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11 similar compounds to monomer 108284

Compile data set for download or QSAR
Wt: 500.6
BDBM108281
Wt: 524.7
BDBM108289
Wt: 526.6
BDBM108290
Wt: 504.6
BDBM108295
Wt: 514.6
BDBM108302
Wt: 414.5
BDBM108305
Wt: 414.5
BDBM108308
Wt: 524.7
BDBM108311
Wt: 468.6
BDBM108315
Wt: 496.7
BDBM108316
Wt: 512.7
BDBM108318

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 108281,108289,108290,108295,108302,108305,108308,108311,108315,108316,108318   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108281
PNG
(US8604046, 61)
Show SMILES CC(C)(C)OC(=O)N1CCC2(CCCN(C2=O)c2ccc(cc2F)N2CC[C@@H](C2)N2CCCC2)CC1
Show InChI InChI=1S/C28H41FN4O3/c1-27(2,3)36-26(35)31-17-11-28(12-18-31)10-6-15-33(25(28)34)24-8-7-21(19-23(24)29)32-16-9-22(20-32)30-13-4-5-14-30/h7-8,19,22H,4-6,9-18,20H2,1-3H3/t22-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.0300n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108315
PNG
(US8604046, 95)
Show SMILES C[C@H]1CCCN1C1CCN(CC1)c1ccc(N2CCC3(CCN(CC4CC4)CC3)C2=O)c(F)c1
Show InChI InChI=1S/C28H41FN4O/c1-21-3-2-13-32(21)23-8-14-31(15-9-23)24-6-7-26(25(29)19-24)33-18-12-28(27(33)34)10-16-30(17-11-28)20-22-4-5-22/h6-7,19,21-23H,2-5,8-18,20H2,1H3/t21-/m0/s1
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US Patent
0.0400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108295
PNG
(US8604046, 75)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(Cc4ccccc4)CC3)C2=O)c(F)c1
Show InChI InChI=1S/C31H41FN4O/c1-24-7-5-16-35(24)27-12-18-34(23-27)26-10-11-29(28(32)21-26)36-17-6-13-31(30(36)37)14-19-33(20-15-31)22-25-8-3-2-4-9-25/h2-4,8-11,21,24,27H,5-7,12-20,22-23H2,1H3/t24-,27-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.0600n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108305
PNG
(US8604046, 85)
Show SMILES C[C@H]1CCCN1C1CCN(CC1)c1ccc(N2CCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C24H35FN4O/c1-18-3-2-13-28(18)19-6-14-27(15-7-19)20-4-5-22(21(25)17-20)29-16-10-24(23(29)30)8-11-26-12-9-24/h4-5,17-19,26H,2-3,6-16H2,1H3/t18-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.100n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108316
PNG
(US8604046, 96)
Show SMILES C[C@H]1CCCN1C1CCN(CC1)c1ccc(N2CCC3(CCN(CC4CCCC4)CC3)C2=O)c(F)c1
Show InChI InChI=1S/C30H45FN4O/c1-23-5-4-15-34(23)25-10-16-33(17-11-25)26-8-9-28(27(31)21-26)35-20-14-30(29(35)36)12-18-32(19-13-30)22-24-6-2-3-7-24/h8-9,21,23-25H,2-7,10-20,22H2,1H3/t23-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.100n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108311
PNG
(US8604046, 91)
Show SMILES C[C@H]1CCCN1C1CCN(CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)C3CCCCC3)C2=O)c(F)c1
Show InChI InChI=1S/C31H45FN4O2/c1-23-6-5-16-35(23)25-11-17-33(18-12-25)26-9-10-28(27(32)22-26)36-21-15-31(30(36)38)13-19-34(20-14-31)29(37)24-7-3-2-4-8-24/h9-10,22-25H,2-8,11-21H2,1H3/t23-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.200n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108290
PNG
(US8604046, 70)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)C3CCOCC3)C2=O)c(F)c1
Show InChI InChI=1S/C30H43FN4O3/c1-22-4-2-13-34(22)25-7-15-33(21-25)24-5-6-27(26(31)20-24)35-14-3-10-30(29(35)37)11-16-32(17-12-30)28(36)23-8-18-38-19-9-23/h5-6,20,22-23,25H,2-4,7-19,21H2,1H3/t22-,25-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108308
PNG
(US8604046, 88)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(F)c1
Show InChI InChI=1S/C24H35FN4O/c1-18-4-2-3-13-28(18)20-7-14-27(17-20)19-5-6-22(21(25)16-19)29-15-10-24(23(29)30)8-11-26-12-9-24/h5-6,16,18,20,26H,2-4,7-15,17H2,1H3/t18-,20-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108289
PNG
(US8604046, 69)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC3)C(=O)C3CCCCC3)C2=O)c(F)c1
Show InChI InChI=1S/C31H45FN4O2/c1-23-7-5-16-35(23)26-12-18-34(22-26)25-10-11-28(27(32)21-25)36-17-6-13-31(30(36)38)14-19-33(20-15-31)29(37)24-8-3-2-4-9-24/h10-11,21,23-24,26H,2-9,12-20,22H2,1H3/t23-,26-/m0/s1
UniProtKB/TrEMBL

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US Patent
0.700n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108302
PNG
(US8604046, 82)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1S/C29H43FN4O3/c1-21-7-5-6-14-33(21)23-10-15-32(20-23)22-8-9-25(24(30)19-22)34-18-13-29(26(34)35)11-16-31(17-12-29)27(36)37-28(2,3)4/h8-9,19,21,23H,5-7,10-18,20H2,1-4H3/t21-,23-/m0/s1
UniProtKB/TrEMBL

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US Patent
4.30n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108318
PNG
(US8604046, 98)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC4CCOCC4)CC3)C2=O)c(F)c1
Show InChI InChI=1S/C30H45FN4O2/c1-23-4-2-3-13-34(23)26-7-14-33(22-26)25-5-6-28(27(31)20-25)35-17-12-30(29(35)36)10-15-32(16-11-30)21-24-8-18-37-19-9-24/h5-6,20,23-24,26H,2-4,7-19,21-22H2,1H3/t23-,26-/m0/s1
UniProtKB/TrEMBL

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US Patent
4.60n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair