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68 molecules are shown

Compile data set for download or QSAR
Wt: 418.5
BDBM50128637
Wt: 448.5
BDBM50128638
Wt: 448.5
BDBM50128644
Wt: 418.5
BDBM50128646
Wt: 500.9
BDBM50128648
Wt: 531.0
BDBM50128649
Wt: 480.5
BDBM50128650
Wt: 438.9
BDBM50128651
Wt: 404.4
BDBM50128652
Wt: 370.4
BDBM50128653
Wt: 422.4
BDBM50128655
Wt: 410.8
BDBM50128656
Wt: 434.5
BDBM50128657
Wt: 432.5
BDBM50128660
Wt: 328.3
BDBM50128661
<<  First   |  Previous   |  Displayed 16 to 30 (of 68 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 62 hits for monomerid = 50128637,50128638,50128644,50128646,50128648,50128649,50128650,50128651,50128652,50128653,50128655,50128656,50128657,50128660,50128661   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of ADAMTS-4 (unknown origin)


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 420n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of ADAMTS-5 (unknown origin)


Bioorg Med Chem Lett 23: 2106-10 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.121
BindingDB Entry DOI: 10.7270/Q26974ZF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128657
PNG
(1-(3-methoxybenzyl)-N-hydroxy-4-(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2cccc(OC)c2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O6S/c1-28-17-6-8-19(9-7-17)30(26,27)21(20(24)22-25)10-12-23(13-11-21)15-16-4-3-5-18(14-16)29-2/h3-9,14,25H,10-13,15H2,1-2H3,(H,22,24)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128651
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-1-ethyl-N-hy...)
Show SMILES CCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H23ClN2O5S/c1-2-23-13-11-20(12-14-23,19(24)22-25)29(26,27)18-9-7-17(8-10-18)28-16-5-3-15(21)4-6-16/h3-10,25H,2,11-14H2,1H3,(H,22,24)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128649
PNG
(1-(4-methoxybenzyl)-4-(4-(4-chlorophenoxy)phenylsu...)
Show SMILES COc1ccc(CN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)cc1
Show InChI InChI=1S/C26H27ClN2O6S/c1-34-21-6-2-19(3-7-21)18-29-16-14-26(15-17-29,25(30)28-31)36(32,33)24-12-10-23(11-13-24)35-22-8-4-20(27)5-9-22/h2-13,31H,14-18H2,1H3,(H,28,30)
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n/an/a 492n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 55n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-3


