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9 similar compounds to monomer 107202

Wt: 567.9
BDBM107203
Wt: 538.8
BDBM107158
Wt: 521.9
BDBM107179
Wt: 551.9
BDBM107181
Wt: 569.9
BDBM107186
Wt: 548.9
BDBM107200
Wt: 537.9
BDBM107201
Wt: 557.9
BDBM140551

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 107203,107158,107179,107181,107186,107200,107201,140551   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM140551
PNG
(US8912221, 24)
Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1cc(C)no1)c1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1/C26H22ClF2N5O5/c1-12-6-21(39-33-12)24(35)32-26(10-37-11-26)25(36)30-13(2)17-5-4-15(7-19(17)28)18-8-16(27)9-20(29)22(18)23-31-14(3)38-34-23/h4-9,13H,10-11H2,1-3H3,(H,30,36)(H,32,35)/t13-/s2
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1.20n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...


US Patent US8912221 (2014)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107203
PNG
(US8592426, 53)
Show SMILES COc1cc(on1)C(=O)NC1(COC1)C(=O)N[C@H]1CCc2cc(ccc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN5O6/c1-13-30-24(34-39-13)23-18(8-16(28)9-19(23)29)15-3-5-17-14(7-15)4-6-20(17)31-26(36)27(11-38-12-27)32-25(35)21-10-22(37-2)33-40-21/h3,5,7-10,20H,4,6,11-12H2,1-2H3,(H,31,36)(H,32,35)/t20-/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107181
PNG
(US8592426, 30)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)N[C@H]1CCc2cc(ccc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN5O5/c1-13-30-24(34-38-13)23-18(10-16(28)11-19(23)29)15-3-5-17-14(9-15)4-6-20(17)31-26(36)27(7-8-27)32-25(35)21-12-22(37-2)33-39-21/h3,5,9-12,20H,4,6-8H2,1-2H3,(H,31,36)(H,32,35)/t20-/m0/s1
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3.90n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107179
PNG
(US8592426, 28)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O4/c1-13-30-23(33-36-13)22-18(11-16(27)12-19(22)28)15-2-4-17-14(10-15)3-5-20(17)31-25(35)26(7-8-26)32-24(34)21-6-9-29-37-21/h2,4,6,9-12,20H,3,5,7-8H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107200
PNG
(US8592426, 50)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)c1cncnc1
Show InChI InChI=1S/C27H22ClFN6O4/c1-14-32-24(35-39-14)23-20(7-18(28)8-21(23)29)16-2-4-19-15(6-16)3-5-22(19)33-26(37)27(11-38-12-27)34-25(36)17-9-30-13-31-10-17/h2,4,6-10,13,22H,3,5,11-12H2,1H3,(H,33,37)(H,34,36)/t22-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107201
PNG
(US8592426, 51)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O5/c1-13-30-23(33-37-13)22-18(9-16(27)10-19(22)28)15-2-4-17-14(8-15)3-5-20(17)31-25(35)26(11-36-12-26)32-24(34)21-6-7-29-38-21/h2,4,6-10,20H,3,5,11-12H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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11.8n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107186
PNG
(US8592426, 35)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cc(F)c12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H22ClF2N5O5/c1-12-31-24(35-39-12)23-16(9-15(28)10-18(23)30)14-7-13-3-4-19(22(13)17(29)8-14)32-26(37)27(5-6-27)33-25(36)20-11-21(38-2)34-40-20/h7-11,19H,3-6H2,1-2H3,(H,32,37)(H,33,36)
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17.1n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107158
PNG
(US8592426, 7)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C24H19ClF4N4O4/c1-11-30-20(33-37-11)19-16(7-14(25)8-17(19)26)13-2-4-15-12(6-13)3-5-18(15)31-21(34)23(9-36-10-23)32-22(35)24(27,28)29/h2,4,6-8,18H,3,5,9-10H2,1H3,(H,31,34)(H,32,35)/t18-/m0/s1
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37.4n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107203
PNG
(US8592426, 53)
Show SMILES COc1cc(on1)C(=O)NC1(COC1)C(=O)N[C@H]1CCc2cc(ccc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN5O6/c1-13-30-24(34-39-13)23-18(8-16(28)9-19(23)29)15-3-5-17-14(7-15)4-6-20(17)31-26(36)27(11-38-12-27)32-25(35)21-10-22(37-2)33-40-21/h3,5,7-10,20H,4,6,11-12H2,1-2H3,(H,31,36)(H,32,35)/t20-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107201
PNG
(US8592426, 51)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O5/c1-13-30-23(33-37-13)22-18(9-16(27)10-19(22)28)15-2-4-17-14(8-15)3-5-20(17)31-25(35)26(11-36-12-26)32-24(34)21-6-7-29-38-21/h2,4,6-10,20H,3,5,11-12H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107200
PNG
(US8592426, 50)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)c1cncnc1
Show InChI InChI=1S/C27H22ClFN6O4/c1-14-32-24(35-39-14)23-20(7-18(28)8-21(23)29)16-2-4-19-15(6-16)3-5-22(19)33-26(37)27(11-38-12-27)34-25(36)17-9-30-13-31-10-17/h2,4,6-10,13,22H,3,5,11-12H2,1H3,(H,33,37)(H,34,36)/t22-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107186
PNG
(US8592426, 35)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cc(F)c12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H22ClF2N5O5/c1-12-31-24(35-39-12)23-16(9-15(28)10-18(23)30)14-7-13-3-4-19(22(13)17(29)8-14)32-26(37)27(5-6-27)33-25(36)20-11-21(38-2)34-40-20/h7-11,19H,3-6H2,1-2H3,(H,32,37)(H,33,36)
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n/an/a 0.5n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107181
PNG
(US8592426, 30)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)N[C@H]1CCc2cc(ccc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN5O5/c1-13-30-24(34-38-13)23-18(10-16(28)11-19(23)29)15-3-5-17-14(9-15)4-6-20(17)31-26(36)27(7-8-27)32-25(35)21-12-22(37-2)33-39-21/h3,5,9-12,20H,4,6-8H2,1-2H3,(H,31,36)(H,32,35)/t20-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107179
PNG
(US8592426, 28)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O4/c1-13-30-23(33-36-13)22-18(11-16(27)12-19(22)28)15-2-4-17-14(10-15)3-5-20(17)31-25(35)26(7-8-26)32-24(34)21-6-9-29-37-21/h2,4,6,9-12,20H,3,5,7-8H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107158
PNG
(US8592426, 7)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(COC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C24H19ClF4N4O4/c1-11-30-20(33-37-11)19-16(7-14(25)8-17(19)26)13-2-4-15-12(6-13)3-5-18(15)31-21(34)23(9-36-10-23)32-22(35)24(27,28)29/h2,4,6-8,18H,3,5,9-10H2,1H3,(H,31,34)(H,32,35)/t18-/m0/s1
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n/an/a 28.6n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair