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16 similar compounds to monomer 12074

Compile data set for download or QSAR
Wt: 412.2
BDBM12075
Purchase
Wt: 333.4
BDBM24025
Wt: 333.4
BDBM24032
Wt: 379.4
BDBM50063132
Wt: 426.3
BDBM50084281
Wt: 348.4
BDBM50084282
Wt: 347.4
BDBM50084283
Purchase
Wt: 384.2
BDBM50084285
Wt: 358.4
BDBM50084287
Wt: 430.2
BDBM50084290
Wt: 358.4
BDBM50084295
Wt: 412.2
BDBM50084299
Wt: 351.3
BDBM50084301
Wt: 361.4
BDBM50084302
Wt: 452.3
BDBM50098273
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 113 hits for monomerid = 12075,24025,24032,50063132,50084281,50084282,50084283,50084285,50084287,50084290,50084295,50084299,50084301,50084302,50098273   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Stromelysin-1


(Homo sapiens (Human))
BDBM12075
PNG
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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PubMed
4.40 -11.4n/an/an/an/an/a7.525



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM12075
PNG
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 4n/an/an/an/a7.025



Istituto di Cristallografia



Assay Description
Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...


J Med Chem 49: 923-31 (2006)


Article DOI: 10.1021/jm050787+
BindingDB Entry DOI: 10.7270/Q2348HM7
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM24025
PNG
((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m1/s1
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n/an/a 3.00E+3n/an/an/an/a7.530



Wyeth Research



Assay Description
The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...


Bioorg Med Chem Lett 16: 311-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.001
BindingDB Entry DOI: 10.7270/Q2CJ8BS1
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM24032
PNG
((2S)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a7.530



Wyeth Research



Assay Description
The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...


Bioorg Med Chem Lett 16: 311-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.001
BindingDB Entry DOI: 10.7270/Q2CJ8BS1
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-7


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against neutral endopeptidase (NEP)


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Angiotensin-converting enzyme


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Angiotensin I converting enzyme


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-3


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-1


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1)


(Homo sapiens (Human))
BDBM50063132
PNG
((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...)
Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shionogi & Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against endothelin converting enzyme (ECE)


J Med Chem 41: 640-9 (1998)


Article DOI: 10.1021/jm9707582
BindingDB Entry DOI: 10.7270/Q2HD7TS9
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 6.40E+4n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM24025
PNG
((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of aggrecanase1


Bioorg Med Chem Lett 19: 2487-91 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.056
BindingDB Entry DOI: 10.7270/Q29886WB
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50098273
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-methoxy-he...)
Show SMILES COCC#CCC(NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C19H18BrNO5S/c1-26-13-3-2-4-18(19(22)23)21-27(24,25)17-11-7-15(8-12-17)14-5-9-16(20)10-6-14/h5-12,18,21H,4,13H2,1H3,(H,22,23)
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n/an/a 17n/an/an/an/a7.4n/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against matrix metalloproteinase-2 (MMP-2) in quenched fluorescence assay at pH 7.4


J Med Chem 44: 1060-71 (2001)


Article DOI: 10.1021/jm000477l
BindingDB Entry DOI: 10.7270/Q2RN374T
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50098273
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-methoxy-he...)
Show SMILES COCC#CCC(NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C19H18BrNO5S/c1-26-13-3-2-4-18(19(22)23)21-27(24,25)17-11-7-15(8-12-17)14-5-9-16(20)10-6-14/h5-12,18,21H,4,13H2,1H3,(H,22,23)
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n/an/a 3.33E+3n/an/an/an/a7.4n/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human matrix metalloproteinase-3 (MMP-3) (at pH 7.4)


J Med Chem 44: 1060-71 (2001)


Article DOI: 10.1021/jm000477l
BindingDB Entry DOI: 10.7270/Q2RN374T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50098273
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-methoxy-he...)
Show SMILES COCC#CCC(NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C19H18BrNO5S/c1-26-13-3-2-4-18(19(22)23)21-27(24,25)17-11-7-15(8-12-17)14-5-9-16(20)10-6-14/h5-12,18,21H,4,13H2,1H3,(H,22,23)
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n/an/a 147n/an/an/an/a7.4n/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human matrix metalloproteinase-13 in quenched fluorescence assay at pH 7.4


J Med Chem 44: 1060-71 (2001)


Article DOI: 10.1021/jm000477l
BindingDB Entry DOI: 10.7270/Q2RN374T
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50098273
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-6-methoxy-he...)
Show SMILES COCC#CCC(NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C19H18BrNO5S/c1-26-13-3-2-4-18(19(22)23)21-27(24,25)17-11-7-15(8-12-17)14-5-9-16(20)10-6-14/h5-12,18,21H,4,13H2,1H3,(H,22,23)
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n/an/a 2.48E+4n/an/an/an/a7.4n/a



Procter and Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human matrix metalloproteinase-1 in quenched fluorescence assay at pH 7.4


J Med Chem 44: 1060-71 (2001)


Article DOI: 10.1021/jm000477l
BindingDB Entry DOI: 10.7270/Q2RN374T
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM24025
PNG
((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of aggrecanase-1


Bioorg Med Chem Lett 21: 6800-3 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.036
BindingDB Entry DOI: 10.7270/Q2BV7H23
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP3


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP13


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP1


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of MMP7


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Università "G. d'Annunzio"

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 expressed in mouse myeloma cells


Bioorg Med Chem 15: 791-9 (2006)


Article DOI: 10.1016/j.bmc.2006.10.047
BindingDB Entry DOI: 10.7270/Q2DR2V4T
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084282
PNG
((S)-2-(4'-amino-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C17H20N2O4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,18H2,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 105n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084283
PNG
((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H21NO4S/c1-12(2)17(18(20)21)19-24(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084281
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-4-methyl-pen...)
Show SMILES CC(C)C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C18H20BrNO4S/c1-12(2)11-17(18(21)22)20-25(23,24)16-9-5-14(6-10-16)13-3-7-15(19)8-4-13/h3-10,12,17,20H,11H2,1-2H3,(H,21,22)/t17-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084285
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-propionic ac...)
Show SMILES C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C15H14BrNO4S/c1-10(15(18)19)17-22(20,21)14-8-4-12(5-9-14)11-2-6-13(16)7-3-11/h2-10,17H,1H3,(H,18,19)/t10-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084287
PNG
((S)-2-(4'-cyano-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H18N2O4S/c1-12(2)17(18(21)22)20-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-19)4-6-14/h3-10,12,17,20H,1-2H3,(H,21,22)/t17-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084290
PNG
((S)-2-(4'-bromo-2'-fluoro-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1F)C(O)=O
Show InChI InChI=1S/C17H17BrFNO4S/c1-10(2)16(17(21)22)20-25(23,24)13-6-3-11(4-7-13)14-8-5-12(18)9-15(14)19/h3-10,16,20H,1-2H3,(H,21,22)/t16-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50084282
PNG
((S)-2-(4'-amino-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C17H20N2O4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,18H2,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084287
PNG
((S)-2-(4'-cyano-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H18N2O4S/c1-12(2)17(18(21)22)20-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-19)4-6-14/h3-10,12,17,20H,1-2H3,(H,21,22)/t17-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084295
PNG
(2-(4'-Cyano-biphenyl-4-sulfonylamino)-3-methyl-but...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H18N2O4S/c1-12(2)17(18(21)22)20-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-19)4-6-14/h3-10,12,17,20H,1-2H3,(H,21,22)/t17-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084283
PNG
((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H21NO4S/c1-12(2)17(18(20)21)19-24(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m0/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084282
PNG
((S)-2-(4'-amino-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C17H20N2O4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,18H2,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-9 (MMP-9)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084295
PNG
(2-(4'-Cyano-biphenyl-4-sulfonylamino)-3-methyl-but...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H18N2O4S/c1-12(2)17(18(21)22)20-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-19)4-6-14/h3-10,12,17,20H,1-2H3,(H,21,22)/t17-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084299
PNG
((S)-2-(3'-bromo-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(Br)c1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-8-6-12(7-9-15)13-4-3-5-14(18)10-13/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-9 (MMP-9)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084287
PNG
((S)-2-(4'-cyano-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H18N2O4S/c1-12(2)17(18(21)22)20-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-19)4-6-14/h3-10,12,17,20H,1-2H3,(H,21,22)/t17-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084299
PNG
((S)-2-(3'-bromo-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(Br)c1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-8-6-12(7-9-15)13-4-3-5-14(18)10-13/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 535n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM12075
PNG
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50084285
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-propionic ac...)
Show SMILES C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C15H14BrNO4S/c1-10(15(18)19)17-22(20,21)14-8-4-12(5-9-14)11-2-6-13(16)7-3-11/h2-10,17H,1H3,(H,18,19)/t10-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084282
PNG
((S)-2-(4'-amino-biphenyl-4-sulfonylamino)-3-methyl...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C17H20N2O4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,18H2,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084283
PNG
((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H21NO4S/c1-12(2)17(18(20)21)19-24(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084285
PNG
(2-(4'-Bromo-biphenyl-4-sulfonylamino)-propionic ac...)
Show SMILES C[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C15H14BrNO4S/c1-10(15(18)19)17-22(20,21)14-8-4-12(5-9-14)11-2-6-13(16)7-3-11/h2-10,17H,1H3,(H,18,19)/t10-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-7 (MMP-7)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084302
PNG
((S)-2-(4'-formyl-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C=O)cc1)C(O)=O
Show InChI InChI=1S/C18H19NO5S/c1-12(2)17(18(21)22)19-25(23,24)16-9-7-15(8-10-16)14-5-3-13(11-20)4-6-14/h3-12,17,19H,1-2H3,(H,21,22)/t17-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM24032
PNG
((2S)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H19NO4S/c1-12(2)16(17(19)20)18-23(21,22)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12,16,18H,1-2H3,(H,19,20)/t16-/m0/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50084290
PNG
((S)-2-(4'-bromo-2'-fluoro-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1F)C(O)=O
Show InChI InChI=1S/C17H17BrFNO4S/c1-10(2)16(17(21)22)20-25(23,24)13-6-3-11(4-7-13)14-8-5-12(18)9-15(14)19/h3-10,16,20H,1-2H3,(H,21,22)/t16-/m0/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084301
PNG
((S)-2-(4'-fluoro-biphenyl-4-sulfonylamino)-3-methy...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C17H18FNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1
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n/an/a 6.40E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-9 (MMP-9)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50084283
PNG
((S)-3-methyl-2-(4'-methyl-biphenyl-4-sulfonylamino...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H21NO4S/c1-12(2)17(18(20)21)19-24(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
In vitro inhibition of matrix metalloprotease-2 (MMP-2)


J Med Chem 43: 156-66 (2000)


Article DOI: 10.1021/jm9903141
BindingDB Entry DOI: 10.7270/Q2T154BF
More data for this
Ligand-Target Pair
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