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128661
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-methyl-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(C)CC1)C(=O)NO
Show InChI InChI=1S/C14H20N2O5S/c1-16-9-7-14(8-10-16,13(17)15-18)22(19,20)12-5-3-11(21-2)4-6-12/h3-6,18H,7-10H2,1-2H3,(H,15,17)
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n/an/a 5.11E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128660
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenyl-propyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O5S/c1-29-19-9-11-20(12-10-19)30(27,28)22(21(25)23-26)13-16-24(17-14-22)15-5-8-18-6-3-2-4-7-18/h2-4,6-7,9-12,26H,5,8,13-17H2,1H3,(H,23,25)
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128646
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-phenethyl-piperidi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-28-18-7-9-19(10-8-18)29(26,27)21(20(24)22-25)12-15-23(16-13-21)14-11-17-5-3-2-4-6-17/h2-10,25H,11-16H2,1H3,(H,22,24)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128646
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-phenethyl-piperidi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-28-18-7-9-19(10-8-18)29(26,27)21(20(24)22-25)12-15-23(16-13-21)14-11-17-5-3-2-4-6-17/h2-10,25H,11-16H2,1H3,(H,22,24)
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n/an/a 45n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128656
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypip...)
Show SMILES ONC(=O)C1(CCNCC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H19ClN2O5S/c19-13-1-3-14(4-2-13)26-15-5-7-16(8-6-15)27(24,25)18(17(22)21-23)9-11-20-12-10-18/h1-8,20,23H,9-12H2,(H,21,22)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128657
PNG
(1-(3-methoxybenzyl)-N-hydroxy-4-(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2cccc(OC)c2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O6S/c1-28-17-6-8-19(9-7-17)30(26,27)21(20(24)22-25)10-12-23(13-11-21)15-16-4-3-5-18(14-16)29-2/h3-9,14,25H,10-13,15H2,1-2H3,(H,22,24)
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n/an/a 213n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128644
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenoxy-propyl)...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCOc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-8-10-20(11-9-18)31(27,28)22(21(25)23-26)12-15-24(16-13-22)14-5-17-30-19-6-3-2-4-7-19/h2-4,6-11,26H,5,12-17H2,1H3,(H,23,25)
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n/an/a 4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128656
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypip...)
Show SMILES ONC(=O)C1(CCNCC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H19ClN2O5S/c19-13-1-3-14(4-2-13)26-15-5-7-16(8-6-15)27(24,25)18(17(22)21-23)9-11-20-12-10-18/h1-8,20,23H,9-12H2,(H,21,22)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128655
PNG
(1-(4-Fluoro-benzyl)-4-(4-methoxy-benzenesulfonyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(F)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H23FN2O5S/c1-28-17-6-8-18(9-7-17)29(26,27)20(19(24)22-25)10-12-23(13-11-20)14-15-2-4-16(21)5-3-15/h2-9,25H,10-14H2,1H3,(H,22,24)
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n/an/a 250n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128644
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenoxy-propyl)...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCOc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-8-10-20(11-9-18)31(27,28)22(21(25)23-26)12-15-24(16-13-22)14-5-17-30-19-6-3-2-4-7-19/h2-4,6-11,26H,5,12-17H2,1H3,(H,23,25)
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n/an/a 44n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128649
PNG
(1-(4-methoxybenzyl)-4-(4-(4-chlorophenoxy)phenylsu...)
Show SMILES COc1ccc(CN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)cc1
Show InChI InChI=1S/C26H27ClN2O6S/c1-34-21-6-2-19(3-7-21)18-29-16-14-26(15-17-29,25(30)28-31)36(32,33)24-12-10-23(11-13-24)35-22-8-4-20(27)5-9-22/h2-13,31H,14-18H2,1H3,(H,28,30)
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n/an/a 490n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128653
PNG
(1-Butyl-4-(4-methoxy-benzenesulfonyl)-piperidine-4...)
Show SMILES CCCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C17H26N2O5S/c1-3-4-11-19-12-9-17(10-13-19,16(20)18-21)25(22,23)15-7-5-14(24-2)6-8-15/h5-8,21H,3-4,9-13H2,1-2H3,(H,18,20)
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n/an/a 38n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128657
PNG
(1-(3-methoxybenzyl)-N-hydroxy-4-(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2cccc(OC)c2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O6S/c1-28-17-6-8-19(9-7-17)30(26,27)21(20(24)22-25)10-12-23(13-11-21)15-16-4-3-5-18(14-16)29-2/h3-9,14,25H,10-13,15H2,1-2H3,(H,22,24)
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n/an/a 9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128649
PNG
(1-(4-methoxybenzyl)-4-(4-(4-chlorophenoxy)phenylsu...)
Show SMILES COc1ccc(CN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)cc1
Show InChI InChI=1S/C26H27ClN2O6S/c1-34-21-6-2-19(3-7-21)18-29-16-14-26(15-17-29,25(30)28-31)36(32,33)24-12-10-23(11-13-24)35-22-8-4-20(27)5-9-22/h2-13,31H,14-18H2,1H3,(H,28,30)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128646
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-phenethyl-piperidi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-28-18-7-9-19(10-8-18)29(26,27)21(20(24)22-25)12-15-23(16-13-21)14-11-17-5-3-2-4-6-17/h2-10,25H,11-16H2,1H3,(H,22,24)
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n/an/a 9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128638
PNG
(1-(4-methoxyphenethyl)-N-hydroxy-4-(4-methoxypheny...)
Show SMILES COc1ccc(CCN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-5-3-17(4-6-18)11-14-24-15-12-22(13-16-24,21(25)23-26)31(27,28)20-9-7-19(30-2)8-10-20/h3-10,26H,11-16H2,1-2H3,(H,23,25)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128655
PNG
(1-(4-Fluoro-benzyl)-4-(4-methoxy-benzenesulfonyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(F)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H23FN2O5S/c1-28-17-6-8-18(9-7-17)29(26,27)20(19(24)22-25)10-12-23(13-11-20)14-15-2-4-16(21)5-3-15/h2-9,25H,10-14H2,1H3,(H,22,24)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128656
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypip...)
Show SMILES ONC(=O)C1(CCNCC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C18H19ClN2O5S/c19-13-1-3-14(4-2-13)26-15-5-7-16(8-6-15)27(24,25)18(17(22)21-23)9-11-20-12-10-18/h1-8,20,23H,9-12H2,(H,21,22)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128661
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-methyl-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(C)CC1)C(=O)NO
Show InChI InChI=1S/C14H20N2O5S/c1-16-9-7-14(8-10-16,13(17)15-18)22(19,20)12-5-3-11(21-2)4-6-12/h3-6,18H,7-10H2,1-2H3,(H,15,17)
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n/an/a 484n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128650
PNG
(1-Biphenyl-4-ylmethyl-4-(4-methoxy-benzenesulfonyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C26H28N2O5S/c1-33-23-11-13-24(14-12-23)34(31,32)26(25(29)27-30)15-17-28(18-16-26)19-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h2-14,30H,15-19H2,1H3,(H,27,29)
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n/an/a 610n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128650
PNG
(1-Biphenyl-4-ylmethyl-4-(4-methoxy-benzenesulfonyl...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(cc2)-c2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C26H28N2O5S/c1-33-23-11-13-24(14-12-23)34(31,32)26(25(29)27-30)15-17-28(18-16-26)19-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h2-14,30H,15-19H2,1H3,(H,27,29)
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n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128652
PNG
(1-Benzyl-4-(4-methoxy-benzenesulfonyl)-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H24N2O5S/c1-27-17-7-9-18(10-8-17)28(25,26)20(19(23)21-24)11-13-22(14-12-20)15-16-5-3-2-4-6-16/h2-10,24H,11-15H2,1H3,(H,21,23)
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n/an/a 492n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128651
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-1-ethyl-N-hy...)
Show SMILES CCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H23ClN2O5S/c1-2-23-13-11-20(12-14-23,19(24)22-25)29(26,27)18-9-7-17(8-10-18)28-16-5-3-15(21)4-6-16/h3-10,25H,2,11-14H2,1H3,(H,22,24)
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n/an/a 413n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128637
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(4-methyl-benzyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(C)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-16-3-5-17(6-4-16)15-23-13-11-21(12-14-23,20(24)22-25)29(26,27)19-9-7-18(28-2)8-10-19/h3-10,25H,11-15H2,1-2H3,(H,22,24)
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n/an/a 17n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128657
PNG
(1-(3-methoxybenzyl)-N-hydroxy-4-(4-methoxyphenylsu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2cccc(OC)c2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O6S/c1-28-17-6-8-19(9-7-17)30(26,27)21(20(24)22-25)10-12-23(13-11-21)15-16-4-3-5-18(14-16)29-2/h3-9,14,25H,10-13,15H2,1-2H3,(H,22,24)
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n/an/a 519n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 301n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128637
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(4-methyl-benzyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(C)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-16-3-5-17(6-4-16)15-23-13-11-21(12-14-23,20(24)22-25)29(26,27)19-9-7-18(28-2)8-10-19/h3-10,25H,11-15H2,1-2H3,(H,22,24)
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n/an/a 494n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-2


