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7 similar compounds to monomer 12590

Compile data set for download or QSAR
Wt: 144.1
BDBM10450
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Wt: 159.1
BDBM32047
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Wt: 194.2
BDBM48247
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Wt: 195.2
BDBM66123
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Wt: 194.2
BDBM72700
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Wt: 195.2
BDBM83820
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Wt: 194.2
BDBM50419044
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 10450,32047,48247,66123,72700,83820,50419044   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50419044
PNG
(CHEMBL148204)
Show SMILES Nc1ccc2cc3ccccc3nc2c1
Show InChI InChI=1S/C13H10N2/c14-11-6-5-10-7-9-3-1-2-4-12(9)15-13(10)8-11/h1-8H,14H2
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PubMed
1.00E+3n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]granisetron from human 5-HT3AR expressed in HEK293 cells after 24 hrs by liquid scintillation counting


Bioorg Med Chem Lett 21: 5460-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.123
BindingDB Entry DOI: 10.7270/Q2ZC844K
More data for this
Ligand-Target Pair
Glutamate delta 2


(Xenopus)
BDBM72700
PNG
(9-acridinamine;hydrate;hydrochloride | 9-aminoacri...)
Show SMILES Nc1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
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>1.00E+4n/an/an/an/an/an/an/an/a



State University of New York

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 740-8 (2003)


Article DOI: 10.1124/jpet.102.045799
BindingDB Entry DOI: 10.7270/Q2N878C5
More data for this
Ligand-Target Pair
Trypanothione reductase


(Trypanosoma cruzi)
BDBM83820
PNG
(9-Amino-acridinium | 9-acridin-10-iumamine;chlorid...)
Show SMILES Nc1c2ccccc2[nH+]c2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)/p+1
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3.80E+4n/an/an/an/an/an/an/an/a



Heidelberg University

Curated by ChEMBL


Assay Description
The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots


J Med Chem 42: 5448-54 (2000)


Article DOI: 10.1021/jm990386s
BindingDB Entry DOI: 10.7270/Q2FJ2G0Q
More data for this
Ligand-Target Pair
Dual Specificity Protein Phosphatase 1


(Homo sapiens (Human))
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a>5.00E+4n/an/an/an/a7.022



University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay


Assay Description
The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2F769WQ
More data for this
Ligand-Target Pair
MKP-3


(Rattus norvegicus)
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay


Assay Description
The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2H70D6B
More data for this
Ligand-Target Pair
Bfl-1


(Mus musculus (Mouse))
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a 3.49E+3n/an/an/an/an/an/a



Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2K072NW
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (Human))
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



PCMD

Curated by PubChem BioAssay


Assay Description
Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q27D2SJC
More data for this
Ligand-Target Pair
matrix metalloproteinase 1


(Homo sapiens (Human))
BDBM48247
PNG
(1-acridinamine | Acridinamine | MLS000521341 | SMR...)
Show SMILES Nc1cccc2nc3ccccc3cc12
Show InChI InChI=1S/C13H10N2/c14-11-5-3-7-13-10(11)8-9-4-1-2-6-12(9)15-13/h1-8H,14H2
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n/an/an/an/a 2.19E+4n/an/an/an/a



Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2154FGT
More data for this
Ligand-Target Pair
MKP-3


(Rattus norvegicus)
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2W66J6B
More data for this
Ligand-Target Pair
Beta lactamase


(Pseudomonas aeruginosa)
BDBM66123
PNG
(9-aminopyrido[1,2-a]quinolinium | 9-benzo[c]quinol...)
Show SMILES Nc1ccc2ccc3cccc[n+]3c2c1
Show InChI InChI=1S/C13H10N2/c14-11-6-4-10-5-7-12-3-1-2-8-15(12)13(10)9-11/h1-9,14H/p+1
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n/an/a 9.33E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2S75DSB
More data for this
Ligand-Target Pair
beta-lactamase


