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21 similar compounds to monomer 50433592

Compile data set for download or QSAR
Wt: 515.5
BDBM100827
Wt: 511.4
BDBM100857
Wt: 543.5
BDBM100837
Wt: 489.4
BDBM100800
Wt: 475.5
BDBM100831
Wt: 519.5
BDBM100838
Wt: 489.4
BDBM100843
Wt: 503.5
BDBM50433576
Wt: 503.5
BDBM50433577
Purchase
Wt: 489.4
BDBM50433579
Wt: 478.5
BDBM50433580
Wt: 432.4
BDBM50433582
Wt: 407.4
BDBM50433583
Wt: 421.4
BDBM50433584
Wt: 461.4
BDBM50433586
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 100827,100857,100837,100800,100831,100838,100843,50433576,50433577,50433579,50433580,50433582,50433583,50433584,50433586   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon


(Homo sapiens (Human))
BDBM100827
PNG
(US8507533, 138 | US8507533, 151 | US8507533, 374)
Show SMILES Cc1cc(OC(C2CCC2)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-n1cc(cn1)C(F)(F)F
Show InChI InChI=1/C27H28F3N3O4/c1-16-12-22(13-17(2)24(16)33-15-21(14-32-33)27(28,29)30)37-25(18-4-3-5-18)19-6-8-20(9-7-19)26(36)31-11-10-23(34)35/h6-9,12-15,18,25H,3-5,10-11H2,1-2H3,(H,31,36)(H,34,35)
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5.75n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433577
PNG
(CHEMBL2381848)
Show SMILES CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/s2
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14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100827
PNG
(US8507533, 138 | US8507533, 151 | US8507533, 374)
Show SMILES Cc1cc(OC(C2CCC2)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-n1cc(cn1)C(F)(F)F
Show InChI InChI=1/C27H28F3N3O4/c1-16-12-22(13-17(2)24(16)33-15-21(14-32-33)27(28,29)30)37-25(18-4-3-5-18)19-6-8-20(9-7-19)26(36)31-11-10-23(34)35/h6-9,12-15,18,25H,3-5,10-11H2,1-2H3,(H,31,36)(H,34,35)
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20.2n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100838
PNG
(US8507533, 153)
Show SMILES CCCC(Oc1cc(C)c(c(OC)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H28F3N3O5/c1-4-5-21(17-6-8-18(9-7-17)25(35)30-11-10-23(33)34)37-20-12-16(2)24(22(13-20)36-3)32-15-19(14-31-32)26(27,28)29/h6-9,12-15,21H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)
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32.3n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100837
PNG
(US8507533, 152)
Show SMILES Cc1cc(OC(C2CC(C)(C)C2)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-n1cc(cn1)C(F)(F)F
Show InChI InChI=1/C29H32F3N3O4/c1-17-11-23(12-18(2)25(17)35-16-22(15-34-35)29(30,31)32)39-26(21-13-28(3,4)14-21)19-5-7-20(8-6-19)27(38)33-10-9-24(36)37/h5-8,11-12,15-16,21,26H,9-10,13-14H2,1-4H3,(H,33,38)(H,36,37)
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35.2n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100831
PNG
(US8507533, 144)
Show SMILES CCCC(Oc1cc(C)c(c(C)c1)-n1cc(cn1)C1CC1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C28H33N3O4/c1-4-5-25(21-8-10-22(11-9-21)28(34)29-13-12-26(32)33)35-24-14-18(2)27(19(3)15-24)31-17-23(16-30-31)20-6-7-20/h8-11,14-17,20,25H,4-7,12-13H2,1-3H3,(H,29,34)(H,32,33)
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62.6n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433576
PNG
(CHEMBL2381849)
Show SMILES CCC[C@@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/s2
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64n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM100800
PNG
(US8507533, 108)
Show SMILES CCCC(Oc1ccc(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-12-11-23(32)33)35-20-9-10-21(16(2)13-20)31-15-19(14-30-31)25(26,27)28/h5-10,13-15,22H,3-4,11-12H2,1-2H3,(H,29,34)(H,32,33)
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200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100800
PNG
(US8507533, 108)
Show SMILES CCCC(Oc1ccc(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-12-11-23(32)33)35-20-9-10-21(16(2)13-20)31-15-19(14-30-31)25(26,27)28/h5-10,13-15,22H,3-4,11-12H2,1-2H3,(H,29,34)(H,32,33)
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203n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100857
PNG
(US8507533, 184)
Show SMILES CCCC(Oc1cc(F)c(c(F)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C24H22F5N3O4/c1-2-3-20(14-4-6-15(7-5-14)23(35)30-9-8-21(33)34)36-17-10-18(25)22(19(26)11-17)32-13-16(12-31-32)24(27,28)29/h4-7,10-13,20H,2-3,8-9H2,1H3,(H,30,35)(H,33,34)
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240n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon


