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Found 2030 with Last Name = 'zhu' and Initial = 'by'
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079482(Arginyl Ketomethylene analogue | CHEMBL410589)
Affinity DataKi:  0.000350nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079489(Arginyl Ketomethylene analogue | CHEMBL428116)
Affinity DataKi:  0.000570nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079476(Arginyl Ketomethylene analogue | CHEMBL437873)
Affinity DataKi:  0.000870nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079479(Arginyl Ketomethylene analogue | CHEMBL407043)
Affinity DataKi:  0.00150nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079485(Arginyl Ketomethylene analogue | CHEMBL414489)
Affinity DataKi:  0.00170nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079478(Arginyl Ketomethylene analogue | CHEMBL414760)
Affinity DataKi:  0.00200nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079491(Arginyl Ketomethylene analogue | CHEMBL412457)
Affinity DataKi:  0.00940nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142111(1-{4'-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)
Affinity DataKi:  0.0120nMAssay Description:Inhibitory concentration against coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Tested for binding affinity against human Coagulation factor Xa (trypsin-like serine protease)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124984((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataKi:  0.0130nMAssay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory activity of the compound against Coagulation factor Xa (serine protease) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079480(Arginyl Ketomethylene analogue | CHEMBL415375)
Affinity DataKi:  0.0350nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193861(5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimet...)
Affinity DataKi:  0.0440nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249120(CHEMBL472967 | N-(4-chloro-2-(5-chloropyridin-2-yl...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079488(Arginyl Ketomethylene analogue | CHEMBL414974)
Affinity DataKi:  0.0830nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
National Research Council Canada

Curated by ChEMBL
LigandPNGBDBM50079490(Arginyl Ketomethylene analogue | CHEMBL437999)
Affinity DataKi:  0.0830nMAssay Description:Inhibitory constant against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142112(2'-Dimethylamino-biphenyl-4-carboxylic acid [4-chl...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142090(2'-(N,N-Dimethyl-carbamimidoyl)-biphenyl-4-carboxy...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142125(2'-(Acetimidoylamino-methyl)-biphenyl-4-carboxylic...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory concentration against coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human JAK2 (828-1132) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142139(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-{4-[(N-methyl...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibitory activity against coagulation factor X.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249423(CHEMBL515919 | N-(2-(5-chloropyridin-2-ylcarbamoyl...)
Affinity DataKi:  0.105nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataKi:  0.117nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124975(2-[4-(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfon...)
Affinity DataKi:  0.170nMAssay Description:In vitro binding affinity towards factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113598((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataKi:  0.180nMAssay Description:Inhibitory activity of the compound against factor Xa,activity expressed as Ki nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human JAK1 (837-1142) expressed in baculovirus-infected Sf9 cells using EQEDEPEGDYFEWLE as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142118(2'-Amino-biphenyl-4-carboxylic acid [4-chloro-2-(5...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142129(2'-(4-Hydroxy-piperidin-1-yl)-biphenyl-4-carboxyli...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142169(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N'-dime...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142126(2'-Guanidinomethyl-biphenyl-4-carboxylic acid [4-c...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory concentration against coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142161(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-{[methyl-(...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140394(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142142(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N',N'-dim...)
Affinity DataKi:  0.300nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM99582(US8501936, 81)
Affinity DataKi:  0.300nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50363990(CHEMBL1949915)
Affinity DataKi:  0.400nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human GST-fused JAK3 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438673(CHEMBL2414535)
Affinity DataKi:  0.400nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataKi:  0.400nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142158(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-i...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438667(CHEMBL2414541)
Affinity DataKi:  0.5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140371(2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438666(CHEMBL2414542)
Affinity DataKi:  0.5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438670(CHEMBL2414538)
Affinity DataKi:  0.5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140388(2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347092(CHEMBL1796757)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as inhibition of PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438674(CHEMBL2414534)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438685(CHEMBL2414549)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50438688(CHEMBL2414544)
Affinity DataKi:  0.600nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142177(2-{4-[(Acetimidoyl-methyl-amino)-methyl]-benzoylam...)
Affinity DataKi:  0.600nMAssay Description:In vitro inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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