BindingDB logo
myBDB logout

14 similar compounds to monomer 50417932

Compile data set for download or QSAR
Wt: 331.3
BDBM111785
Wt: 359.4
BDBM111788
Wt: 316.3
BDBM50340725
Wt: 330.4
BDBM50340731
Wt: 332.3
BDBM50417933
Wt: 350.8
BDBM50417934
Wt: 332.3
BDBM50417937
Wt: 302.3
BDBM50417914
Wt: 302.3
BDBM50417915
Wt: 346.4
BDBM50417916
Wt: 332.3
BDBM50417917
Wt: 334.3
BDBM50417919
Wt: 334.3
BDBM50417920
Wt: 346.4
BDBM50417921

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 111785,111788,50340725,50340731,50417933,50417934,50417937,50417914,50417915,50417916,50417917,50417919,50417920,50417921   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417934
PNG
(CHEMBL1668590 | US8829009, 1.1(7))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H15ClN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.186n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417915
PNG
(CHEMBL1668586 | US8618114, 1.2.3(1))
Show SMILES CNc1nn2c(C)ccnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-16-14-12(13(15-2)17-18(10)14)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.240n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.257n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation


J Med Chem 54: 8161-73 (2011)


Article DOI: 10.1021/jm201079g
BindingDB Entry DOI: 10.7270/Q2X067F0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.260n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417916
PNG
(CHEMBL1668564 | US8618114, 1.2.5(1))
Show SMILES CNc1nn2c(C)cc(COC)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O3S/c1-11-9-12(10-23-3)18-16-14(15(17-2)19-20(11)16)24(21,22)13-7-5-4-6-8-13/h4-9H,10H2,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.269n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417917
PNG
(CHEMBL1668565 | US8618114, 1.2.6(1))
Show SMILES CNc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)19-15(17-10)13(14(16-2)18-19)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.282n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417920
PNG
(CHEMBL1668592 | US8829009, 1.1(3))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-8-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-11(16)5-7-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.398n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417933
PNG
(CHEMBL1668588 | US8618114, 1.2.7(1))
Show SMILES CNc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)17-15-13(14(16-2)18-19(10)15)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.479n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417919
PNG
(CHEMBL1668591 | US8829009, 1.1(5))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.501n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417914
PNG
(CHEMBL1668585 | US8618114, 1.2.2(1))
Show SMILES CNc1nn2ccc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-18-14(16-10)12(13(15-2)17-18)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.45n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417937
PNG
(CHEMBL1668594)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(O)cc1
Show InChI InChI=1S/C15H16N4O3S/c1-9-8-10(2)19-15(17-9)13(14(16-3)18-19)23(21,22)12-6-4-11(20)5-7-12/h4-8,20H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417921
PNG
(CHEMBL1668595)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C16H18N4O3S/c1-10-9-11(2)20-16(18-10)14(15(17-3)19-20)24(21,22)13-7-5-12(23-4)6-8-13/h5-9H,1-4H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.55n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...


Bioorg Med Chem 19: 1482-91 (2011)


Article DOI: 10.1016/j.bmc.2010.12.055
BindingDB Entry DOI: 10.7270/Q21G0NJS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340731
PNG
(CHEMBL1762569 | N,N,5,7-Tetramethyl-3-(phenylsulfo...)
Show SMILES CN(C)c1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O2S/c1-11-10-12(2)20-15(17-11)14(16(18-20)19(3)4)23(21,22)13-8-6-5-7-9-13/h5-10H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
14.5n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.04E+3n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417917
PNG
(CHEMBL1668565 | US8618114, 1.2.6(1))
Show SMILES CNc1nn2c(CO)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)19-15(17-10)13(14(16-2)18-19)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM111788
PNG
(US8618114, 1.2.22(3).HCl)
Show SMILES CNc1nn2c(C)c(CCN)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H21N5O2S/c1-11-14(9-10-18)12(2)22-17(20-11)15(16(19-3)21-22)25(23,24)13-7-5-4-6-8-13/h4-8H,9-10,18H2,1-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 45n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417915
PNG
(CHEMBL1668586 | US8618114, 1.2.3(1))
Show SMILES CNc1nn2c(C)ccnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-16-14-12(13(15-2)17-18(10)14)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.740n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417933
PNG
(CHEMBL1668588 | US8618114, 1.2.7(1))
Show SMILES CNc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)17-15-13(14(16-2)18-19(10)15)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.880n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM111785
PNG
(US8618114, 1.2.22(1).HCl)
Show SMILES CNc1nn2c(C)c(N)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H17N5O2S/c1-9-12(16)10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)11-7-5-4-6-8-11/h4-8H,16H2,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.670n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM111788
PNG
(US8618114, 1.2.22(3).HCl)
Show SMILES CNc1nn2c(C)c(CCN)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H21N5O2S/c1-11-14(9-10-18)12(2)22-17(20-11)15(16(19-3)21-22)25(23,24)13-7-5-4-6-8-13/h4-8H,9-10,18H2,1-3H3,(H,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.645n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...