(Homo sapiens (Human))
BDBM100843
PNG
(US8507533, 159)
Show SMILES CCCC(Oc1ccc(cc1C)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-12-11-23(32)33)35-21-10-9-20(13-16(21)2)31-15-19(14-30-31)25(26,27)28/h5-10,13-15,22H,3-4,11-12H2,1-2H3,(H,29,34)(H,32,33)
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315n/an/an/an/an/an/a7.4n/a



Pfizer Inc.

US Patent


Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors.


US Patent US8507533 (2013)


BindingDB Entry DOI: 10.7270/Q23R0RGH
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433579
PNG
(CHEMBL2381845)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(c(C)n1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C25H26F3N3O4/c1-3-4-22(17-5-7-18(8-6-17)24(34)29-14-13-23(32)33)35-20-11-9-19(10-12-20)31-15-21(16(2)30-31)25(26,27)28/h5-12,15,22H,3-4,13-14H2,1-2H3,(H,29,34)(H,32,33)
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1.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433586
PNG
(CHEMBL2381837)
Show SMILES CCC(Oc1ccc(cc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C23H22F3N3O4/c1-2-20(15-3-5-16(6-4-15)22(32)27-12-11-21(30)31)33-19-9-7-18(8-10-19)29-14-17(13-28-29)23(24,25)26/h3-10,13-14,20H,2,11-12H2,1H3,(H,27,32)(H,30,31)
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1.40E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433576
PNG
(CHEMBL2381849)
Show SMILES CCC[C@@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/s2
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1.60E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433584
PNG
(CHEMBL2381839)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(C)cn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C24H27N3O4/c1-3-4-22(18-5-7-19(8-6-18)24(30)25-14-13-23(28)29)31-21-11-9-20(10-12-21)27-16-17(2)15-26-27/h5-12,15-16,22H,3-4,13-14H2,1-2H3,(H,25,30)(H,28,29)
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1.90E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor (GLP-1)


(Homo sapiens (Human))
BDBM50433577
PNG
(CHEMBL2381848)
Show SMILES CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/s2
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3.16E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to GLP-1 receptor (unknown origin)


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433582
PNG
(CHEMBL2381842)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(cn1)C#N)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C24H24N4O4/c1-2-3-22(18-4-6-19(7-5-18)24(31)26-13-12-23(29)30)32-21-10-8-20(9-11-21)28-16-17(14-25)15-27-28/h4-11,15-16,22H,2-3,12-13H2,1H3,(H,26,31)(H,29,30)
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4.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433583
PNG
(CHEMBL2381841)
Show SMILES CCCC(Oc1ccc(cc1)-n1cccn1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C23H25N3O4/c1-2-4-21(30-20-11-9-19(10-12-20)26-16-3-14-25-26)17-5-7-18(8-6-17)23(29)24-15-13-22(27)28/h3,5-12,14,16,21H,2,4,13,15H2,1H3,(H,24,29)(H,27,28)
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4.10E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50433580
PNG
(CHEMBL2381844)
Show SMILES CCCC(Oc1ccc(cc1)-n1cc(cn1)C(=O)N(C)C)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1/C26H30N4O5/c1-4-5-23(18-6-8-19(9-7-18)25(33)27-15-14-24(31)32)35-22-12-10-21(11-13-22)30-17-20(16-28-30)26(34)29(2)3/h6-13,16-17,23H,4-5,14-15H2,1-3H3,(H,27,33)(H,31,32)
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UniProtKB/SwissProt

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UniChem

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PubMed
6.50E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin


Bioorg Med Chem Lett 23: 3051-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R
More data for this
Ligand-Target Pair