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Found 246 with Last Name = 'yamazaki' and Initial = 'k'
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470581(5-Fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azab...)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470585(US10815241, Example 10 | US11369605, Example 10)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470582(US10815241, Example 7 | US11369605, Example 7)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470581(5-Fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azab...)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470578(US10815241, Example 3 | US11369605, Example 3)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470585(US10815241, Example 10 | US11369605, Example 10)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470582(US10815241, Example 7 | US11369605, Example 7)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470578(US10815241, Example 3 | US11369605, Example 3)
Affinity DataIC50: <3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470580(US10815241, Example 5 | US11369605, Example 5)
Affinity DataIC50:  4.10nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470580(US10815241, Example 5 | US11369605, Example 5)
Affinity DataIC50:  4.10nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM558847(2-[(4-{7-[(1S,3S,4R,6S)-6-(Cyclopropylmethyl)-2-az...)
Affinity DataIC50:  5.30nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470577(2-[(4-{7-[(1S,3S,4R,6S)-6-(Cyclopropylmethyl)-2-az...)
Affinity DataIC50:  5.30nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470584(US10815241, Example 9 | US11369605, Example 9)
Affinity DataIC50:  6.20nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470584(US10815241, Example 9 | US11369605, Example 9)
Affinity DataIC50:  6.20nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470586(US10815241, Example 11 | US11369605, Example 11)
Affinity DataIC50:  7nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470586(US10815241, Example 11 | US11369605, Example 11)
Affinity DataIC50:  7nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470579(US10815241, Example 4 | US11369605, Example 4)
Affinity DataIC50:  7.10nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470579(US10815241, Example 4 | US11369605, Example 4)
Affinity DataIC50:  7.10nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A/Menin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470583(US10815241, Example 8 | US11369605, Example 8)
Affinity DataIC50:  7.90nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMenin(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470583(US10815241, Example 8 | US11369605, Example 8)
Affinity DataIC50:  7.90nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170537(6-Phenoxymethyl-pyridine-2-carboxylic acid (3-hydr...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170540(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170480(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170475(6-Phenoxymethyl-pyridine-2-carboxylic acid (6-hydr...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170473(6-Phenoxymethyl-pyridine-2-carboxylic acid (4-hydr...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Rattus norvegicus (Rat))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112397(CHEMBL22323 | Sodium;4-chloro-N-{[(4-cyano-3-methy...)
Affinity DataIC50:  42nMAssay Description:Tested in vitro for inhibition of Endothelin-converting enzyme (ECE) of rat lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170491(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170491(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  74nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170500(10-{[6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-...)
Affinity DataIC50:  74nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170480(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  87nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170482(9-{[6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-p...)
Affinity DataIC50:  96nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170526(2-[3-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-be...)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170487(CHEMBL188333 | Quinoline-2-carboxylic acid (4-hydr...)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170502(6-Phenoxymethyl-pyridine-2-carboxylic acid (4-hydr...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170492(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170514(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  230nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170492(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170529(3-{[6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-p...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170547(({[6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-py...)
Affinity DataIC50:  270nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50178874(7-(2-hydroxy-3-(naphthalen-2-yloxy)propyl)-8-merca...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PDE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170550(4-(4-Chloro-phenoxy)-N-(4-hydroxycarbamoylmethyl-t...)
Affinity DataIC50:  320nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170561(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  350nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170554(1-Phenyl-1,4-dihydro-quinoline-4-carboxylic acid (...)
Affinity DataIC50:  380nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170501(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  390nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170511(CHEMBL366212 | N-(4-Hydroxycarbamoylmethyl-thiazol...)
Affinity DataIC50:  430nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170515((S)-2-{[6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethy...)
Affinity DataIC50:  460nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170501(6-(4-Acetyl-2-ethyl-5-hydroxy-phenoxymethyl)-pyrid...)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170479(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  520nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170531(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  620nMAssay Description:Inhibitory concentration against Phosphodiesterase type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170466(6-Phenoxymethyl-pyridine-2-carboxylic acid [4-(1-h...)
Affinity DataIC50:  630nMAssay Description:Inhibitory concentration against Phosphodiesterase type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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