US Patent US8829009 (2014)


BindingDB Entry DOI: 10.7270/Q2TH8KC7
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50340731
PNG
(CHEMBL1762569 | N,N,5,7-Tetramethyl-3-(phenylsulfo...)
Show SMILES CN(C)c1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O2S/c1-11-10-12(2)20-15(17-11)14(16(18-20)19(3)4)23(21,22)13-8-6-5-7-9-13/h5-10H,1-4H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a 1.18E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...


US Patent US8829009 (2014)


BindingDB Entry DOI: 10.7270/Q2TH8KC7
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417920
PNG
(CHEMBL1668592 | US8829009, 1.1(3))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-8-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-11(16)5-7-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...


US Patent US8829009 (2014)


BindingDB Entry DOI: 10.7270/Q2TH8KC7
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417919
PNG
(CHEMBL1668591 | US8829009, 1.1(5))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C15H15FN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...


US Patent US8829009 (2014)


BindingDB Entry DOI: 10.7270/Q2TH8KC7
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417934
PNG
(CHEMBL1668590 | US8829009, 1.1(7))
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H15ClN4O2S/c1-9-7-10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)12-6-4-5-11(16)8-12/h4-8H,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of general formula 1 towards 5-HT6 receptors. Compounds of general formula 1 were tested for thei...


US Patent US8829009 (2014)


BindingDB Entry DOI: 10.7270/Q2TH8KC7
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417916
PNG
(CHEMBL1668564 | US8618114, 1.2.5(1))
Show SMILES CNc1nn2c(C)cc(COC)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H18N4O3S/c1-11-9-12(10-23-3)18-16-14(15(17-2)19-20(11)16)24(21,22)13-7-5-4-6-8-13/h4-9H,10H2,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.13E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50340725
PNG
(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Show SMILES CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O2S/c1-10-9-11(2)19-15(17-10)13(14(16-3)18-19)22(20,21)12-7-5-4-6-8-12/h4-9H,1-3H3,(H,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human ERG by patch clamp method


Eur J Med Chem 46: 1189-97 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.038
BindingDB Entry DOI: 10.7270/Q2HT2PMN
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417915
PNG
(CHEMBL1668586 | US8618114, 1.2.3(1))
Show SMILES CNc1nn2c(C)ccnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-16-14-12(13(15-2)17-18(10)14)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417914
PNG
(CHEMBL1668585 | US8618114, 1.2.2(1))
Show SMILES CNc1nn2ccc(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H14N4O2S/c1-10-8-9-18-14(16-10)12(13(15-2)17-18)21(19,20)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,15,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM50417933
PNG
(CHEMBL1668588 | US8618114, 1.2.7(1))
Show SMILES CNc1nn2c(C)cc(CO)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H16N4O3S/c1-10-8-11(9-20)17-15-13(14(16-2)18-19(10)15)23(21,22)12-6-4-3-5-7-12/h3-8,20H,9H2,1-2H3,(H,16,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 19n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (Human))
BDBM111785
PNG
(US8618114, 1.2.22(1).HCl)
Show SMILES CNc1nn2c(C)c(N)c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H17N5O2S/c1-9-12(16)10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)11-7-5-4-6-8-11/h4-8H,16H2,1-3H3,(H,17,19)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11.3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
Determination of antagonistic activity of compounds of the general formula 1 towards 5-HT6 receptors. Compounds of the general formula 1 were tested ...


US Patent US8618114 (2013)


BindingDB Entry DOI: 10.7270/Q2B56HD9
More data for this
Ligand-Target Pair