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11 similar compounds to monomer 111911

Wt: 387.4
BDBM111891
Wt: 411.4
BDBM111895
Wt: 387.4
BDBM111897
Wt: 418.4
BDBM111900
Wt: 405.4
BDBM111901
Wt: 390.4
BDBM111905
Wt: 405.4
BDBM111906
Wt: 376.4
BDBM111907
Wt: 388.4
BDBM111919
Wt: 388.4
BDBM111926
Wt: 310.3
BDBM50397850

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 111891,111895,111897,111900,111901,111905,111906,111907,111919,111926,50397850   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111891
PNG
(US8623901, 219)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccnc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-10-29-11-8-17)21(19)25-20(26-22)12-15-4-1-2-6-18(15)16-5-3-9-23-13-16/h1-6,9,13-14,17H,7-8,10-12H2,(H,25,26,28)
PDB
MMDB

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US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111895
PNG
(US8623901, 222)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccc(cc2)C#N)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C24H21N5O2/c25-14-16-5-7-17(8-6-16)20-4-2-1-3-18(20)13-22-27-23-21(24(30)28-22)15-26-29(23)19-9-11-31-12-10-19/h1-8,15,19H,9-13H2,(H,27,28,30)
PDB
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US Patent
n/an/a 15n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111897
PNG
(US8623901, 224)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccncc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-11-29-12-8-17)21(19)25-20(26-22)13-16-3-1-2-4-18(16)15-5-9-23-10-6-15/h1-6,9-10,14,17H,7-8,11-13H2,(H,25,26,28)
PDB
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US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111900
PNG
(US8623901, 227)
Show SMILES COc1ncc(cn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H22N6O3/c1-30-22-23-11-15(12-24-22)17-5-3-2-4-14(17)10-19-26-20-18(21(29)27-19)13-25-28(20)16-6-8-31-9-7-16/h2-5,11-13,16H,6-10H2,1H3,(H,26,27,29)
PDB
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US Patent
n/an/a 8n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111901
PNG
(US8623901, 228)
Show SMILES Fc1cc(ccn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H20FN5O2/c23-19-11-15(5-8-24-19)17-4-2-1-3-14(17)12-20-26-21-18(22(29)27-20)13-25-28(21)16-6-9-30-10-7-16/h1-5,8,11,13,16H,6-7,9-10,12H2,(H,26,27,29)
PDB
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US Patent
n/an/a 6n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM50397850
PNG
(CHEMBL2179093)
Show SMILES O=c1[nH]c(Cc2ccccc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C17H18N4O2/c22-17-14-11-18-21(13-6-8-23-9-7-13)16(14)19-15(20-17)10-12-4-2-1-3-5-12/h1-5,11,13H,6-10H2,(H,19,20,22)
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Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111906
PNG
(US8623901, 230-3)
Show SMILES Fc1ccc(cn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H20FN5O2/c23-19-6-5-15(12-24-19)17-4-2-1-3-14(17)11-20-26-21-18(22(29)27-20)13-25-28(21)16-7-9-30-10-8-16/h1-6,12-13,16H,7-11H2,(H,26,27,29)
PDB
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US Patent
n/an/a 11n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111907
PNG
(US8623901, 230-5)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cc[nH]n2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C20H20N6O2/c27-20-16-12-22-26(14-6-9-28-10-7-14)19(16)23-18(24-20)11-13-3-1-2-4-15(13)17-5-8-21-25-17/h1-5,8,12,14H,6-7,9-11H2,(H,21,25)(H,23,24,27)
PDB
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US Patent
n/an/a 6n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111919
PNG
(US8623901, 247)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccnnc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C21H20N6O2/c28-21-18-13-24-27(16-6-9-29-10-7-16)20(18)25-19(26-21)11-14-3-1-2-4-17(14)15-5-8-22-23-12-15/h1-5,8,12-13,16H,6-7,9-11H2,(H,25,26,28)
PDB
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US Patent
n/an/a 27n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111926
PNG
(US8623901, 254)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccnn2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C21H20N6O2/c28-21-17-13-23-27(15-7-10-29-11-8-15)20(17)24-19(25-21)12-14-4-1-2-5-16(14)18-6-3-9-22-26-18/h1-6,9,13,15H,7-8,10-12H2,(H,24,25,28)
PDB
MMDB

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US Patent
n/an/a 20n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 1C (PDE1C)


(Homo sapiens (Human))
BDBM50397850
PNG
(CHEMBL2179093)
Show SMILES O=c1[nH]c(Cc2ccccc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C17H18N4O2/c22-17-14-11-18-21(13-6-8-23-9-7-13)16(14)19-15(20-17)10-12-4-2-1-3-5-12/h1-5,11,13H,6-10H2,(H,19,20,22)
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Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111905
PNG
(US8623901, 230-2)
Show SMILES Cn1cc(cn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H22N6O2/c1-26-13-15(11-22-26)17-5-3-2-4-14(17)10-19-24-20-18(21(28)25-19)12-23-27(20)16-6-8-29-9-7-16/h2-5,11-13,16H,6-10H2,1H3,(H,24,25,28)
PDB
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US Patent
n/an/a 5n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair