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3 similar compounds to monomer 107154

Wt: 446.4
BDBM107152
Wt: 496.8
BDBM107157
Wt: 494.8
BDBM107161

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 107152,107157,107161   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107157
PNG
(US8592426, 6)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H20ClF3N2O5/c1-33-19(30)18-15(3-2-4-16(18)24)13-5-7-14-12(9-13)6-8-17(14)28-20(31)22(10-34-11-22)29-21(32)23(25,26)27/h2-5,7,9,17H,6,8,10-11H2,1H3,(H,28,31)(H,29,32)/t17-/m0/s1
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US Patent
381n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107161
PNG
(US8592426, 10)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc2C(CCCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C24H22ClF3N2O4/c1-34-20(31)19-16(5-3-6-17(19)25)14-8-9-15-13(12-14)4-2-7-18(15)29-21(32)23(10-11-23)30-22(33)24(26,27)28/h3,5-6,8-9,12,18H,2,4,7,10-11H2,1H3,(H,29,32)(H,30,33)
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UniProtKB/SwissProt

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US Patent
522n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107152
PNG
(US8592426, 1)
Show SMILES COC(=O)c1ccccc1-c1ccc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H21F3N2O4/c1-32-19(29)17-5-3-2-4-15(17)13-6-8-16-14(12-13)7-9-18(16)27-20(30)22(10-11-22)28-21(31)23(24,25)26/h2-6,8,12,18H,7,9-11H2,1H3,(H,27,30)(H,28,31)
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US Patent
2.17E+3n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107161
PNG
(US8592426, 10)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc2C(CCCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C24H22ClF3N2O4/c1-34-20(31)19-16(5-3-6-17(19)25)14-8-9-15-13(12-14)4-2-7-18(15)29-21(32)23(10-11-23)30-22(33)24(26,27)28/h3,5-6,8-9,12,18H,2,4,7,10-11H2,1H3,(H,29,32)(H,30,33)
Reactome pathway
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UniProtKB/SwissProt

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US Patent
n/an/a 118n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107152
PNG
(US8592426, 1)
Show SMILES COC(=O)c1ccccc1-c1ccc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H21F3N2O4/c1-32-19(29)17-5-3-2-4-15(17)13-6-8-16-14(12-13)7-9-18(16)27-20(30)22(10-11-22)28-21(31)23(24,25)26/h2-6,8,12,18H,7,9-11H2,1H3,(H,27,30)(H,28,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 2.25E+3n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107157
PNG
(US8592426, 6)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H20ClF3N2O5/c1-33-19(30)18-15(3-2-4-16(18)24)13-5-7-14-12(9-13)6-8-17(14)28-20(31)22(10-34-11-22)29-21(32)23(25,26)27/h2-5,7,9,17H,6,8,10-11H2,1H3,(H,28,31)(H,29,32)/t17-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
US Patent
n/an/a 455n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair