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Found 238 with Last Name = 'yates' and Initial = 'k'
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190793(CHEMBL268939 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190791(CHEMBL210865 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190789(CHEMBL208565 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190784(CHEMBL378496 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190790(CHEMBL214195 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190794(CHEMBL211572 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  174nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190785(CHEMBL378349 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  188nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  310nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  511nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  580nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786((R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carb...)
Affinity DataKi:  628nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190788(CHEMBL378471 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  663nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190783(CHEMBL379302 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  962nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  1.66E+3nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Affinity DataKi:  4.54E+3nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215294(2-(N-(6-chloro-7-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor [538-972](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181020(US9133183, Example 29)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215283(2-(N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroqui...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215284(2-(N-(7-chloro-6-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589694(CHEMBL5170451)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589686(CHEMBL5197168)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589672(CHEMBL5176985)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-972](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181019(US9133183, Example 15)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589678(CHEMBL5181597)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589675(CHEMBL5176270)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589679(CHEMBL5170039)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589674(CHEMBL5186979)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589677(CHEMBL5174778)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589676(CHEMBL5177368)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215282(CHEMBL429296 | N-(6-chloro-7-methyl-2,3-dioxo-1,2,...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-972](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181027(US9133183, Example 90)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589675(CHEMBL5176270)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589676(CHEMBL5177368)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589681(CHEMBL5194023)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-972](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181018(US9133183, Example 1)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589689(CHEMBL5170609)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589692(CHEMBL5175832)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-972](Homo sapiens (Human))
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181034(US9133183, Example 91)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of His-tagged recombinant human FLT3 (564 to 958 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589687(CHEMBL5191635)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589688(CHEMBL5176187)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50215286(CHEMBL399275 | N-(6,7-dichloro-2,3-dioxo-1,2,3,4-t...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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