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Found 139 with Last Name = 'ziegler' and Initial = 'e'
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103345(US8546392, 69)
Affinity DataIC50:  7nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103342(US8546392, 64)
Affinity DataIC50:  10nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM103338(US8546392, 59)
Affinity DataIC50:  14nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | N-{3-[2-Hydroxy-6-(3-hydroxyphenyl...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103338(US8546392, 59)
Affinity DataIC50:  20nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50261942(6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol | CHEMBL46...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human placental 17beta-HSD1 assessed as conversion of [3H]estrone to [3H]17beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103336(US8546392, 57)
Affinity DataIC50:  20nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50261942(6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol | CHEMBL46...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | N-{3-[2-Hydroxy-6-(3-hydroxyphenyl...)
Affinity DataIC50:  23nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103346(US8546392, 70)
Affinity DataIC50:  30nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103346(US8546392, 70)
Affinity DataIC50:  30nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  33nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335820(6-(3-Hydroxyphenyl)-1-(pyridin-4-yl)-2-naphthol | ...)
Affinity DataIC50:  39nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103337(US8546392, 58)
Affinity DataIC50:  40nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50261887(1-Bromo-6-(3-hydroxyphenyl)-2-naphthol | CHEMBL467...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human placental 17beta-HSD1 assessed as conversion of [3H]estrone to [3H]17beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103340(US8546392, 62)
Affinity DataIC50:  50nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  50nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103344(US8546392, 68)
Affinity DataIC50:  50nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50179201(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human placental 17beta-HSD1More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335819(1-(3-Aminophenyl)-6-(3-hydroxyphenyl)-2-naphthol |...)
Affinity DataIC50:  53nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103347(US8546392, 71)
Affinity DataIC50:  60nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335820(6-(3-Hydroxyphenyl)-1-(pyridin-4-yl)-2-naphthol | ...)
Affinity DataIC50:  64nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335821(1-(3-Furyl)-6-(3-hydroxyphenyl)-2-naphthol | CHEMB...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103334(US8546392, 19)
Affinity DataIC50:  70nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335815(CHEMBL1650658 | N-{3-[2-Hydroxy-6-(3-hydroxyphenyl...)
Affinity DataIC50:  71nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103339(US8546392, 60)
Affinity DataIC50:  90nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103343(US8546392, 66)
Affinity DataIC50:  114nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  115nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50168371(6-(3-Hydroxy-phenyl)-naphthalen-2-ol | 6-(3-hydrox...)
Affinity DataIC50:  116nMAssay Description:Inhibition of human placental 17beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50168371(6-(3-Hydroxy-phenyl)-naphthalen-2-ol | 6-(3-hydrox...)
Affinity DataIC50:  116nMAssay Description:Inhibition of human placental 17beta-HSD1 assessed as conversion of [3H]estrone to [3H]17beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50168371(6-(3-Hydroxy-phenyl)-naphthalen-2-ol | 6-(3-hydrox...)
Affinity DataIC50:  116nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103341(US8546392, 63)
Affinity DataIC50:  140nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103338(US8546392, 59)
Affinity DataIC50:  150nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  165nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM103346(US8546392, 70)
Affinity DataIC50:  195nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM103338(US8546392, 59)
Affinity DataIC50:  221nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  224nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50168371(6-(3-Hydroxy-phenyl)-naphthalen-2-ol | 6-(3-hydrox...)
Affinity DataIC50:  229nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50090677(4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfon...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 1A2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  259nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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