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13 similar compounds to monomer 116440

Compile data set for download or QSAR
Wt: 322.3
BDBM116408
Wt: 427.4
BDBM116692
Wt: 337.3
BDBM116415
Wt: 337.3
BDBM116438
Wt: 351.4
BDBM116503
Wt: 337.3
BDBM116507
Wt: 351.4
BDBM116533
Wt: 351.4
BDBM116534
Wt: 351.4
BDBM116540
Wt: 365.4
BDBM116544
Wt: 365.4
BDBM116582
Wt: 337.3
BDBM116611
Wt: 337.3
BDBM116331

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 116408,116692,116415,116438,116503,116507,116533,116534,116540,116544,116582,116611,116331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116331
PNG
(US8637532, 12 | US8637532, 242)
Show SMILES COc1cccc(c1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-5-2-4-11(8-12)15(9-19)23-18-14-7-3-6-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 3.40n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM116438
PNG
(US8637532, 119)
Show SMILES COc1ccccc1C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-15-8-3-2-5-11(15)14(9-19)23-18-13-7-4-6-12(17(20)24)16(13)21-10-22-18/h2-8,10,14H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 48n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116415
PNG
(US8637532, 96)
Show SMILES COc1ccc(cc1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-7-5-11(6-8-12)15(9-19)23-18-14-4-2-3-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 0.700n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116438
PNG
(US8637532, 119)
Show SMILES COc1ccccc1C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-15-8-3-2-5-11(15)14(9-19)23-18-13-7-4-6-12(17(20)24)16(13)21-10-22-18/h2-8,10,14H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 5.70n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116503
PNG
(US8637532, 184)
Show SMILES CNCC(Nc1ncnc2c(cc(OC)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-16(12-6-4-3-5-7-12)24-19-15-9-13(26-2)8-14(18(20)25)17(15)22-11-23-19/h3-9,11,16,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 0.120n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116507
PNG
(US8637532, 188)
Show SMILES COc1cc(C(N)=O)c2ncnc(N[C@H](CN)c3ccccc3)c2c1
Show InChI InChI=1S/C18H19N5O2/c1-25-12-7-13(17(20)24)16-14(8-12)18(22-10-21-16)23-15(9-19)11-5-3-2-4-6-11/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)/t15-/m1/s1
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n/an/a 0.390n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116533
PNG
(US8637532, 221)
Show SMILES CNCC(Nc1ncnc2c(ccc(OC)c12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-14(12-6-4-3-5-7-12)24-19-16-15(26-2)9-8-13(18(20)25)17(16)22-11-23-19/h3-9,11,14,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 1.30n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116534
PNG
(US8637532, 222)
Show SMILES CNCC(Nc1ncnc2c(cccc12)C(N)=O)c1ccc(OC)cc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-16(12-6-8-13(26-2)9-7-12)24-19-15-5-3-4-14(18(20)25)17(15)22-11-23-19/h3-9,11,16,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 1.30n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116540
PNG
(US8637532, 230)
Show SMILES CNC[C@@H](Nc1ncnc2c(cc(OC)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-16(12-6-4-3-5-7-12)24-19-15-9-13(26-2)8-14(18(20)25)17(15)22-11-23-19/h3-9,11,16,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)/t16-/m1/s1
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n/an/a 2.20n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116544
PNG
(US8637532, 235)
Show SMILES CCNC[C@@H](Nc1ncnc2c(cc(OC)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C20H23N5O2/c1-3-22-11-17(13-7-5-4-6-8-13)25-20-16-10-14(27-2)9-15(19(21)26)18(16)23-12-24-20/h4-10,12,17,22H,3,11H2,1-2H3,(H2,21,26)(H,23,24,25)/t17-/m1/s1
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n/an/a 2.80n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116331
PNG
(US8637532, 12 | US8637532, 242)
Show SMILES COc1cccc(c1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-5-2-4-11(8-12)15(9-19)23-18-14-7-3-6-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 3.40n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116582
PNG
(US8637532, 274)
Show SMILES COc1cccc(c1)C(CN(C)C)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H23N5O2/c1-25(2)11-17(13-6-4-7-14(10-13)27-3)24-20-16-9-5-8-15(19(21)26)18(16)22-12-23-20/h4-10,12,17H,11H2,1-3H3,(H2,21,26)(H,22,23,24)
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n/an/a 6.80n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116611
PNG
(US8637532, 305)
Show SMILES CNCC(Nc1ncnc2c(cc(O)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C18H19N5O2/c1-20-9-15(11-5-3-2-4-6-11)23-18-14-8-12(24)7-13(17(19)25)16(14)21-10-22-18/h2-8,10,15,20,24H,9H2,1H3,(H2,19,25)(H,21,22,23)
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n/an/a 11n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116692
PNG
(US8637532, 396)
Show SMILES CNCC(Nc1ncnc2c(cc(OCc3ccccc3)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c1-27-14-22(18-10-6-3-7-11-18)30-25-21-13-19(32-15-17-8-4-2-5-9-17)12-20(24(26)31)23(21)28-16-29-25/h2-13,16,22,27H,14-15H2,1H3,(H2,26,31)(H,28,29,30)
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n/an/a 28n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116331
PNG
(US8637532, 12 | US8637532, 242)
Show SMILES COc1cccc(c1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-5-2-4-11(8-12)15(9-19)23-18-14-7-3-6-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 770n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116408
PNG
(US8637532, 89)
Show SMILES COc1cc(C(N)=O)c2ncnc(N[C@H](C)c3ccccc3)c2c1
Show InChI InChI=1S/C18H18N4O2/c1-11(12-6-4-3-5-7-12)22-18-15-9-13(24-2)8-14(17(19)23)16(15)20-10-21-18/h3-11H,1-2H3,(H2,19,23)(H,20,21,22)/t11-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116415
PNG
(US8637532, 96)
Show SMILES COc1ccc(cc1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-7-5-11(6-8-12)15(9-19)23-18-14-4-2-3-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116438
PNG
(US8637532, 119)
Show SMILES COc1ccccc1C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-15-8-3-2-5-11(15)14(9-19)23-18-13-7-4-6-12(17(20)24)16(13)21-10-22-18/h2-8,10,14H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116503
PNG
(US8637532, 184)
Show SMILES CNCC(Nc1ncnc2c(cc(OC)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-16(12-6-4-3-5-7-12)24-19-15-9-13(26-2)8-14(18(20)25)17(15)22-11-23-19/h3-9,11,16,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 230n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116507
PNG
(US8637532, 188)
Show SMILES COc1cc(C(N)=O)c2ncnc(N[C@H](CN)c3ccccc3)c2c1
Show InChI InChI=1S/C18H19N5O2/c1-25-12-7-13(17(20)24)16-14(8-12)18(22-10-21-16)23-15(9-19)11-5-3-2-4-6-11/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)/t15-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116533
PNG
(US8637532, 221)
Show SMILES CNCC(Nc1ncnc2c(ccc(OC)c12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-14(12-6-4-3-5-7-12)24-19-16-15(26-2)9-8-13(18(20)25)17(16)22-11-23-19/h3-9,11,14,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 670n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116534
PNG
(US8637532, 222)
Show SMILES CNCC(Nc1ncnc2c(cccc12)C(N)=O)c1ccc(OC)cc1
Show InChI InChI=1S/C19H21N5O2/c1-21-10-16(12-6-8-13(26-2)9-7-12)24-19-15-5-3-4-14(18(20)25)17(15)22-11-23-19/h3-9,11,16,21H,10H2,1-2H3,(H2,20,25)(H,22,23,24)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116544
PNG
(US8637532, 235)
Show SMILES CCNC[C@@H](Nc1ncnc2c(cc(OC)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C20H23N5O2/c1-3-22-11-17(13-7-5-4-6-8-13)25-20-16-10-14(27-2)9-15(19(21)26)18(16)23-12-24-20/h4-10,12,17,22H,3,11H2,1-2H3,(H2,21,26)(H,23,24,25)/t17-/m1/s1
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n/an/a 180n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116331
PNG
(US8637532, 12 | US8637532, 242)
Show SMILES COc1cccc(c1)C(CN)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O2/c1-25-12-5-2-4-11(8-12)15(9-19)23-18-14-7-3-6-13(17(20)24)16(14)21-10-22-18/h2-8,10,15H,9,19H2,1H3,(H2,20,24)(H,21,22,23)
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n/an/a 770n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116582
PNG
(US8637532, 274)
Show SMILES COc1cccc(c1)C(CN(C)C)Nc1ncnc2c(cccc12)C(N)=O
Show InChI InChI=1S/C20H23N5O2/c1-25(2)11-17(13-6-4-7-14(10-13)27-3)24-20-16-9-5-8-15(19(21)26)18(16)22-12-23-20/h4-10,12,17H,11H2,1-3H3,(H2,21,26)(H,22,23,24)
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n/an/a 570n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116611
PNG
(US8637532, 305)
Show SMILES CNCC(Nc1ncnc2c(cc(O)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C18H19N5O2/c1-20-9-15(11-5-3-2-4-6-11)23-18-14-8-12(24)7-13(17(19)25)16(14)21-10-22-18/h2-8,10,15,20,24H,9H2,1H3,(H2,19,25)(H,21,22,23)
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n/an/a 560n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM116692
PNG
(US8637532, 396)
Show SMILES CNCC(Nc1ncnc2c(cc(OCc3ccccc3)cc12)C(N)=O)c1ccccc1
Show InChI InChI=1S/C25H25N5O2/c1-27-14-22(18-10-6-3-7-11-18)30-25-21-13-19(32-15-17-8-4-2-5-9-17)12-20(24(26)31)23(21)28-16-29-25/h2-13,16,22,27H,14-15H2,1H3,(H2,26,31)(H,28,29,30)
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n/an/a 400n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzym...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM116408
PNG
(US8637532, 89)
Show SMILES COc1cc(C(N)=O)c2ncnc(N[C@H](C)c3ccccc3)c2c1
Show InChI InChI=1S/C18H18N4O2/c1-11(12-6-4-3-5-7-12)22-18-15-9-13(24-2)8-14(17(19)23)16(15)20-10-21-18/h3-11H,1-2H3,(H2,19,23)(H,20,21,22)/t11-/m1/s1
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n/an/a 48.9n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US8637532 (2014)


BindingDB Entry DOI: 10.7270/Q21G0JZX
More data for this
Ligand-Target Pair