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7 similar compounds to monomer 111901

Wt: 387.4
BDBM111891
Wt: 411.4
BDBM111895
Wt: 387.4
BDBM111897
Wt: 390.4
BDBM111905
Wt: 405.4
BDBM111906
Wt: 408.4
BDBM111911
Wt: 388.4
BDBM111919

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 111891,111895,111897,111905,111906,111911,111919   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111891
PNG
(US8623901, 219)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2cccnc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-10-29-11-8-17)21(19)25-20(26-22)12-15-4-1-2-6-18(15)16-5-3-9-23-13-16/h1-6,9,13-14,17H,7-8,10-12H2,(H,25,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111895
PNG
(US8623901, 222)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccc(cc2)C#N)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C24H21N5O2/c25-14-16-5-7-17(8-6-16)20-4-2-1-3-18(20)13-22-27-23-21(24(30)28-22)15-26-29(23)19-9-11-31-12-10-19/h1-8,15,19H,9-13H2,(H,27,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 15n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111897
PNG
(US8623901, 224)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccncc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-19-14-24-27(17-7-11-29-12-8-17)21(19)25-20(26-22)13-16-3-1-2-4-18(16)15-5-9-23-10-6-15/h1-6,9-10,14,17H,7-8,11-13H2,(H,25,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 12n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111919
PNG
(US8623901, 247)
Show SMILES O=c1[nH]c(Cc2ccccc2-c2ccnnc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C21H20N6O2/c28-21-18-13-24-27(16-6-9-29-10-7-16)20(18)25-19(26-21)11-14-3-1-2-4-17(14)15-5-8-22-23-12-15/h1-5,8,12-13,16H,6-7,9-11H2,(H,25,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 27n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111906
PNG
(US8623901, 230-3)
Show SMILES Fc1ccc(cn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H20FN5O2/c23-19-6-5-15(12-24-19)17-4-2-1-3-14(17)11-20-26-21-18(22(29)27-20)13-25-28(21)16-7-9-30-10-8-16/h1-6,12-13,16H,7-11H2,(H,26,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 11n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111911
PNG
(US8623901, 239)
Show SMILES Cn1cc(cn1)-c1ccc(F)cc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H21FN6O2/c1-27-12-14(10-23-27)17-3-2-15(22)8-13(17)9-19-25-20-18(21(29)26-19)11-24-28(20)16-4-6-30-7-5-16/h2-3,8,10-12,16H,4-7,9H2,1H3,(H,25,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111905
PNG
(US8623901, 230-2)
Show SMILES Cn1cc(cn1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H22N6O2/c1-26-13-15(11-22-26)17-5-3-2-4-14(17)10-19-24-20-18(21(28)25-19)12-23-27(20)16-6-8-29-9-7-16/h2-5,11-13,16H,6-10H2,1H3,(H,24,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 5n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair