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| Wt: 376.4 BDBM11548  | Wt: 394.8 BDBM11552  | Wt: 416.5 BDBM11553  | Wt: 361.4 BDBM11554  |
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Collagenase (Homo sapiens (Human)) | BDBM11554 ((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11552 ((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | <2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11554 ((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11553 ((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11552 ((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | <3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity to MMP2 | Bioorg Med Chem Lett 16: 1028-31 (2006) Article DOI: 10.1016/j.bmcl.2005.10.078 BindingDB Entry DOI: 10.7270/Q26Q1WTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Inhibition of MMP2 | Bioorg Med Chem 17: 444-59 (2009) Article DOI: 10.1016/j.bmc.2008.11.067 BindingDB Entry DOI: 10.7270/Q2WH2QWZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11553 ((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11552 ((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11553 ((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11554 ((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 46.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 46.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Inhibition of MMP9 | Bioorg Med Chem 17: 444-59 (2009) Article DOI: 10.1016/j.bmc.2008.11.067 BindingDB Entry DOI: 10.7270/Q2WH2QWZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity to MMP9 | Bioorg Med Chem Lett 16: 1028-31 (2006) Article DOI: 10.1016/j.bmcl.2005.10.078 BindingDB Entry DOI: 10.7270/Q26Q1WTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Inhibition of MMP13 | Bioorg Med Chem 17: 444-59 (2009) Article DOI: 10.1016/j.bmc.2008.11.067 BindingDB Entry DOI: 10.7270/Q2WH2QWZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Collagenase (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity to MMP13 | Bioorg Med Chem Lett 16: 1028-31 (2006) Article DOI: 10.1016/j.bmcl.2005.10.078 BindingDB Entry DOI: 10.7270/Q26Q1WTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matrix metalloproteinase-1 (MMP1) (Homo sapiens (Human)) | BDBM11552 ((3R)-2-[(4-chloro-1,1-biphenyl-4-yl)methyl]-N-hydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 318 | -8.86 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matrix metalloproteinase-1 (MMP1) (Homo sapiens (Human)) | BDBM11554 ((3R)-N-hydroxy-1,1-dioxo-2-{[4-(pyridin-4-yl)pheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 1.09E+3 | -8.13 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matrix metalloproteinase-1 (MMP1) (Homo sapiens (Human)) | BDBM11553 ((3R)-2-[(4-tert-butyl-1,1-biphenyl-4-yl)methyl]-N-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 3.17E+3 | -7.50 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matrix metalloproteinase-1 (MMP1) (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >4.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity to MMP1 | Bioorg Med Chem Lett 16: 1028-31 (2006) Article DOI: 10.1016/j.bmcl.2005.10.078 BindingDB Entry DOI: 10.7270/Q26Q1WTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Matrix metalloproteinase-1 (MMP1) (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >4.95E+3 | >-7.23 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Bristol-Myers Squibb Company | Assay Description The enzymatic activities of MMPs were determined with recombinant human version catalytic domains and a fluorogenic peptide substrate. Fluorescence m... | J Med Chem 47: 2981-3 (2004) Article DOI: 10.1021/jm049833g BindingDB Entry DOI: 10.7270/Q29W0CQB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ADAM17 (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory activity against TACE | Bioorg Med Chem Lett 16: 1028-31 (2006) Article DOI: 10.1016/j.bmcl.2005.10.078 BindingDB Entry DOI: 10.7270/Q26Q1WTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ADAM17 (Homo sapiens (Human)) | BDBM11548 (CHEMBL100570 | N-hydroxy-2-[(4-methoxy-1,1-bipheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Inhibition of TACE | Bioorg Med Chem 17: 444-59 (2009) Article DOI: 10.1016/j.bmc.2008.11.067 BindingDB Entry DOI: 10.7270/Q2WH2QWZ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
