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44 similar compounds to monomer 11162

Wt: 389.3
BDBM11159
Wt: 389.3
BDBM11160
Wt: 339.3
BDBM11161
Wt: 457.3
BDBM11163
Wt: 403.3
BDBM13515
Wt: 405.7
BDBM15561
Wt: 435.4
BDBM15570
Wt: 447.3
BDBM15577
Wt: 407.3
BDBM126822
Purchase
Wt: 423.7
BDBM50210643
Wt: 371.3
BDBM50210645
Wt: 389.3
BDBM50210649
Wt: 387.7
BDBM50210650
Wt: 367.3
BDBM50210652
Wt: 407.3
BDBM50210653
Displayed 1 to 15 (of 44 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 11159,11160,11161,11163,13515,15561,15570,15577,126822,50210643,50210645,50210649,50210650,50210652,50210653   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 128n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


J Med Chem 51: 4359-69 (2008)


Article DOI: 10.1021/jm800219f
BindingDB Entry DOI: 10.7270/Q28915N5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 4.60E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 6.90E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
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n/an/a 7.20E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
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n/an/a 8.00E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 9.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 49-52 (2007)


Article DOI: 10.1016/j.bmcl.2006.09.099
BindingDB Entry DOI: 10.7270/Q2F47MC2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM13515
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[(8R)-8-meth...)
Show SMILES C[C@H]1N(CCn2c1nnc2C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H18F5N5O/c1-9-15-24-25-16(17(20,21)22)27(15)5-4-26(9)14(28)8-12(23)7-10-6-11(18)2-3-13(10)19/h2-3,6,9,12H,4-5,7-8,23H2,1H3/t9-,12-/m1/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 49-52 (2007)


Article DOI: 10.1016/j.bmcl.2006.09.099
BindingDB Entry DOI: 10.7270/Q2F47MC2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM15561
PNG
((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(Cl)ccc1F
Show InChI InChI=1S/C16H16ClF4N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 21n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2404-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.040
BindingDB Entry DOI: 10.7270/Q2M906WF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM15570
PNG
((3R)-3-amino-4-[2,5-difluoro-4-(methylsulfanyl)phe...)
Show SMILES CSc1cc(F)c(C[C@@H](N)CC(=O)N2CCn3c(C2)nnc3C(F)(F)F)cc1F
Show InChI InChI=1S/C17H18F5N5OS/c1-29-13-7-11(18)9(5-12(13)19)4-10(23)6-15(28)26-2-3-27-14(8-26)24-25-16(27)17(20,21)22/h5,7,10H,2-4,6,8,23H2,1H3/t10-/m1/s1
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n/an/a 780n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2404-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.040
BindingDB Entry DOI: 10.7270/Q2M906WF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM15577
PNG
(2-[(1R)-1-amino-2-(2,4,5-trifluorophenyl)ethyl]-1-...)
Show SMILES N[C@H](Cc1cc(F)c(F)cc1F)C(CC=C)C(=O)N1CCn2c(C1)nnc2C(F)(F)F
Show InChI InChI=1S/C19H19F6N5O/c1-2-3-11(15(26)7-10-6-13(21)14(22)8-12(10)20)17(31)29-4-5-30-16(9-29)27-28-18(30)19(23,24)25/h2,6,8,11,15H,1,3-5,7,9,26H2/t11?,15-/m1/s1
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n/an/a 2.00E+3n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2404-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.040
BindingDB Entry DOI: 10.7270/Q2M906WF
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM126822
PNG
(US8785477, Sitagliptin)
Show SMILES NC(CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2
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n/an/a 26.0n/an/an/an/an/an/a



Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd.

US Patent


Assay Description
Thoroughly mixed test compounds, enzyme and reaction buffer, preincubated the mixture for 15 minutes at 37 C. and then primed reaction by adding sub...


US Patent US8785477 (2014)


BindingDB Entry DOI: 10.7270/Q20K278Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210643
PNG
((R)-3-amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C16H15ClF5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
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n/an/a 84n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210645
PNG
((R)-3-amino-4-(4-fluorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)cc1
Show InChI InChI=1S/C16H17F4N5O/c17-11-3-1-10(2-4-11)7-12(21)8-14(26)24-5-6-25-13(9-24)22-23-15(25)16(18,19)20/h1-4,12H,5-9,21H2/t12-/m1/s1
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n/an/a 272n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210643
PNG
((R)-3-amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C16H15ClF5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM15561
PNG
((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(Cl)ccc1F
Show InChI InChI=1S/C16H16ClF4N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210649
PNG
((R)-3-amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(22)5-14(27)25-1-2-26-13(7-25)23-24-16(26)15(20)21/h4,6,9,15H,1-3,5,7,22H2/t9-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210650
PNG
((R)-3-amino-4-(3-chlorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cccc(Cl)c1
Show InChI InChI=1S/C16H17ClF3N5O/c17-11-3-1-2-10(6-11)7-12(21)8-14(26)24-4-5-25-13(9-24)22-23-15(25)16(18,19)20/h1-3,6,12H,4-5,7-9,21H2/t12-/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210652
PNG
((R)-3-amino-1-(3-ethyl-5,6-dihydro-[1,2,4]triazolo...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H20F3N5O/c1-2-15-22-23-16-9-24(3-4-25(15)16)17(26)7-11(21)5-10-6-13(19)14(20)8-12(10)18/h6,8,11H,2-5,7,9,21H2,1H3/t11-/m1/s1
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n/an/a 37n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50210653
PNG
((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1c(F)ccc(F)c1F
Show InChI InChI=1S/C16H15F6N5O/c17-10-1-2-11(18)14(19)9(10)5-8(23)6-13(28)26-3-4-27-12(7-26)24-25-15(27)16(20,21)22/h1-2,8H,3-7,23H2/t8-/m1/s1
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n/an/a 151n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210649
PNG
((R)-3-amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(22)5-14(27)25-1-2-26-13(7-25)23-24-16(26)15(20)21/h4,6,9,15H,1-3,5,7,22H2/t9-/m1/s1
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n/an/a 8.60E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210650
PNG
((R)-3-amino-4-(3-chlorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cccc(Cl)c1
Show InChI InChI=1S/C16H17ClF3N5O/c17-11-3-1-2-10(6-11)7-12(21)8-14(26)24-4-5-25-13(9-24)22-23-15(25)16(18,19)20/h1-3,6,12H,4-5,7-9,21H2/t12-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210649
PNG
((R)-3-amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)F)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(22)5-14(27)25-1-2-26-13(7-25)23-24-16(26)15(20)21/h4,6,9,15H,1-3,5,7,22H2/t9-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15561
PNG
((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(Cl)ccc1F
Show InChI InChI=1S/C16H16ClF4N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210652
PNG
((R)-3-amino-1-(3-ethyl-5,6-dihydro-[1,2,4]triazolo...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H20F3N5O/c1-2-15-22-23-16-9-24(3-4-25(15)16)17(26)7-11(21)5-10-6-13(19)14(20)8-12(10)18/h6,8,11H,2-5,7,9,21H2,1H3/t11-/m1/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210643
PNG
((R)-3-amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C16H15ClF5N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210653
PNG
((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1c(F)ccc(F)c1F
Show InChI InChI=1S/C16H15F6N5O/c17-10-1-2-11(18)14(19)9(10)5-8(23)6-13(28)26-3-4-27-12(7-26)24-25-15(27)16(20,21)22/h1-2,8H,3-7,23H2/t8-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 6.90E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210645
PNG
((R)-3-amino-4-(4-fluorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)cc1
Show InChI InChI=1S/C16H17F4N5O/c17-11-3-1-10(2-4-11)7-12(21)8-14(26)24-5-6-25-13(9-24)22-23-15(25)16(18,19)20/h1-4,12H,5-9,21H2/t12-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210645
PNG
((R)-3-amino-4-(4-fluorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)cc1
Show InChI InChI=1S/C16H17F4N5O/c17-11-3-1-10(2-4-11)7-12(21)8-14(26)24-5-6-25-13(9-24)22-23-15(25)16(18,19)20/h1-4,12H,5-9,21H2/t12-/m1/s1
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n/an/a 6.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210653
PNG
((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1c(F)ccc(F)c1F
Show InChI InChI=1S/C16H15F6N5O/c17-10-1-2-11(18)14(19)9(10)5-8(23)6-13(28)26-3-4-27-12(7-26)24-25-15(27)16(20,21)22/h1-2,8H,3-7,23H2/t8-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 128n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50210652
PNG
((R)-3-amino-1-(3-ethyl-5,6-dihydro-[1,2,4]triazolo...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H20F3N5O/c1-2-15-22-23-16-9-24(3-4-25(15)16)17(26)7-11(21)5-10-6-13(19)14(20)8-12(10)18/h6,8,11H,2-5,7,9,21H2,1H3/t11-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50210650
PNG
((R)-3-amino-4-(3-chlorophenyl)-1-(3-(trifluorometh...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cccc(Cl)c1
Show InChI InChI=1S/C16H17ClF3N5O/c17-11-3-1-2-10(6-11)7-12(21)8-14(26)24-4-5-25-13(9-24)22-23-15(25)16(18,19)20/h1-3,6,12H,4-5,7-9,21H2/t12-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15561
PNG
((3R)-3-amino-4-(5-chloro-2-fluorophenyl)-1-[3-(tri...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(Cl)ccc1F
Show InChI InChI=1S/C16H16ClF4N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
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n/an/a 9.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP9 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP8 activity


Bioorg Med Chem Lett 17: 3373-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.098
BindingDB Entry DOI: 10.7270/Q2W37W04
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
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n/an/a 128n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


J Med Chem 51: 4359-69 (2008)


Article DOI: 10.1021/jm800219f
BindingDB Entry DOI: 10.7270/Q28915N5
More data for this
Ligand-Target Pair
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