Found 64 with Last Name = 'da silva' and Initial = 'ef' TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity to Trypanosoma brucei rhodesainMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibition of West Nile virus NS2B (47 residues)-NS3 (184 residues) protease expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins follow...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of Dengue virus serotype 1 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of Dengue virus serotype 1 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of Dengue virus serotype 1 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of Dengue virus serotype 1 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 430nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
Affinity DataKi: 470nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of Dengue virus serotype 3 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of Dengue virus serotype 3 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibition of Dengue virus serotype 3 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of Dengue virus serotype 3 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of Dengue virus serotype 4 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 2.20E+3nMAssay Description:Inhibition of Dengue virus serotype 4 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 2.20E+3nMAssay Description:Inhibition of Dengue virus serotype 4 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of Dengue virus serotype 4 NS2B-NS3 protease preincubated for 20 mins followed by Abz-RRRRSAG-nY-NH2 addition and measured for 60 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated for 15 mins followed by Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr addition and measured...More data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nMAssay Description:Inhibition of West Nile virus NS2B-NS3 protease preincubated for 1 hr followed by Pyr-RTKR-AMC addition and measured after 30 mins by fluorescence me...More data for this Ligand-Target Pair
Affinity DataKi: 8.00E+3nMAssay Description:Inhibition of West Nile virus NS2B-NS3 protease preincubated for 10 mins followed by Np-KKR-pNA addition and measured every 5 secs for 2 mins by fluo...More data for this Ligand-Target Pair
Affinity DataKi: 1.21E+4nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease expressed in Escherichia coli C41 cells preincubated for 15 mins followed by GRR-AMC addition...More data for this Ligand-Target Pair
Affinity DataKi: 9.25E+4nMAssay Description:Inhibition of West Nile virus NS2B-NS3 protease preincubated for 15 mins followed by Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr addition and measured for...More data for this Ligand-Target Pair
TargetmRNA cap guanine-N7 methyltransferase(Homo sapiens)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of human guanine-N7 methyltransferase expressed in Saccharomyces cerevisiae YBS40 (MATa leu2 ade2 trp1 his3 ura3 can1 abd1::hisGp360-ABD1)More data for this Ligand-Target Pair
3D Structure (crystal)TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
TargetmRNA cap guanine-N7 methyltransferase(Homo sapiens)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: <50nMAssay Description:Inhibition of N-terminus hexa-histidine tagged-human guanine-N7 methyltransferase expressed in Escherichia coli using GpppAC4 RNA as substrate incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of West Nile virus proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of spike protein in SARS-CoV infected in human HeLa cells haboring wild type ACE2 assessed as reduction in virus infectivity preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of Zika virus IbH_30656 NS2B (45 to 96 residues)-NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21/Rosetta (DE3) cells p...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of N-terminal His6-SUMO tagged Zika virus Puerto Rico NS2B-NS3 linked protease expressed in Escherichia coli BL21 Codon Plus (DE3) cells p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of N-terminal His6-SUMO tagged Zika virus Puerto Rico NS2B-NS3 unlinked protease expressed in Escherichia coli BL21 Codon Plus (DE3) cells...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of N-terminal His6-SUMO tagged Zika virus Puerto Rico NS2B-NS3 unlinked protease expressed in Escherichia coli BL21 Codon Plus (DE3) cells...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B(40 residues)-NS3 (185 residues) protease preincubated for 30 mins followed by ABz-nKRR-AMC addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of West Nile virus NS2B-NS3 protease preincubated for 1 hr followed by Pyr-RTKR-AMC addition and measured after 30 mins by fluorescence me...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to controlMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University Of Alagoas
Curated by ChEMBL
Federal University Of Alagoas
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
