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36 similar compounds to monomer 50193995

Wt: 324.3
BDBM109863
Wt: 310.3
BDBM109865
Wt: 310.3
BDBM109868
Wt: 324.3
BDBM109869
Wt: 324.3
BDBM109871
Wt: 324.3
BDBM109873
Wt: 296.3
BDBM109874
Wt: 324.3
BDBM109875
Wt: 310.3
BDBM109880
Wt: 338.4
BDBM109884
Wt: 324.3
BDBM109889
Wt: 324.3
BDBM109890
Wt: 324.3
BDBM109894
Wt: 338.4
BDBM109897
Wt: 324.3
BDBM109909
Displayed 1 to 15 (of 36 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 109863,109865,109868,109869,109871,109873,109874,109875,109880,109884,109889,109890,109894,109897,109909   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 3.40n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 4.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
PDB

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n/an/a 7.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
PDB

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n/an/a 5.80n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109871
PNG
(US8609647, 14 | US8609647, 20)
Show SMILES CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 41n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 7.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109873
PNG
(US8609647, 16)
Show SMILES CC1CN(CC2(CCN2C(=O)CC#N)C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-8-17(4-7-23(17)14(24)2-5-18)10-22(9-12)16-13-3-6-19-15(13)20-11-21-16/h3,6,11-12H,2,4,7-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 58n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109874
PNG
(US8609647, 17)
Show SMILES O=C(CC#N)N1CCC11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H16N6O/c16-5-1-12(22)21-8-4-15(21)3-7-20(9-15)14-11-2-6-17-13(11)18-10-19-14/h2,6,10H,1,3-4,7-9H2,(H,17,18,19)
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n/an/a 87n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109875
PNG
(US8609647, 18)
Show SMILES CC1CCC2(CCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-2-5-17(6-9-23(17)14(24)3-7-18)10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 410n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
PDB

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n/an/a 400n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109871
PNG
(US8609647, 14 | US8609647, 20)
Show SMILES CC1CC2(CCCN(C2)c2ncnc3[nH]ccc23)N1C(=O)CC#N
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(23(12)14(24)3-6-18)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 100n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
PDB

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n/an/a 21n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109880
PNG
(US8609647, 24)
Show SMILES CC1N(CCC11CCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-16(5-9-22(16)13(23)2-6-17)4-8-21(11)15-12-3-7-18-14(12)19-10-20-15/h3,7,10-11H,2,4-5,8-9H2,1H3,(H,18,19,20)
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n/an/a 130n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
PDB

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n/an/a 230n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109884
PNG
(US8609647, 28)
Show SMILES CC1(C)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c1-17(2)10-24(14(25)4-7-19)18(17)6-3-9-23(11-18)16-13-5-8-20-15(13)21-12-22-16/h5,8,12H,3-4,6,9-11H2,1-2H3,(H,20,21,22)
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n/an/a 130n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109889
PNG
(US8609647, 33 | US8609647, 42)
Show SMILES CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 480n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109890
PNG
(US8609647, 34)
Show SMILES CC1N(CCC11CCCN1C(=O)CC#N)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-17(5-2-9-23(17)14(24)3-7-18)6-10-22(12)16-13-4-8-19-15(13)20-11-21-16/h4,8,11-12H,2-3,5-6,9-10H2,1H3,(H,19,20,21)
PDB

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n/an/a 36n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109894
PNG
(US8609647, 38)
Show SMILES CC1(C)CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-16(2)9-23(13(24)3-6-18)17(16)5-8-22(10-17)15-12-4-7-19-14(12)20-11-21-15/h4,7,11H,3,5,8-10H2,1-2H3,(H,19,20,21)
PDB

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n/an/a 150n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109897
PNG
(US8609647, 41)
Show SMILES CC1(C)CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O/c1-17(2)5-10-24(14(25)3-7-19)18(17)6-9-23(11-18)16-13-4-8-20-15(13)21-12-22-16/h4,8,12H,3,5-6,9-11H2,1-2H3,(H,20,21,22)
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n/an/a 90n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109889
PNG
(US8609647, 33 | US8609647, 42)
Show SMILES CC1CC2(CCCN2C(=O)CC#N)CN1c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-17(5-2-8-23(17)14(24)3-6-18)10-22(12)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 100n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109909
PNG
(US8609647, 54 | US8609647, 66)
Show SMILES CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)
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n/an/a 5.90n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 38n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109909
PNG
(US8609647, 54 | US8609647, 66)
Show SMILES CC1CCN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-4-8-23(14(24)2-6-18)17(12)5-9-22(10-17)16-13-3-7-19-15(13)20-11-21-16/h3,7,11-12H,2,4-5,8-10H2,1H3,(H,19,20,21)
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n/an/a 11n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109869
PNG
(US8609647, 7 | US8609647, 84)
Show SMILES O=C(CC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c18-7-3-14(24)23-10-2-6-17(23)5-1-9-22(11-17)16-13-4-8-19-15(13)20-12-21-16/h4,8,12H,1-3,5-6,9-11H2,(H,19,20,21)
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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 1n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 1.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM109865
PNG
(US8609647, 25 | US8609647, 3 | US8609647, 59)
Show SMILES O=C(CC#N)N1CCC11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c17-6-2-13(23)22-9-5-16(22)4-1-8-21(10-16)15-12-3-7-18-14(12)19-11-20-15/h3,7,11H,1-2,4-5,8-10H2,(H,18,19,20)
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n/an/a 2.20n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM109868
PNG
(US8609647, 19 | US8609647, 21 | US8609647, 6)
Show SMILES CC1CN(C(=O)CC#N)C11CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)
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n/an/a 2.10n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM109863
PNG
(US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...)
Show SMILES CC1CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
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n/an/a 4.70n/an/an/an/an/an/a



Japan Tobacco Inc.

US Patent


Assay Description
In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...


US Patent US8609647 (2013)


BindingDB Entry DOI: 10.7270/Q29C6W24
More data for this
Ligand-Target Pair