(Salmonella enterica subsp. enterica serovar Choler...)
BDBM66123
PNG
(9-aminopyrido[1,2-a]quinolinium | 9-benzo[c]quinol...)
Show SMILES Nc1ccc2ccc3cccc[n+]3c2c1
Show InChI InChI=1S/C13H10N2/c14-11-6-4-10-5-7-12-3-1-2-8-15(12)13(10)9-11/h1-9,14H/p+1
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n/an/a 7.62E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2NG4P3G
More data for this
Ligand-Target Pair
metallo-beta-lactamase IMP-1


(Pseudomonas aeruginosa)
BDBM66123
PNG
(9-aminopyrido[1,2-a]quinolinium | 9-benzo[c]quinol...)
Show SMILES Nc1ccc2ccc3cccc[n+]3c2c1
Show InChI InChI=1S/C13H10N2/c14-11-6-4-10-5-7-12-3-1-2-8-15(12)13(10)9-11/h1-9,14H/p+1
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n/an/a 1.61E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2HT2MRM
More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM72700
PNG
(9-acridinamine;hydrate;hydrochloride | 9-aminoacri...)
Show SMILES Nc1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
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n/an/an/an/a 4.13E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2P55KXK
More data for this
Ligand-Target Pair
LANA


(Human herpesvirus 8)
BDBM66123
PNG
(9-aminopyrido[1,2-a]quinolinium | 9-benzo[c]quinol...)
Show SMILES Nc1ccc2ccc3cccc[n+]3c2c1
Show InChI InChI=1S/C13H10N2/c14-11-6-4-10-5-7-12-3-1-2-8-15(12)13(10)9-11/h1-9,14H/p+1
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n/an/an/an/a 6.54E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Primary Collaborators: Kenneth Kaye,Brigham & Womens,Boston MA,kkaye@rics.bwh.harvard.edu,617-525-4256 Chantal Beauchemin,Brigham & Womens,Boston MA,...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2HH6HHN
More data for this
Ligand-Target Pair
FXN frataxin


(Aspergillus niger)
BDBM48247
PNG
(1-acridinamine | Acridinamine | MLS000521341 | SMR...)
Show SMILES Nc1cccc2nc3ccccc3cc12
Show InChI InChI=1S/C13H10N2/c14-11-5-3-7-13-10(11)8-9-4-1-2-6-12(9)15-13/h1-8H,14H2
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n/an/an/an/a>6.63E+3n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TS...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2PK0DN5
More data for this
Ligand-Target Pair
FXN frataxin


(Aspergillus niger)
BDBM83820
PNG
(9-Amino-acridinium | 9-acridin-10-iumamine;chlorid...)
Show SMILES Nc1c2ccccc2[nH+]c2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)/p+1
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n/an/an/an/a>2.21E+3n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TS...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2PK0DN5
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM72700
PNG
(9-acridinamine;hydrate;hydrochloride | 9-aminoacri...)
Show SMILES Nc1c2ccccc2nc2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
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n/an/an/an/a 3.37E+3n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S4R
More data for this
Ligand-Target Pair
Probable global transcription activator SNF2L2


(Homo sapiens (Human))
BDBM83820
PNG
(9-Amino-acridinium | 9-acridin-10-iumamine;chlorid...)
Show SMILES Nc1c2ccccc2[nH+]c2ccccc12
Show InChI InChI=1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)/p+1
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n/an/an/an/a 3.38E+3n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2GF0S4R
More data for this
Ligand-Target Pair
Bfl-1


(Mus musculus (Mouse))
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a 3.49E+3n/an/an/an/a7.023



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2N014W6
More data for this
Ligand-Target Pair
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM32047
PNG
((5-amino-6-quinolyl)amine | MLS000036429 | SMR0000...)
Show SMILES Nc1ccc2ncccc2c1N
Show InChI InChI=1S/C9H9N3/c10-7-3-4-8-6(9(7)11)2-1-5-12-8/h1-5H,10-11H2
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n/an/a 3.38E+3n/an/an/an/a7.423



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2Q23XM6
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM10450
PNG
(4-Aminoquinoline 7 | quinolin-4-amine)
Show SMILES Nc1ccnc2ccccc12
Show InChI InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
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n/an/a 5.07E+4n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10450
PNG
(4-Aminoquinoline 7 | quinolin-4-amine)
Show SMILES Nc1ccnc2ccccc12
Show InChI InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)
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n/an/a 2.55E+5n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair