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Found 197 with Last Name = 'yoon' and Initial = 'jh'
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of A disintegrin and metalloproteinase domain 9 (ADAM9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246252(CHEMBL521075 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317169((2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime | C...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317171((2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317163((2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime |...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246104(CHEMBL512174 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  4nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246145(CHEMBL471702 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317162((2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime |...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 12(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  5.93nMAssay Description:Inhibition of A disintegrin and metalloproteinase domain 12 (ADAM12) binding in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317177(5-nitroindirubin-3'-oxime | CHEMBL369303)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  7.5nMAssay Description:In vitro inhibition of A disintegrin and metalloproteinase domain 17 (ADAM17, TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246015(CHEMBL473301 | N-(3-chloro-4-methoxybenzyl)-7-chlo...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317170((2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime | ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  8.10nMAssay Description:In vitro inhibition of A disintegrin and metalloproteinase domain 10 (ADAM10)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317164((2'Z,3'E)-5-Trifluoromethoxy-5'-hydroxy-indirubin-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317173((2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime | C...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246199(CHEMBL488265 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317167((2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime | ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317166((2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime | ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246070(CHEMBL470310 | N-(3-chloro-4-methoxybenzyl)-8-ally...)
Affinity DataIC50:  12nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  12nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246069(4-(3-chloro-4-methoxybenzylamino)-8-allyl-6-nitroq...)
Affinity DataIC50:  12nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317161((2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK1/cyclin B after 40 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246148(CHEMBL470492 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  14nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246146(CHEMBL471703 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  14nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 12(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50156477(CHEMBL366034 | {3-(3-Bromo-phenyl)-2-[(furan-2-car...)
Affinity DataIC50:  16.7nMAssay Description:Inhibition of A disintegrin and metalloproteinase domain 12 (ADAM12) binding in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246197(CHEMBL520074 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  18nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246106(CHEMBL471529 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  18nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246107(CHEMBL471701 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  19nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246147(CHEMBL513593 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  19nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246251(CHEMBL488080 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  21nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294427(US9586959, Compound disclosed in WO 2010030785, Ex...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317165((2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime | C...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 12(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50156475(2-[2-[(5-Bromo-furan-2-carbonyl)-amino]-3-(4-bromo...)
Affinity DataIC50:  24.8nMAssay Description:Inhibition of A disintegrin and metalloproteinase domain 12 (ADAM12) binding in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294407(US9586959, Compound 69 | US9586959, Compound 95)
Affinity DataIC50:  27nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294407(US9586959, Compound 69 | US9586959, Compound 95)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at recombinant human histamine H4 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine induced st...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294418(US9586959, Compound 96)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataIC50:  29nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246105(CHEMBL471528 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  29nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246068(CHEMBL472558 | N-(3-chloro-4-methoxybenzyl)-7-meth...)
Affinity DataIC50:  32nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246198(CHEMBL488091 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  32nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294386(US9586959, Compound 49)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 12(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50156476(2-[2-Benzoylamino-3-(2-fluoro-phenyl)-acryloylamin...)
Affinity DataIC50:  40.5nMAssay Description:Inhibition of A disintegrin and metalloproteinase domain 12 (ADAM12) binding in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 12(Homo sapiens (Human))
Department Of Life Science And National Research Laboratory Of Proteolysis

Curated by ChEMBL
LigandPNGBDBM50156478(2-{2-[(Furan-2-carbonyl)-amino]-3-furan-2-yl-acryl...)
Affinity DataIC50:  42.3nMAssay Description:Inhibition of A disintegrin and metalloproteinase domain 12 (ADAM12) binding in cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294377(US9586959, Compound 29)
Affinity DataIC50:  52nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294415(US9586959, Compound 93)
Affinity DataIC50:  53nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM294361(US9586959, Compound 4)
Affinity DataIC50:  57nMAssay Description:Displacement of [3H]BRL 43694 from human recombinant 5-HT3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50317172((2'Z,3'E)-5-Trifluoromethoxy-5'-fluoro-indirubin-3...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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