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14 similar compounds to monomer 111913

Wt: 387.4
BDBM111891
Wt: 412.4
BDBM111894
Wt: 411.4
BDBM111895
Wt: 387.4
BDBM111897
Wt: 376.4
BDBM111907
Wt: 387.4
BDBM111912
Wt: 455.4
BDBM111914
Wt: 455.4
BDBM111915
Wt: 455.4
BDBM111916
Wt: 388.4
BDBM111926
Wt: 457.5
BDBM111931
Wt: 417.4
BDBM111932
Wt: 421.8
BDBM111933
Wt: 401.4
BDBM111934

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 111891,111894,111895,111897,111907,111912,111914,111915,111916,111926,111931,111932,111933,111934   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111891
PNG
(US8623901, 219)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccnc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-10-29-11-8-17)21(19)25-20(26-22)12-15-4-1-2-6-18(15)16-5-3-9-23-13-16/h1-6,9,13-14,17H,7-8,10-12H2,(H,25,26,28)
PDB
MMDB

KEGG

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US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111894
PNG
(US8623901, 221)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccc(nc2)C#N)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C23H20N6O2/c24-12-17-6-5-16(13-25-17)19-4-2-1-3-15(19)11-21-27-22-20(23(30)28-21)14-26-29(22)18-7-9-31-10-8-18/h1-6,13-14,18H,7-11H2,(H,27,28,30)
PDB
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US Patent
n/an/a 6n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111895
PNG
(US8623901, 222)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccc(cc2)C#N)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C24H21N5O2/c25-14-16-5-7-17(8-6-16)20-4-2-1-3-18(20)13-22-27-23-21(24(30)28-22)15-26-29(23)19-9-11-31-12-10-19/h1-8,15,19H,9-13H2,(H,27,28,30)
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US Patent
n/an/a 15n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111897
PNG
(US8623901, 224)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccncc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-11-29-12-8-17)21(19)25-20(26-22)13-16-3-1-2-4-18(16)15-5-9-23-10-6-15/h1-6,9-10,14,17H,7-8,11-13H2,(H,25,26,28)
PDB
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US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111907
PNG
(US8623901, 230-5)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cc[nH]n2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C20H20N6O2/c27-20-16-12-22-26(14-6-9-28-10-7-14)19(16)23-18(24-20)11-13-3-1-2-4-15(13)17-5-8-21-25-17/h1-5,8,12,14H,6-7,9-11H2,(H,21,25)(H,23,24,27)
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US Patent
n/an/a 6n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111912
PNG
(US8623901, 240)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccccn2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-18-14-24-27(16-8-11-29-12-9-16)21(18)25-20(26-22)13-15-5-1-2-6-17(15)19-7-3-4-10-23-19/h1-7,10,14,16H,8-9,11-13H2,(H,25,26,28)
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US Patent
n/an/a 5n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111934
PNG
(US8623901, 263)
Show SMILES Cc1ccc(nc1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H23N5O2/c1-15-6-7-20(24-13-15)18-5-3-2-4-16(18)12-21-26-22-19(23(29)27-21)14-25-28(22)17-8-10-30-11-9-17/h2-7,13-14,17H,8-12H2,1H3,(H,26,27,29)
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US Patent
n/an/a 8n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111915
PNG
(US8623901, 243)
Show SMILES FC(F)(F)c1cccc(n1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H20F3N5O2/c24-23(25,26)19-7-3-6-18(28-19)16-5-2-1-4-14(16)12-20-29-21-17(22(32)30-20)13-27-31(21)15-8-10-33-11-9-15/h1-7,13,15H,8-12H2,(H,29,30,32)
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US Patent
n/an/a 18n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111916
PNG
(US8623901, 244)
Show SMILES FC(F)(F)c1ccnc(c1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H20F3N5O2/c24-23(25,26)15-5-8-27-19(12-15)17-4-2-1-3-14(17)11-20-29-21-18(22(32)30-20)13-28-31(21)16-6-9-33-10-7-16/h1-5,8,12-13,16H,6-7,9-11H2,(H,29,30,32)
PDB
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US Patent
n/an/a 26n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111926
PNG
(US8623901, 254)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccnn2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C21H20N6O2/c28-21-17-13-23-27(15-7-10-29-11-8-15)20(17)24-19(25-21)12-14-4-1-2-5-16(14)18-6-3-9-22-26-18/h1-6,9,13,15H,7-8,10-12H2,(H,24,25,28)
PDB
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US Patent
n/an/a 20n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111931
PNG
(US8623901, 260)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccc(OC3CCC3)n2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C26H27N5O3/c32-26-21-16-27-31(18-11-13-33-14-12-18)25(21)29-23(30-26)15-17-5-1-2-8-20(17)22-9-4-10-24(28-22)34-19-6-3-7-19/h1-2,4-5,8-10,16,18-19H,3,6-7,11-15H2,(H,29,30,32)
PDB
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US Patent
n/an/a 7n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111932
PNG
(US8623901, 261)
Show SMILES COc1ccc(nc1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H23N5O3/c1-30-17-6-7-20(24-13-17)18-5-3-2-4-15(18)12-21-26-22-19(23(29)27-21)14-25-28(22)16-8-10-31-11-9-16/h2-7,13-14,16H,8-12H2,1H3,(H,26,27,29)
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US Patent
n/an/a 4n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111933
PNG
(US8623901, 262)
Show SMILES Clc1ccc(nc1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H20ClN5O2/c23-15-5-6-19(24-12-15)17-4-2-1-3-14(17)11-20-26-21-18(22(29)27-20)13-25-28(21)16-7-9-30-10-8-16/h1-6,12-13,16H,7-11H2,(H,26,27,29)
PDB
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US Patent
n/an/a 20n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111914
PNG
(US8623901, 242)
Show SMILES FC(F)(F)c1ccc(nc1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H20F3N5O2/c24-23(25,26)15-5-6-19(27-12-15)17-4-2-1-3-14(17)11-20-29-21-18(22(32)30-20)13-28-31(21)16-7-9-33-10-8-16/h1-6,12-13,16H,7-11H2,(H,29,30,32)
PDB
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US Patent
n/an/a 23n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair