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9 similar compounds to monomer 107194

Wt: 533.9
BDBM107190
Wt: 523.8
BDBM107163
Wt: 521.9
BDBM107179
Wt: 527.9
BDBM107187
Wt: 427.8
BDBM107188
Wt: 552.9
BDBM107189
Wt: 563.9
BDBM107193
Wt: 544.8
BDBM140530
Wt: 558.9
BDBM140531

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 107190,107163,107179,107187,107188,107189,107193,140530,140531   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM140530
PNG
(US8912221, 3)
Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1ccno1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1/C24H19ClF2N6O5/c1-11(30-23(35)24(9-36-10-24)32-22(34)18-3-4-29-38-18)20-17(27)5-13(8-28-20)15-6-14(25)7-16(26)19(15)21-31-12(2)37-33-21/h3-8,11H,9-10H2,1-2H3,(H,30,35)(H,32,34)/t11-/s2
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2.40n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...


US Patent US8912221 (2014)

More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM140531
PNG
(US8912221, 4)
Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1cc(C)no1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1/C25H21ClF2N6O5/c1-11-4-19(39-33-11)23(35)32-25(9-37-10-25)24(36)30-12(2)21-18(28)5-14(8-29-21)16-6-15(26)7-17(27)20(16)22-31-13(3)38-34-22/h4-8,12H,9-10H2,1-3H3,(H,30,36)(H,32,35)/t12-/s2
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2.5n/an/an/an/an/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...


US Patent US8912221 (2014)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107189
PNG
(US8592426, 38)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C26H22ClFN6O5/c1-12-30-23(34-38-12)21-16(8-15(27)9-17(21)28)14-7-13-3-4-18(22(13)29-11-14)31-25(36)26(5-6-26)32-24(35)19-10-20(37-2)33-39-19/h7-11,18H,3-6H2,1-2H3,(H,31,36)(H,32,35)
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3n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107193
PNG
(US8592426, 42)
Show SMILES COc1ncc(cn1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN7O4/c1-13-33-23(36-40-13)21-18(8-17(28)9-19(21)29)15-7-14-3-4-20(22(14)30-10-15)34-25(38)27(5-6-27)35-24(37)16-11-31-26(39-2)32-12-16/h7-12,20H,3-6H2,1-2H3,(H,34,38)(H,35,37)
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4n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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4n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107179
PNG
(US8592426, 28)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O4/c1-13-30-23(33-36-13)22-18(11-16(27)12-19(22)28)15-2-4-17-14(10-15)3-5-20(17)31-25(35)26(7-8-26)32-24(34)21-6-9-29-37-21/h2,4,6,9-12,20H,3,5,7-8H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107163
PNG
(US8592426, 12)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H18ClF4N5O3/c1-10-30-19(33-36-10)17-14(7-13(24)8-15(17)25)12-6-11-2-3-16(18(11)29-9-12)31-20(34)22(4-5-22)32-21(35)23(26,27)28/h6-9,16H,2-5H2,1H3,(H,31,34)(H,32,35)
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4.40n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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7.5n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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130n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107187
PNG
(US8592426, 36)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C26H27ClFN5O4/c1-13-30-22(33-37-13)20-17(10-16(27)11-18(20)28)15-9-14-5-6-19(21(14)29-12-15)31-23(34)26(7-8-26)32-24(35)36-25(2,3)4/h9-12,19H,5-8H2,1-4H3,(H,31,34)(H,32,35)
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361n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107188
PNG
(US8592426, 37)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(N)CC1
Show InChI InChI=1S/C21H19ClFN5O2/c1-10-26-19(28-30-10)17-14(7-13(22)8-15(17)23)12-6-11-2-3-16(18(11)25-9-12)27-20(29)21(24)4-5-21/h6-9,16H,2-5,24H2,1H3,(H,27,29)
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591n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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n/an/a 35.2n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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n/an/a 0.200n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107193
PNG
(US8592426, 42)
Show SMILES COc1ncc(cn1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C27H23ClFN7O4/c1-13-33-23(36-40-13)21-18(8-17(28)9-19(21)29)15-7-14-3-4-20(22(14)30-10-15)34-25(38)27(5-6-27)35-24(37)16-11-31-26(39-2)32-12-16/h7-12,20H,3-6H2,1-2H3,(H,34,38)(H,35,37)
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n/an/a 0.200n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107190
PNG
(US8592426, 116 | US8592426, 117 | US8592426, 39/40...)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccnnc1
Show InChI InChI=1S/C26H21ClFN7O3/c1-13-32-23(35-38-13)21-18(9-17(27)10-19(21)28)16-8-14-2-3-20(22(14)29-11-16)33-25(37)26(5-6-26)34-24(36)15-4-7-30-31-12-15/h4,7-12,20H,2-3,5-6H2,1H3,(H,33,37)(H,34,36)
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n/an/a 0.600n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107189
PNG
(US8592426, 38)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C26H22ClFN6O5/c1-12-30-23(34-38-12)21-16(8-15(27)9-17(21)28)14-7-13-3-4-18(22(13)29-11-14)31-25(36)26(5-6-26)32-24(35)19-10-20(37-2)33-39-19/h7-11,18H,3-6H2,1-2H3,(H,31,36)(H,32,35)
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n/an/a 0.200n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107187
PNG
(US8592426, 36)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C26H27ClFN5O4/c1-13-30-22(33-37-13)20-17(10-16(27)11-18(20)28)15-9-14-5-6-19(21(14)29-12-15)31-23(34)26(7-8-26)32-24(35)36-25(2,3)4/h9-12,19H,5-8H2,1-4H3,(H,31,34)(H,32,35)
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n/an/a 3.60n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107179
PNG
(US8592426, 28)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1ccc2[C@H](CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C26H21ClFN5O4/c1-13-30-23(33-36-13)22-18(11-16(27)12-19(22)28)15-2-4-17-14(10-15)3-5-20(17)31-25(35)26(7-8-26)32-24(34)21-6-9-29-37-21/h2,4,6,9-12,20H,3,5,7-8H2,1H3,(H,31,35)(H,32,34)/t20-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107163
PNG
(US8592426, 12)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C23H18ClF4N5O3/c1-10-30-19(33-36-10)17-14(7-13(24)8-15(17)25)12-6-11-2-3-16(18(11)29-9-12)31-20(34)22(4-5-22)32-21(35)23(26,27)28/h6-9,16H,2-5H2,1H3,(H,31,34)(H,32,35)
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n/an/a 0.5n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107188
PNG
(US8592426, 37)
Show SMILES Cc1nc(no1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(N)CC1
Show InChI InChI=1S/C21H19ClFN5O2/c1-10-26-19(28-30-10)17-14(7-13(22)8-15(17)23)12-6-11-2-3-16(18(11)25-9-12)27-20(29)21(24)4-5-21/h6-9,16H,2-5,24H2,1H3,(H,27,29)
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KEGG

UniProtKB/SwissProt

antibodypedia
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UniChem

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US Patent
n/an/a 301n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair