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25 similar compounds to monomer 108282

Compile data set for download or QSAR
Wt: 510.7
BDBM108279
Wt: 396.5
BDBM108283
Wt: 515.6
BDBM108285
Wt: 452.6
BDBM108291
Wt: 506.7
BDBM108292
Wt: 450.6
BDBM108293
Wt: 464.5
BDBM108307
Wt: 560.6
BDBM108314
Wt: 396.5
BDBM108265
Wt: 396.5
BDBM108266
Wt: 396.5
BDBM108267
Wt: 396.5
BDBM108268
Wt: 478.7
BDBM108269
Wt: 478.7
BDBM108270
Wt: 478.7
BDBM108271
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 108279,108283,108285,108291,108292,108293,108307,108314,108265,108266,108267,108268,108269,108270,108271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108283
PNG
(US8604046, 63)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCCC2(CCNCC2)C1=O
Show InChI InChI=1S/C24H36N4O/c1-19-4-2-15-27(19)22-9-17-26(18-22)20-5-7-21(8-6-20)28-16-3-10-24(23(28)29)11-13-25-14-12-24/h5-8,19,22,25H,2-4,9-18H2,1H3/t19-,22-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108293
PNG
(US8604046, 73)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCCC2(CCN(CC3CC3)CC2)C1=O
Show InChI InChI=1S/C28H42N4O/c1-22-4-2-15-31(22)26-11-17-30(21-26)24-7-9-25(10-8-24)32-16-3-12-28(27(32)33)13-18-29(19-14-28)20-23-5-6-23/h7-10,22-23,26H,2-6,11-21H2,1H3/t22-,26-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108292
PNG
(US8604046, 72)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC4CCCCC4)CC3)C2=O)c(C)c1
Show InChI InChI=1S/C32H50N4O/c1-25-22-28(34-19-13-29(24-34)35-17-6-8-26(35)2)11-12-30(25)36-18-7-14-32(31(36)37)15-20-33(21-16-32)23-27-9-4-3-5-10-27/h11-12,22,26-27,29H,3-10,13-21,23-24H2,1-2H3/t26-,29-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108291
PNG
(US8604046, 71)
Show SMILES CC(C)N1CCC2(CCCN(C2=O)c2ccc(cc2C)N2CC[C@@H](C2)N2CCC[C@@H]2C)CC1
Show InChI InChI=1S/C28H44N4O/c1-21(2)29-17-12-28(13-18-29)11-6-15-32(27(28)33)26-9-8-24(19-22(26)3)30-16-10-25(20-30)31-14-5-7-23(31)4/h8-9,19,21,23,25H,5-7,10-18,20H2,1-4H3/t23-,25-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108268
PNG
(US8604046, 48)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)c1
Show InChI InChI=1S/C24H36N4O/c1-18-16-20(26-14-7-21(17-26)27-13-3-4-19(27)2)5-6-22(18)28-15-10-24(23(28)29)8-11-25-12-9-24/h5-6,16,19,21,25H,3-4,7-15,17H2,1-2H3/t19-,21+/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108307
PNG
(US8604046, 87)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H35F3N4O/c1-18-4-2-3-13-31(18)20-7-14-30(17-20)19-5-6-22(21(16-19)25(26,27)28)32-15-10-24(23(32)33)8-11-29-12-9-24/h5-6,16,18,20,29H,2-4,7-15,17H2,1H3/t18-,20-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108271
PNG
(US8604046, 51)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCCC4)CC3)C2=O)c(C)c1
Show InChI InChI=1S/C30H46N4O/c1-23-20-26(32-16-11-27(22-32)33-15-5-6-24(33)2)9-10-28(23)34-19-14-30(29(34)35)12-17-31(18-13-30)21-25-7-3-4-8-25/h9-10,20,24-25,27H,3-8,11-19,21-22H2,1-2H3/t24-,27+/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108267
PNG
(US8604046, 47)
Show SMILES C[C@@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)c1
Show InChI InChI=1S/C24H36N4O/c1-18-16-20(26-14-7-21(17-26)27-13-3-4-19(27)2)5-6-22(18)28-15-10-24(23(28)29)8-11-25-12-9-24/h5-6,16,19,21,25H,3-4,7-15,17H2,1-2H3/t19-,21+/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108314
PNG
(US8604046, 94)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)C3CCCC3)C2=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H43F3N4O2/c1-22-6-4-5-15-37(22)25-11-16-36(21-25)24-9-10-27(26(20-24)31(32,33)34)38-19-14-30(29(38)40)12-17-35(18-13-30)28(39)23-7-2-3-8-23/h9-10,20,22-23,25H,2-8,11-19,21H2,1H3/t22-,25-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108285
PNG
(US8604046, 65)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)c3ccncc3)C2=O)c(C)c1
Show InChI InChI=1S/C31H41N5O2/c1-23-21-26(34-18-10-27(22-34)35-16-3-5-24(35)2)6-7-28(23)36-17-4-11-31(30(36)38)12-19-33(20-13-31)29(37)25-8-14-32-15-9-25/h6-9,14-15,21,24,27H,3-5,10-13,16-20,22H2,1-2H3/t24-,27-/m0/s1
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4n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108279
PNG
(US8604046, 59)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(C)c1
Show InChI InChI=1S/C30H46N4O3/c1-22-20-24(32-17-11-25(21-32)33-15-6-8-23(33)2)9-10-26(22)34-16-7-12-30(27(34)35)13-18-31(19-14-30)28(36)37-29(3,4)5/h9-10,20,23,25H,6-8,11-19,21H2,1-5H3/t23-,25-/m0/s1
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6.80n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108265
PNG
(US8604046, 45)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)c1
Show InChI InChI=1S/C24H36N4O/c1-18-16-20(26-14-7-21(17-26)27-13-3-4-19(27)2)5-6-22(18)28-15-10-24(23(28)29)8-11-25-12-9-24/h5-6,16,19,21,25H,3-4,7-15,17H2,1-2H3/t19-,21-/m0/s1
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11n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108269
PNG
(US8604046, 49)
Show SMILES C[C@@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCCC4)CC3)C2=O)c(C)c1
Show InChI InChI=1S/C30H46N4O/c1-23-20-26(32-16-11-27(22-32)33-15-5-6-24(33)2)9-10-28(23)34-19-14-30(29(34)35)12-17-31(18-13-30)21-25-7-3-4-8-25/h9-10,20,24-25,27H,3-8,11-19,21-22H2,1-2H3/t24-,27+/m1/s1
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12n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108266
PNG
(US8604046, 46)
Show SMILES C[C@@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)c1
Show InChI InChI=1S/C24H36N4O/c1-18-16-20(26-14-7-21(17-26)27-13-3-4-19(27)2)5-6-22(18)28-15-10-24(23(28)29)8-11-25-12-9-24/h5-6,16,19,21,25H,3-4,7-15,17H2,1-2H3/t19-,21-/m1/s1
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15n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108270
PNG
(US8604046, 50)
Show SMILES C[C@@H]1CCCN1[C@@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCCC4)CC3)C2=O)c(C)c1
Show InChI InChI=1S/C30H46N4O/c1-23-20-26(32-16-11-27(22-32)33-15-5-6-24(33)2)9-10-28(23)34-19-14-30(29(34)35)12-17-31(18-13-30)21-25-7-3-4-8-25/h9-10,20,24-25,27H,3-8,11-19,21-22H2,1-2H3/t24-,27-/m1/s1
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22n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair