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2 similar compounds to monomer 118213

Wt: 433.4
BDBM118212
Wt: 419.4
BDBM118214

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 118212,118214   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM118212
PNG
(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Show SMILES Cc1ncc(C#Cc2ccc3c(c2)occ(-c2ccc(NS(C)(=O)=O)cc2)c3=O)n1C
Show InChI InChI=1S/C23H19N3O4S/c1-15-24-13-19(26(15)2)10-4-16-5-11-20-22(12-16)30-14-21(23(20)27)17-6-8-18(9-7-17)25-31(3,28)29/h5-9,11-14,25H,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


Citation and Details
More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM118214
PNG
(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Show SMILES Cn1cnc(c1)C#Cc1ccc2c(c1)occ(-c1ccc(NS(C)(=O)=O)cc1)c2=O
Show InChI InChI=1S/C22H17N3O4S/c1-25-12-18(23-14-25)7-3-15-4-10-19-21(11-15)29-13-20(22(19)26)16-5-8-17(9-6-16)24-30(2,27)28/h4-6,8-14,24H,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 95n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase type B (MAO-B)


(Homo sapiens (Human))
BDBM118214
PNG
(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Show SMILES Cn1cnc(c1)C#Cc1ccc2c(c1)occ(-c1ccc(NS(C)(=O)=O)cc1)c2=O
Show InChI InChI=1S/C22H17N3O4S/c1-25-12-18(23-14-25)7-3-15-4-10-19-21(11-15)29-13-20(22(19)26)16-5-8-17(9-6-16)24-30(2,27)28/h4-6,8-14,24H,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase type A (MAO-A)


(Homo sapiens (Human))
BDBM118214
PNG
(US8673966, N-(4-(7-((1-methyl-1H-imidazol-4-yl)eth...)
Show SMILES Cn1cnc(c1)C#Cc1ccc2c(c1)occ(-c1ccc(NS(C)(=O)=O)cc1)c2=O
Show InChI InChI=1S/C22H17N3O4S/c1-25-12-18(23-14-25)7-3-15-4-10-19-21(11-15)29-13-20(22(19)26)16-5-8-17(9-6-16)24-30(2,27)28/h4-6,8-14,24H,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>8.65E+4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase type B (MAO-B)


(Homo sapiens (Human))
BDBM118212
PNG
(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Show SMILES Cc1ncc(C#Cc2ccc3c(c2)occ(-c2ccc(NS(C)(=O)=O)cc2)c3=O)n1C
Show InChI InChI=1S/C23H19N3O4S/c1-15-24-13-19(26(15)2)10-4-16-5-11-20-22(12-16)30-14-21(23(20)27)17-6-8-18(9-7-17)25-31(3,28)29/h5-9,11-14,25H,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase type A (MAO-A)


(Homo sapiens (Human))
BDBM118212
PNG
(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Show SMILES Cc1ncc(C#Cc2ccc3c(c2)occ(-c2ccc(NS(C)(=O)=O)cc2)c3=O)n1C
Show InChI InChI=1S/C23H19N3O4S/c1-15-24-13-19(26(15)2)10-4-16-5-11-20-22(12-16)30-14-21(23(20)27)17-6-8-18(9-7-17)25-31(3,28)29/h5-9,11-14,25H,1-3H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


Citation and Details
More data for this
Ligand-Target Pair