Compile Data Set for Download or QSAR
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Found 108 with Last Name = 'zani' and Initial = 'm'
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50099646(5,6-dihydroxy-7-hydroxymethyl-3,11,11,14-tetrameth...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  0.450nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281601(13-butylcarbonyloxy-1,6-dihydroxy-8-hydroxymethyl-...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  0.800nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCepsilon by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099066(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Affinity DataKi:  4.90nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580096(CHEMBL5078146)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCalpha at 30 uM by scintillation counter method relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50057509((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...)
Affinity DataKi:  23nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCalpha by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50580095(CHEMBL5077090)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCepsilon by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50057509((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...)
Affinity DataKi:  40nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50057509((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...)
Affinity DataKi:  43nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50057509((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...)
Affinity DataKi:  70nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50580095(CHEMBL5077090)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-PDBu from recombinant human PKCalpha by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50057509((2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-1...)
Affinity DataKi:  114nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5 [D153N](Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50154254(CHEMBL3775705)
Affinity DataKi:  120nMAssay Description:Competitive inhibition of human KLK5 using Abz-KLRSSKQ-EDDnp as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5 [D153N](Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50154253(CHEMBL3775377)
Affinity DataKi:  130nMAssay Description:Competitive inhibition of human KLK5 using Abz-KLRSSKQ-EDDnp as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5 [D153N](Homo sapiens (Human))
Universidade Federal Fluminense

Curated by ChEMBL
LigandPNGBDBM50154252(CHEMBL3774934)
Affinity DataKi:  130nMAssay Description:Competitive inhibition of human KLK5 using Abz-KLRSSKQ-EDDnp as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099067(CHEMBL173348 | Dodecanoic acid (3S,3aR,8S,8aS)-3-h...)
Affinity DataKi:  150nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281600(7-hydroxymethyl-14-oxo-4-phenylcarbonyloxytricyclo...)
Affinity DataKi:  165nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50281846((2R,3R)-2-Hydroxymethyl-5-oxo-4-tridec-(E)-ylidene...)
Affinity DataKi:  200nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase CMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281846((2R,3R)-2-Hydroxymethyl-5-oxo-4-tridec-(E)-ylidene...)
Affinity DataKi:  200nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase C (alpha)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099064(CHEMBL368720 | Dodecanoic acid (3S,3aR,8R,8aS)-3-h...)
Affinity DataKi:  209nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099067(CHEMBL173348 | Dodecanoic acid (3S,3aR,8S,8aS)-3-h...)
Affinity DataKi:  228nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281602(4,5,6-trihydroxy-7-hydroxymethyl-3,11,11,14-tetram...)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]-PDBU from protein kinase C-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099065((3S,3aR,8R,8aS)-6-Dec-1-ynyl-3-hydroxymethyl-8-iso...)
Affinity DataKi:  279nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281845((2R,3R)-2-Hydroxymethyl-5-oxo-4-tridec-(E)-ylidene...)
Affinity DataKi:  300nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase C (alpha)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099067(CHEMBL173348 | Dodecanoic acid (3S,3aR,8S,8aS)-3-h...)
Affinity DataKi:  327nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50099064(CHEMBL368720 | Dodecanoic acid (3S,3aR,8R,8aS)-3-h...)
Affinity DataKi:  395nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099065((3S,3aR,8R,8aS)-6-Dec-1-ynyl-3-hydroxymethyl-8-iso...)
Affinity DataKi:  469nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50041403((2R,3R,4R)-2-Hydroxymethyl-5-oxo-4-tetradecyl-tetr...)
Affinity DataKi:  500nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase C (alpha)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099064(CHEMBL368720 | Dodecanoic acid (3S,3aR,8R,8aS)-3-h...)
Affinity DataKi:  515nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50099065((3S,3aR,8R,8aS)-6-Dec-1-ynyl-3-hydroxymethyl-8-iso...)
Affinity DataKi:  580nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099064(CHEMBL368720 | Dodecanoic acid (3S,3aR,8R,8aS)-3-h...)
Affinity DataKi:  593nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50281845((2R,3R)-2-Hydroxymethyl-5-oxo-4-tridec-(E)-ylidene...)
Affinity DataKi:  600nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase CMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50041403((2R,3R,4R)-2-Hydroxymethyl-5-oxo-4-tetradecyl-tetr...)
Affinity DataKi:  600nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase CMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281847((2R,3R,4S)-2-Hydroxymethyl-5-oxo-4-tetradecyl-tetr...)
Affinity DataKi:  600nMAssay Description:Inhibition of [20-3H]phorbol-12,13-dibutyrate (PDBU) binding to protein kinase C (alpha)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C alpha type(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50099067(CHEMBL173348 | Dodecanoic acid (3S,3aR,8S,8aS)-3-h...)
Affinity DataKi:  674nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099065((3S,3aR,8R,8aS)-6-Dec-1-ynyl-3-hydroxymethyl-8-iso...)
Affinity DataKi:  701nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099067(CHEMBL173348 | Dodecanoic acid (3S,3aR,8S,8aS)-3-h...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099064(CHEMBL368720 | Dodecanoic acid (3S,3aR,8R,8aS)-3-h...)
Affinity DataKi:  1.37E+3nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-chimaerin(Homo sapiens (Human))
University Of Tennessee College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50098227(CHEMBL275750 | Pentanoic acid 2-[4-(3-benzylamino-...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity of the compound towards beta chimerinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50099065((3S,3aR,8R,8aS)-6-Dec-1-ynyl-3-hydroxymethyl-8-iso...)
Affinity DataKi:  1.63E+3nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50098227(CHEMBL275750 | Pentanoic acid 2-[4-(3-benzylamino-...)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity for Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetotwn University

Curated by ChEMBL
LigandPNGBDBM50098227(CHEMBL275750 | Pentanoic acid 2-[4-(3-benzylamino-...)
Affinity DataKi:  2.70E+3nMAssay Description:Binding affinity for PKC-delta C1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591272(CHEMBL5208956)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant human full length DNA polymerase theta using DNA substrate measured after 1 hrs in presence of dNTPs by plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591280(CHEMBL5205456)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of recombinant human full length DNA polymerase theta using DNA substrate measured after 1 hrs in presence of dNTPs by plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591283(CHEMBL5190089)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of recombinant human full length DNA polymerase theta using DNA substrate measured after 1 hrs in presence of dNTPs by plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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