BindingDB logo
myBDB logout

8 similar compounds to monomer 108283

Compile data set for download or QSAR
Wt: 410.5
BDBM108282
Wt: 452.6
BDBM108291
Wt: 506.7
BDBM108292
Wt: 450.6
BDBM108293
Wt: 480.6
BDBM108294
Wt: 396.5
BDBM108306
Wt: 369.5
BDBM50442642
Wt: 367.5
BDBM50442648

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 108282,108291,108292,108293,108294,108306,50442642,50442648   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108294
PNG
(US8604046, 74)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCCC2(CCN(CC2)C2CCOCC2)C1=O
Show InChI InChI=1S/C29H44N4O2/c1-23-4-2-15-32(23)27-9-17-31(22-27)24-5-7-26(8-6-24)33-16-3-12-29(28(33)34)13-18-30(19-14-29)25-10-20-35-21-11-25/h5-8,23,25,27H,2-4,9-22H2,1H3/t23-,27-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.0400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108282
PNG
(US8604046, 62)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCNCC3)C2=O)c(C)c1
Show InChI InChI=1S/C25H38N4O/c1-19-17-21(27-16-8-22(18-27)28-14-3-5-20(28)2)6-7-23(19)29-15-4-9-25(24(29)30)10-12-26-13-11-25/h6-7,17,20,22,26H,3-5,8-16,18H2,1-2H3/t20-,22-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.0700n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108292
PNG
(US8604046, 72)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCCC3(CCN(CC4CCCCC4)CC3)C2=O)c(C)c1
Show InChI InChI=1S/C32H50N4O/c1-25-22-28(34-19-13-29(24-34)35-17-6-8-26(35)2)11-12-30(25)36-18-7-14-32(31(36)37)15-20-33(21-16-32)23-27-9-4-3-5-10-27/h11-12,22,26-27,29H,3-10,13-21,23-24H2,1-2H3/t26-,29-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.200n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108293
PNG
(US8604046, 73)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCCC2(CCN(CC3CC3)CC2)C1=O
Show InChI InChI=1S/C28H42N4O/c1-22-4-2-15-31(22)26-11-17-30(21-26)24-7-9-25(10-8-24)32-16-3-12-28(27(32)33)13-18-29(19-14-28)20-23-5-6-23/h7-10,22-23,26H,2-6,11-21H2,1H3/t22-,26-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.200n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108291
PNG
(US8604046, 71)
Show SMILES CC(C)N1CCC2(CCCN(C2=O)c2ccc(cc2C)N2CC[C@@H](C2)N2CCC[C@@H]2C)CC1
Show InChI InChI=1S/C28H44N4O/c1-21(2)29-17-12-28(13-18-29)11-6-15-32(27(28)33)26-9-8-24(19-22(26)3)30-16-10-25(20-30)31-14-5-7-23(31)4/h8-9,19,21,23,25H,5-7,10-18,20H2,1-4H3/t23-,25-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Macaca mulatta (Rhesus macaque))
BDBM108306
PNG
(US8604046, 86)
Show SMILES C[C@H]1CCCCN1[C@H]1CCN(C1)c1ccc(cc1)N1CCC2(CCNCC2)C1=O
Show InChI InChI=1S/C24H36N4O/c1-19-4-2-3-15-27(19)22-9-16-26(18-22)20-5-7-21(8-6-20)28-17-12-24(23(28)29)10-13-25-14-11-24/h5-8,19,22,25H,2-4,9-18H2,1H3/t19-,22-/m0/s1
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
0.400n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...


US Patent US8604046 (2013)


BindingDB Entry DOI: 10.7270/Q2W957TB
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442648
PNG
(CHEMBL2441664)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2CC3CCC2C3)cc1
Show InChI InChI=1S/C23H33N3O/c1-16-3-2-11-26(16)21-10-12-25(15-21)20-8-6-19(7-9-20)24-23(27)22-14-17-4-5-18(22)13-17/h6-9,16-18,21-22H,2-5,10-15H2,1H3,(H,24,27)
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.006
BindingDB Entry DOI: 10.7270/Q24T6KT6
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442642
PNG
(CHEMBL2441650)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2C(C)(C)C2(C)C)cc1
Show InChI InChI=1S/C23H35N3O/c1-16-7-6-13-26(16)19-12-14-25(15-19)18-10-8-17(9-11-18)24-21(27)20-22(2,3)23(20,4)5/h8-11,16,19-20H,6-7,12-15H2,1-5H3,(H,24,27)
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
144n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.006
BindingDB Entry DOI: 10.7270/Q24T6KT6
More data for this
Ligand-Target Pair