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9 similar compounds to monomer 111930

Wt: 376.4
BDBM111908
Wt: 377.3
BDBM111920
Wt: 391.4
BDBM111921
Wt: 444.4
BDBM111922
Wt: 444.4
BDBM111923
Wt: 390.4
BDBM111924
Wt: 375.4
BDBM111925
Wt: 410.8
BDBM111928
Wt: 444.4
BDBM111929

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 111908,111920,111921,111922,111923,111924,111925,111928,111929   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111908
PNG
(US8623901, 231)
Show SMILES O=c1[nH]c(Cc2ccccc2-n2cccn2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C20H20N6O2/c27-20-16-13-22-26(15-6-10-28-11-7-15)19(16)23-18(24-20)12-14-4-1-2-5-17(14)25-9-3-8-21-25/h1-5,8-9,13,15H,6-7,10-12H2,(H,23,24,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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US Patent
n/an/a 18n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111920
PNG
(US8623901, 248)
Show SMILES O=c1[nH]c(Cc2ccccc2-n2cncn2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C19H19N7O2/c27-19-15-10-21-26(14-5-7-28-8-6-14)18(15)23-17(24-19)9-13-3-1-2-4-16(13)25-12-20-11-22-25/h1-4,10-12,14H,5-9H2,(H,23,24,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
US Patent
n/an/a 45n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111921
PNG
(US8623901, 249)
Show SMILES Cc1ncn(n1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C20H21N7O2/c1-13-21-12-26(25-13)17-5-3-2-4-14(17)10-18-23-19-16(20(28)24-18)11-22-27(19)15-6-8-29-9-7-15/h2-5,11-12,15H,6-10H2,1H3,(H,23,24,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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GoogleScholar
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PC cid
PC sid
UniChem

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US Patent
n/an/a 28n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111922
PNG
(US8623901, 250)
Show SMILES FC(F)(F)c1cnn(c1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)14-10-25-29(12-14)17-4-2-1-3-13(17)9-18-27-19-16(20(31)28-18)11-26-30(19)15-5-7-32-8-6-15/h1-4,10-12,15H,5-9H2,(H,27,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

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US Patent
n/an/a 24n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111929
PNG
(US8623901, 257)
Show SMILES FC(F)(F)c1ccc(c(Cc2nc3n(ncc3c(=O)[nH]2)C2CCOCC2)c1)-n1cccn1
Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)14-2-3-17(29-7-1-6-25-29)13(10-14)11-18-27-19-16(20(31)28-18)12-26-30(19)15-4-8-32-9-5-15/h1-3,6-7,10,12,15H,4-5,8-9,11H2,(H,27,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem

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AffyNet 
US Patent
n/an/a 31n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111924
PNG
(US8623901, 252)
Show SMILES Cc1ccn(n1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H22N6O2/c1-14-6-9-26(25-14)18-5-3-2-4-15(18)12-19-23-20-17(21(28)24-19)13-22-27(20)16-7-10-29-11-8-16/h2-6,9,13,16H,7-8,10-12H2,1H3,(H,23,24,28)
PDB
MMDB

KEGG

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US Patent
n/an/a 11n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111925
PNG
(US8623901, 253)
Show SMILES O=c1[nH]c(Cc2ccccc2-n2cccc2)nc2n(ncc12)C1CCOCC1
Show InChI InChI=1S/C21H21N5O2/c27-21-17-14-22-26(16-7-11-28-12-8-16)20(17)23-19(24-21)13-15-5-1-2-6-18(15)25-9-3-4-10-25/h1-6,9-10,14,16H,7-8,11-13H2,(H,23,24,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

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US Patent
n/an/a 34n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111928
PNG
(US8623901, 256)
Show SMILES Clc1ccc(c(Cc2nc3n(ncc3c(=O)[nH]2)C2CCOCC2)c1)-n1cccn1
Show InChI InChI=1S/C20H19ClN6O2/c21-14-2-3-17(26-7-1-6-22-26)13(10-14)11-18-24-19-16(20(28)25-18)12-23-27(19)15-4-8-29-9-5-15/h1-3,6-7,10,12,15H,4-5,8-9,11H2,(H,24,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 5n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (human))
BDBM111923
PNG
(US8623901, 251)
Show SMILES FC(F)(F)c1ccn(n1)-c1ccccc1Cc1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)17-5-8-29(28-17)16-4-2-1-3-13(16)11-18-26-19-15(20(31)27-18)12-25-30(19)14-6-9-32-10-7-14/h1-5,8,12,14H,6-7,9-11H2,(H,26,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 38n/an/an/an/a7.50



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...


US Patent US8623901 (2014)

More data for this
Ligand-Target Pair