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There are 12 purchasable compounds for target: CDK4/Cyclin D

Compile data set for download or QSAR
Wt: 447.5
BDBM6309
Purchase
Wt: 364.4
BDBM6245
Purchase
Wt: 298.3
BDBM6640
Wt: 294.2
BDBM6643
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Wt: 312.2
BDBM6645
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Wt: 306.3
BDBM6635
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Wt: 314.3
BDBM6637
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Wt: 260.2
BDBM6639
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Wt: 253.2
BDBM6644
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Wt: 213.2
BDBM6659
Purchase
Wt: 219.2
BDBM6661
Purchase
Wt: 303.3
BDBM7451
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 6309,6245,6640,6643,6645,6635,6637,6639,6644,6659,6661,7451   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6245
PNG
(8-Ethyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-...)
Show SMILES CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2ccc1=O
Show InChI InChI=1S/C20H24N6O/c1-3-26-18(27)9-4-15-14-21-20(23-19(15)26)22-16-5-7-17(8-6-16)25-12-10-24(2)11-13-25/h4-9,14H,3,10-13H2,1-2H3,(H,21,22,23)
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PubMed
n/an/a 85n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...


J Med Chem 43: 4606-16 (2000)


Article DOI: 10.1021/jm000271k
BindingDB Entry DOI: 10.7270/Q25B00N4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6309
PNG
(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Show SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O
Show InChI InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
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n/an/a 11n/an/an/an/an/an/a



Pfizer



Assay Description
The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...


J Med Chem 48: 2388-406 (2005)


Article DOI: 10.1021/jm049354h
BindingDB Entry DOI: 10.7270/Q21J97Z9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM7451
PNG
(1-{12-hydroxy-3-phenyl-8-oxa-6-azatricyclo[7.4.0.0...)
Show SMILES CC(=O)c1cnc2oc3ccc(O)cc3c2c1-c1ccccc1
Show InChI InChI=1S/C19H13NO3/c1-11(21)15-10-20-19-18(17(15)12-5-3-2-4-6-12)14-9-13(22)7-8-16(14)23-19/h2-10,22H,1H3
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n/an/a>1.00E+5n/an/an/an/a7.230



Martin-Luther-University Halle-Wittenberg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 15: 823-5 (2005)


Article DOI: 10.1016/j.bmcl.2004.10.091
BindingDB Entry DOI: 10.7270/Q2QZ2853
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6635
PNG
(1-[2-(dimethylamino)quinolin-4-yl]-3-phenylurea | ...)
Show SMILES CN(C)c1cc(NC(=O)Nc2ccccc2)c2ccccc2n1
Show InChI InChI=1S/C18H18N4O/c1-22(2)17-12-16(14-10-6-7-11-15(14)20-17)21-18(23)19-13-8-4-3-5-9-13/h3-12H,1-2H3,(H2,19,20,21,23)
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n/an/a 9.00E+4n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6637
PNG
(1,3-bis(quinolin-6-yl)urea | Diarylurea 4)
Show SMILES O=C(Nc1ccc2ncccc2c1)Nc1ccc2ncccc2c1
Show InChI InChI=1S/C19H14N4O/c24-19(22-15-5-7-17-13(11-15)3-1-9-20-17)23-16-6-8-18-14(12-16)4-2-10-21-18/h1-12H,(H2,22,23,24)
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n/an/a 7.70E+4n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6661
PNG
(1-cyclohexyl-3-pyridin-2-ylurea | Diarylurea deriv...)
Show SMILES O=C(NC1CCCCC1)Nc1ccccn1
Show InChI InChI=1S/C12H17N3O/c16-12(14-10-6-2-1-3-7-10)15-11-8-4-5-9-13-11/h4-5,8-10H,1-3,6-7H2,(H2,13,14,15,16)
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n/an/a>1.00E+5n/an/an/an/an/a30



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6640
PNG
(5-[(2-hydroxynaphthalen-1-yl)methylidene]-2-sulfan...)
Show SMILES Oc1ccc2ccccc2c1C=C1C(=O)NC(=S)NC1=O
Show InChI InChI=1S/C15H10N2O3S/c18-12-6-5-8-3-1-2-4-9(8)10(12)7-11-13(19)16-15(21)17-14(11)20/h1-7,18H,(H2,16,17,19,20,21)
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n/an/a 1.00E+5n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6643
PNG
(2-amino-4-(2H-1,3-benzodioxol-5-yl)-6-methoxypyrid...)
Show SMILES COc1nc(N)c(C#N)c(-c2ccc3OCOc3c2)c1C#N
Show InChI InChI=1S/C15H10N4O3/c1-20-15-10(6-17)13(9(5-16)14(18)19-15)8-2-3-11-12(4-8)22-7-21-11/h2-4H,7H2,1H3,(H2,18,19)
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n/an/a 3.60E+4n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6644
PNG
(6‐phenylpteridine‐2,4,7‐triamine...)
Show SMILES Nc1nc(N)c2nc(c(N)nc2n1)-c1ccccc1
Show InChI InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
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n/an/a 2.10E+5n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6645
PNG
(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}b...)
Show SMILES Nc1nc2ncc(CNc3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
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n/an/a 1.60E+4n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6659
PNG
(1-phenyl-3-pyridin-2-ylurea | Diarylurea deriv. 14...)
Show SMILES O=C(Nc1ccccc1)Nc1ccccn1
Show InChI InChI=1S/C12H11N3O/c16-12(14-10-6-2-1-3-7-10)15-11-8-4-5-9-13-11/h1-9H,(H2,13,14,15,16)
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n/an/a 1.00E+5n/an/an/an/an/a30



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM6639
PNG
(5-(2H-1,3-benzodioxol-5-ylmethylidene)-1,3-diazina...)
Show SMILES O=C1NC(=O)C(=Cc2ccc3OCOc3c2)C(=O)N1
Show InChI InChI=1S/C12H8N2O5/c15-10-7(11(16)14-12(17)13-10)3-6-1-2-8-9(4-6)19-5-18-8/h1-4H,5H2,(H2,13,14,15,16,17)
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n/an/a 3.50E+5n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4615-27 (2001)


Article DOI: 10.1021/jm0103256
BindingDB Entry DOI: 10.7270/Q2736P3Q
More data for this
Ligand-Target Pair