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128660
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenyl-propyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O5S/c1-29-19-9-11-20(12-10-19)30(27,28)22(21(25)23-26)13-16-24(17-14-22)15-5-8-18-6-3-2-4-7-18/h2-4,6-7,9-12,26H,5,8,13-17H2,1H3,(H,23,25)
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n/an/a 503n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128652
PNG
(1-Benzyl-4-(4-methoxy-benzenesulfonyl)-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H24N2O5S/c1-27-17-7-9-18(10-8-17)28(25,26)20(19(23)21-24)11-13-22(14-12-20)15-16-5-3-2-4-6-16/h2-10,24H,11-15H2,1H3,(H,21,23)
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n/an/a 229n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128655
PNG
(1-(4-Fluoro-benzyl)-4-(4-methoxy-benzenesulfonyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(F)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H23FN2O5S/c1-28-17-6-8-18(9-7-17)29(26,27)20(19(24)22-25)10-12-23(13-11-20)14-15-2-4-16(21)5-3-15/h2-9,25H,10-14H2,1H3,(H,22,24)
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n/an/a 656n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128638
PNG
(1-(4-methoxyphenethyl)-N-hydroxy-4-(4-methoxypheny...)
Show SMILES COc1ccc(CCN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-5-3-17(4-6-18)11-14-24-15-12-22(13-16-24,21(25)23-26)31(27,28)20-9-7-19(30-2)8-10-20/h3-10,26H,11-16H2,1-2H3,(H,23,25)
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n/an/a 662n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128661
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-methyl-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(C)CC1)C(=O)NO
Show InChI InChI=1S/C14H20N2O5S/c1-16-9-7-14(8-10-16,13(17)15-18)22(19,20)12-5-3-11(21-2)4-6-12/h3-6,18H,7-10H2,1-2H3,(H,15,17)
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n/an/a 44n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128651
PNG
(4-(4-(4-chlorophenoxy)phenylsulfonyl)-1-ethyl-N-hy...)
Show SMILES CCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H23ClN2O5S/c1-2-23-13-11-20(12-14-23,19(24)22-25)29(26,27)18-9-7-17(8-10-18)28-16-5-3-15(21)4-6-16/h3-10,25H,2,11-14H2,1H3,(H,22,24)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-8


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128652
PNG
(1-Benzyl-4-(4-methoxy-benzenesulfonyl)-piperidine-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C20H24N2O5S/c1-27-17-7-9-18(10-8-17)28(25,26)20(19(23)21-24)11-13-22(14-12-20)15-16-5-3-2-4-6-16/h2-10,24H,11-15H2,1H3,(H,21,23)
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n/an/a 2n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 7n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-14


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128660
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenyl-propyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O5S/c1-29-19-9-11-20(12-10-19)30(27,28)22(21(25)23-26)13-16-24(17-14-22)15-5-8-18-6-3-2-4-7-18/h2-4,6-7,9-12,26H,5,8,13-17H2,1H3,(H,23,25)
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n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128648
PNG
(1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Show SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C25H25ClN2O5S/c26-20-6-8-21(9-7-20)33-22-10-12-23(13-11-22)34(31,32)25(24(29)27-30)14-16-28(17-15-25)18-19-4-2-1-3-5-19/h1-13,30H,14-18H2,(H,27,29)
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n/an/a 1n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-13.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128637
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(4-methyl-benzyl)-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(Cc2ccc(C)cc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-16-3-5-17(6-4-16)15-23-13-11-21(12-14-23,20(24)22-25)29(26,27)19-9-7-18(28-2)8-10-19/h3-10,25H,11-15H2,1-2H3,(H,22,24)
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n/an/a 222n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50128638
PNG
(1-(4-methoxyphenethyl)-N-hydroxy-4-(4-methoxypheny...)
Show SMILES COc1ccc(CCN2CCC(CC2)(C(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-5-3-17(4-6-18)11-14-24-15-12-22(13-16-24,21(25)23-26)31(27,28)20-9-7-19(30-2)8-10-20/h3-10,26H,11-16H2,1-2H3,(H,23,25)
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n/an/a 34n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-9.


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50128644
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-(3-phenoxy-propyl)...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCCOc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C22H28N2O6S/c1-29-18-8-10-20(11-9-18)31(27,28)22(21(25)23-26)12-15-24(16-13-22)14-5-17-30-19-6-3-2-4-7-19/h2-4,6-11,26H,5,12-17H2,1H3,(H,23,25)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against matrix metalloprotease-1


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50128646
PNG
(4-(4-Methoxy-benzenesulfonyl)-1-phenethyl-piperidi...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C1(CCN(CCc2ccccc2)CC1)C(=O)NO
Show InChI InChI=1S/C21H26N2O5S/c1-28-18-7-9-19(10-8-18)29(26,27)21(20(24)22-25)12-15-23(16-13-21)14-11-17-5-3-2-4-6-17/h2-10,25H,11-16H2,1H3,(H,22,24)
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n/an/a 470n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).


J Med Chem 46: 2376-96 (2003)


Article DOI: 10.1021/jm0205550
BindingDB Entry DOI: 10.7270/Q2N0178C
More data for this
Ligand-Target Pair
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