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Found 78 with Last Name = 'yoo' and Initial = 'hh'
TargetAromatase(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human aromatase using androstenedione as substrate assessed as estrone formation at 10 uM after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  3.30E+3nMAssay Description:Binding affinity towards human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human CYP2C8 using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation using paclitaxel as substrate incubated for 5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human CYP2C19 using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  6.20E+3nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation using phenacetin as substrate incubated for 5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50009647(BUTIN | CHEBI:27725)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human aromatase using androstenedione as substrate assessed as estrone formation at 10 uM after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human CYP2C9 using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317426(8-Gingerol | CHEMBL1095671)
Affinity DataIC50:  1.25E+4nMAssay Description:Binding affinity towards human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation using diclofenac as substrate incubated for 5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation using bupropion as substrate incubated for 5 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  1.63E+4nMAssay Description:Binding affinity towards human melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  1.76E+4nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  1.88E+4nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  1.96E+4nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237536(6-Shogaol | CHEBI:10138 | SHOGAOL | Trans-6-Shogao...)
Affinity DataIC50:  2.07E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  2.08E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50237535(6-Paradol | CHEBI:10137 | CHEMBL2071440)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human CYP1A2 using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataIC50:  2.18E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  2.18E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50275147(6-Gingerol | BDBM50317427 | CHEMBL446043 | Gingero...)
Affinity DataIC50:  2.21E+4nMAssay Description:In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50:  2.49E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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