BindingDB logo
myBDB logout

6 similar compounds to monomer 107206

Wt: 527.9
BDBM107204
Wt: 427.8
BDBM107205
Wt: 522.9
BDBM107207
Wt: 536.9
BDBM107208
Wt: 552.9
BDBM107209
Wt: 523.8
BDBM107164

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 107204,107205,107207,107208,107209,107164   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107209
PNG
(US8592426, 59)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C25H22ClFN8O4/c1-35-32-22(31-34-35)20-15(8-14(26)9-16(20)27)13-7-12-3-4-17(21(12)28-11-13)29-24(37)25(5-6-25)30-23(36)18-10-19(38-2)33-39-18/h7-11,17H,3-6H2,1-2H3,(H,29,37)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
3.5n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107207
PNG
(US8592426, 57)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C24H20ClFN8O3/c1-34-32-21(31-33-34)19-15(9-14(25)10-16(19)26)13-8-12-2-3-17(20(12)27-11-13)29-23(36)24(5-6-24)30-22(35)18-4-7-28-37-18/h4,7-11,17H,2-3,5-6H2,1H3,(H,29,36)(H,30,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
5.80n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107208
PNG
(US8592426, 58)
Show SMILES Cc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C25H22ClFN8O3/c1-12-7-19(38-33-12)23(36)30-25(5-6-25)24(37)29-18-4-3-13-8-14(11-28-21(13)18)16-9-15(26)10-17(27)20(16)22-31-34-35(2)32-22/h7-11,18H,3-6H2,1-2H3,(H,29,37)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
6.30n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107164
PNG
(US8592426, 13)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N7O2/c1-34-32-18(31-33-34)16-13(7-12(23)8-14(16)24)11-6-10-2-3-15(17(10)28-9-11)29-19(35)21(4-5-21)30-20(36)22(25,26)27/h6-9,15H,2-5H2,1H3,(H,29,35)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
9.5n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107204
PNG
(US8592426, 54)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C25H27ClFN7O3/c1-24(2,3)37-23(36)30-25(7-8-25)22(35)29-18-6-5-13-9-14(12-28-20(13)18)16-10-15(26)11-17(27)19(16)21-31-33-34(4)32-21/h9-12,18H,5-8H2,1-4H3,(H,29,35)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
63.2n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107205
PNG
(US8592426, 55)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(N)CC1
Show InChI InChI=1S/C20H19ClFN7O/c1-29-27-18(26-28-29)16-13(7-12(21)8-14(16)22)11-6-10-2-3-15(17(10)24-9-11)25-19(30)20(23)4-5-20/h6-9,15H,2-5,23H2,1H3,(H,25,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
211n/an/an/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Binding assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107208
PNG
(US8592426, 58)
Show SMILES Cc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C25H22ClFN8O3/c1-12-7-19(38-33-12)23(36)30-25(5-6-25)24(37)29-18-4-3-13-8-14(11-28-21(13)18)16-9-15(26)10-17(27)20(16)22-31-34-35(2)32-22/h7-11,18H,3-6H2,1-2H3,(H,29,37)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107207
PNG
(US8592426, 57)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)c1ccno1
Show InChI InChI=1S/C24H20ClFN8O3/c1-34-32-21(31-33-34)19-15(9-14(25)10-16(19)26)13-8-12-2-3-17(20(12)27-11-13)29-23(36)24(5-6-24)30-22(35)18-4-7-28-37-18/h4,7-11,17H,2-3,5-6H2,1H3,(H,29,36)(H,30,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107205
PNG
(US8592426, 55)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(N)CC1
Show InChI InChI=1S/C20H19ClFN7O/c1-29-27-18(26-28-29)16-13(7-12(21)8-14(16)22)11-6-10-2-3-15(17(10)24-9-11)25-19(30)20(23)4-5-20/h6-9,15H,2-5,23H2,1H3,(H,25,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 61.1n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107204
PNG
(US8592426, 54)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C25H27ClFN7O3/c1-24(2,3)37-23(36)30-25(7-8-25)22(35)29-18-6-5-13-9-14(12-28-20(13)18)16-10-15(26)11-17(27)19(16)21-31-33-34(4)32-21/h9-12,18H,5-8H2,1-4H3,(H,29,35)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 5.80n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107209
PNG
(US8592426, 59)
Show SMILES COc1cc(on1)C(=O)NC1(CC1)C(=O)NC1CCc2cc(cnc12)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C25H22ClFN8O4/c1-35-32-22(31-34-35)20-15(8-14(26)9-16(20)27)13-7-12-3-4-17(21(12)28-11-13)29-24(37)25(5-6-25)30-23(36)18-10-19(38-2)33-39-18/h7-11,17H,3-6H2,1-2H3,(H,29,37)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair
Bradykinin-1 Receptor


(Homo sapiens (Human))
BDBM107164
PNG
(US8592426, 13)
Show SMILES Cn1nnc(n1)-c1c(F)cc(Cl)cc1-c1cnc2C(CCc2c1)NC(=O)C1(CC1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N7O2/c1-34-32-18(31-33-34)16-13(7-12(23)8-14(16)24)11-6-10-2-3-15(17(10)28-9-11)29-19(35)21(4-5-21)30-20(36)22(25,26)27/h6-9,15H,2-5H2,1H3,(H,29,35)(H,30,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Hoffmann—La Roche Inc.

US Patent


Assay Description
Calcium mobilization assay using Bradykinin-1 receptor.


US Patent US8592426 (2013)

More data for this
Ligand-Target Pair