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Found 47 with Last Name = 'zuccarello' and Initial = 'g'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM348((2R,3R,4R,5R)-2,5-bis(benzyloxy)-3,4-dihydroxy-N,N...)
Affinity DataKi:  0.800nM ΔG°:  -52.8kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1166((4R,5S,6S,7R)-1,3-Bis{[4-(hydroxymethyl)phenyl]met...)
Affinity DataKi: <1nM ΔG°: <-53.4kJ/mole IC50:  10nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM150((4R,5S,6S,7R)-4,7-dibenzyl-5,6-dihydroxy-1,3-bis({...)
Affinity DataKi: <1nM ΔG°: <-53.4kJ/mole IC50:  15nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM353((2R,3R,4R,5R)-2,5-bis[(2,4-difluorophenyl)methoxy]...)
Affinity DataKi:  1.12nM ΔG°:  -51.9kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM358((2R,3R,4R,5R)-2,5-bis(benzyloxy)-3,4-dihydroxy-N,N...)
Affinity DataKi:  1.22nM ΔG°:  -51.7kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM352((2R,3R,4R,5R)-2,5-bis[(2,3-difluorophenyl)methoxy]...)
Affinity DataKi:  1.28nM ΔG°:  -51.6kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM365((2R,3R,4R,5R)-2,5-bis[(2,6-difluorophenyl)methoxy]...)
Affinity DataKi:  1.64nM ΔG°:  -51.0kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM363((2R,3R,4R,5R)-2,5-bis[(2,4-difluorophenyl)methoxy]...)
Affinity DataKi:  1.65nM ΔG°:  -51.0kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM355((2R,3R,4R,5R)-2,5-bis[(2,6-difluorophenyl)methoxy]...)
Affinity DataKi:  1.73nM ΔG°:  -50.8kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM351((2R,3R,4R,5R)-2,5-bis[(4-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  1.79nM ΔG°:  -50.8kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM350((2R,3R,4R,5R)-2,5-bis[(3-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  1.83nM ΔG°:  -50.7kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM349((2R,3R,4R,5R)-2,5-bis[(2-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  1.92nM ΔG°:  -50.6kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM357((2R,3R,4R,5R)-2,5-bis[(3,5-difluorophenyl)methoxy]...)
Affinity DataKi:  1.98nM ΔG°:  -50.5kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM354((2R,3R,4R,5R)-2,5-bis[(2,5-difluorophenyl)methoxy]...)
Affinity DataKi:  1.98nM ΔG°:  -50.5kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM356((2R,3R,4R,5R)-2,5-bis[(3,4-difluorophenyl)methoxy]...)
Affinity DataKi:  1.98nM ΔG°:  -50.5kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM359((2R,3R,4R,5R)-2,5-bis[(2-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  3.26nM ΔG°:  -49.3kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM364((2R,3R,4R,5R)-2,5-bis[(2,5-difluorophenyl)methoxy]...)
Affinity DataKi:  3.29nM ΔG°:  -49.2kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM366((2R,3R,4R,5R)-2,5-bis[(3,4-difluorophenyl)methoxy]...)
Affinity DataKi:  3.90nM ΔG°:  -48.8kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM362((2R,3R,4R,5R)-2,5-bis[(2,3-difluorophenyl)methoxy]...)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM367((2R,3R,4R,5R)-2,5-bis[(3,5-difluorophenyl)methoxy]...)
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM361((2R,3R,4R,5R)-2,5-bis[(4-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  5.39nM ΔG°:  -48.0kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM360((2R,3R,4R,5R)-2,5-bis[(3-fluorophenyl)methoxy]-3,4...)
Affinity DataKi:  7.13nM ΔG°:  -47.3kJ/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1157((4R,5S,6S,7R)-1,3-Dibenzyl-4,7-bis(phenoxymethyl)-...)
Affinity DataKi:  12.2nM ΔG°:  -47.0kJ/mole IC50:  80nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1164((3R,4S,5S,6R)-2,7-Dibenzyl-3,6-bis(2-phenylethyl)-...)
Affinity DataKi:  14.7nM ΔG°:  -46.5kJ/mole IC50:  200nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1163((3R,4S,5S,6R)-2,7-Dibenzyl-3,6-bis(phenoxymethyl)-...)
Affinity DataKi:  19.1nM ΔG°:  -45.8kJ/mole IC50:  200nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1161((4R,5S,6S,7R)-1,3-Dibenzyl-4,7-bis(2-phenylethyl)-...)
Affinity DataKi:  214nM ΔG°:  -39.6kJ/mole IC50:  4.00E+3nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1162((4R,5S,6S,7R)-1,3-Dibenzyl-4,7-bis(3-phenylpropyl)...)
Affinity DataKi:  570nM ΔG°:  -37.1kJ/mole IC50:  1.00E+4nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087827(CHEMBL49082 | Cyclopent-2-ene-1,2-dicarboxylic aci...)
Affinity DataIC50:  870nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087834(CHEMBL50117 | Cyclopent-2-ene-1,2-dicarboxylic aci...)
Affinity DataIC50:  890nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087840(CHEMBL298122 | Cyclopent-2-ene-1,2-dicarboxylic ac...)
Affinity DataIC50:  980nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087837(CHEMBL45692 | Cyclopentane-1,2-dicarboxylic acid 1...)
Affinity DataIC50:  1.32E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087830(CHEMBL49808 | Cyclopent-2-ene-1,2-dicarboxylic aci...)
Affinity DataIC50:  1.51E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM29388(Exanta | Melagatran | US11584714, Compound 999)
Affinity DataIC50:  4.70E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50125869(CHEMBL416904 | Cyclopent-2-ene-1,2-dicarboxylic ac...)
Affinity DataIC50:  4.90E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087829(2-(Piperidine-1-carbonyl)-cyclopent-2-enecarboxyli...)
Affinity DataIC50:  6.03E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1165((4R,5S,6S,7R)-1,3-Bis{[4-(methoxycarbonyl)phenyl]m...)
Affinity DataIC50:  8.00E+3nMpH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087833(CHEMBL298879 | Cyclopent-2-ene-1,2-dicarboxylic ac...)
Affinity DataIC50:  9.33E+3nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50125871(CHEMBL17646 | Cyclopent-2-ene-1,2-dicarboxylic aci...)
Affinity DataIC50:  1.12E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087832(CHEMBL289840 | Cyclopentane-1,2-dicarboxylic acid ...)
Affinity DataIC50:  1.32E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087828(CHEMBL433275 | {[2-(4-Carbamimidoyl-benzylcarbamoy...)
Affinity DataIC50:  2.04E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50073316(CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...)
Affinity DataIC50:  2.24E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087831((-) Cyclopentane-1,2-dicarboxylic acid 1-benzylami...)
Affinity DataIC50:  4.47E+4nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087836(CHEMBL49050 | {[2-(4-Carbamimidoyl-benzylcarbamoyl...)
Affinity DataIC50: >1.32E+5nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Link£Ping University

Curated by ChEMBL
LigandPNGBDBM50087842((+) Cyclopentane-1,2-dicarboxylic acid 1-benzylami...)
Affinity DataIC50: >1.32E+5nMAssay Description:In vitro for the inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1158((4S,5R,6R,7S)-1,3-Dibenzyl-4,7-bis(phenoxymethyl)-...)
Affinity DatapH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1159((4S,5S,6S,7S)-1,3-Dibenzyl-4,7-bis(phenoxymethyl)-...)
Affinity DatapH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University

LigandPNGBDBM1160((4R,5R,6R,7R)-1,3-Dibenzyl-4,7-bis(phenoxymethyl)-...)
Affinity DatapH: 5.5 T: 2°CAssay Description:The IC50 value is the inhibitor concentration that results in 50% of HIV-1 protease activity measured by a spectrophotometric assay using a chromopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed