description:Binding affinity to human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24904(3-{[1-(4-chlorophenyl)butyl]sulfanyl}-5-[(methylca...)
Affinity DataIC50:  35nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50276127((2R,3S,4aR,10aR)-4a-Ethyl-7-(2-methylpyridin-3-ylm...)
Affinity DataIC50:  38nMAssay Description:Transrepression activity at GR in human SW1353 cells assessed as inhibition of IL1-stimulated MMP13 production after 24 hrs by whole cell ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24913(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Affinity DataIC50:  45nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24915(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyrimidin-...)
Affinity DataIC50:  47nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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