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7 similar compounds to monomer 108281

Compile data set for download or QSAR
Wt: 496.6
BDBM108280
Wt: 414.5
BDBM108284
Wt: 524.7
BDBM108289
Wt: 526.6
BDBM108290
Wt: 514.6
BDBM108299
Wt: 514.6
BDBM108302
Wt: 414.5
BDBM108308

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 108280,108284,108289,108290,108299,108302,108308   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108284
PNG
(US8604046, 64)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C24H35FN4O/c1-18-4-2-13-28(18)20-7-15-27(17-20)19-5-6-22(21(25)16-19)29-14-3-8-24(23(29)30)9-11-26-12-10-24/h5-6,16,18,20,26H,2-4,7-15,17H2,1H3/t18-,20-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.0600n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108299
PNG
(US8604046, 79)
Show SMILES C[C@H]1CCCN1C1CCN(CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1S/C29H43FN4O3/c1-21-6-5-14-33(21)22-9-15-31(16-10-22)23-7-8-25(24(30)20-23)34-19-13-29(26(34)35)11-17-32(18-12-29)27(36)37-28(2,3)4/h7-8,20-22H,5-6,9-19H2,1-4H3/t21-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.300n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108290
PNG
(US8604046, 70)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)C3CCOCC3)C2=O)c(F)c1
Show InChI InChI=1S/C30H43FN4O3/c1-22-4-2-13-34(22)25-7-15-33(21-25)24-5-6-27(26(31)20-24)35-14-3-10-30(29(35)37)11-16-32(17-12-30)28(36)23-8-18-38-19-9-23/h5-6,20,22-23,25H,2-4,7-19,21H2,1H3/t22-,25-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108308
PNG
(US8604046, 88)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C24H35FN4O/c1-18-4-2-3-13-28(18)20-7-14-27(17-20)19-5-6-22(21(25)16-19)29-15-10-24(23(29)30)8-11-26-12-9-24/h5-6,16,18,20,26H,2-4,7-15,17H2,1H3/t18-,20-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108289
PNG
(US8604046, 69)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)C3CCCCC3)C2=O)c(F)c1
Show InChI InChI=1S/C31H45FN4O2/c1-23-7-5-16-35(23)26-12-18-34(22-26)25-10-11-28(27(32)21-25)36-17-6-13-31(30(36)38)14-19-33(20-15-31)29(37)24-8-3-2-4-9-24/h10-11,21,23-24,26H,2-9,12-20,22H2,1H3/t23-,26-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.700n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108302
PNG
(US8604046, 82)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1S/C29H43FN4O3/c1-21-7-5-6-14-33(21)23-10-15-32(20-23)22-8-9-25(24(30)19-22)34-18-13-29(26(34)35)11-16-31(17-12-29)27(36)37-28(2,3)4/h8-9,19,21,23H,5-7,10-18,20H2,1-4H3/t21-,23-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
4.30n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108280
PNG
(US8604046, 60)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C29H44N4O3/c1-22-7-5-16-32(22)25-12-18-31(21-25)23-8-10-24(11-9-23)33-17-6-13-29(26(33)34)14-19-30(20-15-29)27(35)36-28(2,3)4/h8-11,22,25H,5-7,12-21H2,1-4H3/t22-,25-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
7.30n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair