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112 similar compounds to monomer 121129

Compile data set for download or QSAR
Wt: 444.9
BDBM121033
Wt: 480.9
BDBM121038
Wt: 489.0
BDBM121039
Wt: 475.0
BDBM121040
Wt: 462.9
BDBM121041
Wt: 444.9
BDBM121042
Wt: 500.0
BDBM121045
Wt: 515.0
BDBM121049
Wt: 501.0
BDBM121050
Wt: 517.0
BDBM121052
Wt: 485.0
BDBM121053
Wt: 517.0
BDBM121054
Wt: 472.0
BDBM121055
Wt: 486.0
BDBM121056
Wt: 491.4
BDBM121057
Displayed 1 to 15 (of 112 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 121033,121038,121039,121040,121041,121042,121045,121049,121050,121052,121053,121054,121055,121056,121057   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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US Patent
0.720 -13.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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US Patent
1.35 -12.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
1.40 -12.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121041
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((4- fluoro)benzyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccc(F)cc1
Show InChI InChI=1S/C25H32ClFN2O3/c1-17(2)15-29(16-20-11-22(26)24-23(12-20)31-9-4-10-32-24)25(30)18(3)13-28-14-19-5-7-21(27)8-6-19/h5-8,11-12,17-18,28H,4,9-10,13-16H2,1-3H3
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US Patent
1.62 -12.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121053
PNG
(US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(C)c2C)C1
Show InChI InChI=1S/C28H37ClN2O3/c1-19(2)15-31(16-22-13-25(29)27-26(14-22)33-11-6-12-34-27)28(32)24-9-10-30(18-24)17-23-8-5-7-20(3)21(23)4/h5,7-8,13-14,19,24H,6,9-12,15-18H2,1-4H3
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US Patent
1.89 -12.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
4.92 -11.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121050
PNG
(US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3OCOc23)C1
Show InChI InChI=1S/C27H33ClN2O5/c1-18(2)13-30(14-19-11-22(28)26-24(12-19)32-9-4-10-33-26)27(31)21-7-8-29(16-21)15-20-5-3-6-23-25(20)35-17-34-23/h3,5-6,11-12,18,21H,4,7-10,13-17H2,1-2H3
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5.16 -11.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121049
PNG
(US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxi...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3OCCOc23)C1
Show InChI InChI=1S/C28H35ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-25(14-20)33-9-4-10-35-27)28(32)22-7-8-30(18-22)17-21-5-3-6-24-26(21)36-12-11-34-24/h3,5-6,13-14,19,22H,4,7-12,15-18H2,1-2H3
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5.68 -11.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121049
PNG
(US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxi...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3OCCOc23)C1
Show InChI InChI=1S/C28H35ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-25(14-20)33-9-4-10-35-27)28(32)22-7-8-30(18-22)17-21-5-3-6-24-26(21)36-12-11-34-24/h3,5-6,13-14,19,22H,4,7-12,15-18H2,1-2H3
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US Patent
6.88 -11.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121039
PNG
(US8722896, (+/-)-2-Methyl-3-((2- ethoxy)benzylamin...)
Show SMILES CCOc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H37ClN2O4/c1-5-32-24-10-7-6-9-22(24)16-29-15-20(4)27(31)30(17-19(2)3)18-21-13-23(28)26-25(14-21)33-11-8-12-34-26/h6-7,9-10,13-14,19-20,29H,5,8,11-12,15-18H2,1-4H3
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US Patent
7.18 -11.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121054
PNG
(US8722896, (-)-(3R)-1-(2,5- Dimethoxybenzyl)-N-(9-...)
Show SMILES COc1ccc(OC)c(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C28H37ClN2O5/c1-19(2)15-31(16-20-12-24(29)27-26(13-20)35-10-5-11-36-27)28(32)21-8-9-30(17-21)18-22-14-23(33-3)6-7-25(22)34-4/h6-7,12-14,19,21H,5,8-11,15-18H2,1-4H3
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US Patent
7.32 -11.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
8.30 -11.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121038
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((2,6- difluoro)ben...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1c(F)cccc1F
Show InChI InChI=1S/C25H31ClF2N2O3/c1-16(2)14-30(15-18-10-20(26)24-23(11-18)32-8-5-9-33-24)25(31)17(3)12-29-13-19-21(27)6-4-7-22(19)28/h4,6-7,10-11,16-17,29H,5,8-9,12-15H2,1-3H3
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US Patent
8.58 -11.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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US Patent
8.76 -11.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121038
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((2,6- difluoro)ben...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1c(F)cccc1F
Show InChI InChI=1S/C25H31ClF2N2O3/c1-16(2)14-30(15-18-10-20(26)24-23(11-18)32-8-5-9-33-24)25(31)17(3)12-29-13-19-21(27)6-4-7-22(19)28/h4,6-7,10-11,16-17,29H,5,8-9,12-15H2,1-3H3
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US Patent
9.84 -11.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121053
PNG
(US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(C)c2C)C1
Show InChI InChI=1S/C28H37ClN2O3/c1-19(2)15-31(16-22-13-25(29)27-26(14-22)33-11-6-12-34-27)28(32)24-9-10-30(18-24)17-23-8-5-7-20(3)21(23)4/h5,7-8,13-14,19,24H,6,9-12,15-18H2,1-4H3
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11.6 -11.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121049
PNG
(US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxi...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3OCCOc23)C1
Show InChI InChI=1S/C28H35ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-25(14-20)33-9-4-10-35-27)28(32)22-7-8-30(18-22)17-21-5-3-6-24-26(21)36-12-11-34-24/h3,5-6,13-14,19,22H,4,7-12,15-18H2,1-2H3
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12.2 -11.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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25.2 -10.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121055
PNG
(US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2N)C1
Show InChI InChI=1S/C26H34ClN3O3/c1-18(2)14-30(15-19-12-22(27)25-24(13-19)32-10-5-11-33-25)26(31)21-8-9-29(17-21)16-20-6-3-4-7-23(20)28/h3-4,6-7,12-13,18,21H,5,8-11,14-17,28H2,1-2H3
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31.5 -10.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
32.4 -10.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121045
PNG
(US8722896, (-)-(3R)-1-((3- Dimethylamino)benzyl)-N...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(c2)N(C)C)C1
Show InChI InChI=1S/C28H38ClN3O3/c1-20(2)16-32(18-22-14-25(29)27-26(15-22)34-11-6-12-35-27)28(33)23-9-10-31(19-23)17-21-7-5-8-24(13-21)30(3)4/h5,7-8,13-15,20,23H,6,9-12,16-19H2,1-4H3
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US Patent
38.4 -10.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121055
PNG
(US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2N)C1
Show InChI InChI=1S/C26H34ClN3O3/c1-18(2)14-30(15-19-12-22(27)25-24(13-19)32-10-5-11-33-25)26(31)21-8-9-29(17-21)16-20-6-3-4-7-23(20)28/h3-4,6-7,12-13,18,21H,5,8-11,14-17,28H2,1-2H3
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US Patent
38.7 -10.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121057
PNG
(US8722896, (-)-(3R)-1-(2-Chlorobenzyl)-N- (9-chlor...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2ccccc2Cl)C1
Show InChI InChI=1S/C26H32Cl2N2O3/c1-18(2)14-30(15-19-12-23(28)25-24(13-19)32-10-5-11-33-25)26(31)21-8-9-29(17-21)16-20-6-3-4-7-22(20)27/h3-4,6-7,12-13,18,21H,5,8-11,14-17H2,1-2H3
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US Patent
38.9 -10.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121052
PNG
(US8722896, (-)-(3R)-1-(2,3- Dimethoxybenzyl)-N-(9-...)
Show SMILES COc1cccc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1OC
Show InChI InChI=1S/C28H37ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-25(14-20)35-11-6-12-36-27)28(32)22-9-10-30(18-22)17-21-7-5-8-24(33-3)26(21)34-4/h5,7-8,13-14,19,22H,6,9-12,15-18H2,1-4H3
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US Patent
43.4 -10.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121054
PNG
(US8722896, (-)-(3R)-1-(2,5- Dimethoxybenzyl)-N-(9-...)
Show SMILES COc1ccc(OC)c(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1S/C28H37ClN2O5/c1-19(2)15-31(16-20-12-24(29)27-26(13-20)35-10-5-11-36-27)28(32)21-8-9-30(17-21)18-22-14-23(33-3)6-7-25(22)34-4/h6-7,12-14,19,21H,5,8-11,15-18H2,1-4H3
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US Patent
47.8 -10.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121039
PNG
(US8722896, (+/-)-2-Methyl-3-((2- ethoxy)benzylamin...)
Show SMILES CCOc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1S/C27H37ClN2O4/c1-5-32-24-10-7-6-9-22(24)16-29-15-20(4)27(31)30(17-19(2)3)18-21-13-23(28)26-25(14-21)33-11-8-12-34-26/h6-7,9-10,13-14,19-20,29H,5,8,11-12,15-18H2,1-4H3
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US Patent
55.2 -10.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121050
PNG
(US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3OCOc23)C1
Show InChI InChI=1S/C27H33ClN2O5/c1-18(2)13-30(14-19-11-22(28)26-24(12-19)32-9-4-10-33-26)27(31)21-7-8-29(16-21)15-20-5-3-6-23-25(20)35-17-34-23/h3,5-6,11-12,18,21H,4,7-10,13-17H2,1-2H3
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US Patent
61.2 -10.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121056
PNG
(US8722896, (-)-(3R)-1-(2-Aminobenzyl)-N- (9-chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2ccccc2N)C1
Show InChI InChI=1S/C27H36ClN3O3/c1-19(2)15-31(16-20-13-23(28)26-25(14-20)33-11-6-12-34-26)27(32)22-8-5-10-30(18-22)17-21-7-3-4-9-24(21)29/h3-4,7,9,13-14,19,22H,5-6,8,10-12,15-18,29H2,1-2H3
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US Patent
65.1 -10.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121045
PNG
(US8722896, (-)-(3R)-1-((3- Dimethylamino)benzyl)-N...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(c2)N(C)C)C1
Show InChI InChI=1S/C28H38ClN3O3/c1-20(2)16-32(18-22-14-25(29)27-26(15-22)34-11-6-12-35-27)28(33)23-9-10-31(19-23)17-21-7-5-8-24(13-21)30(3)4/h5,7-8,13-15,20,23H,6,9-12,16-19H2,1-4H3
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US Patent
71.8 -10.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
73.2 -10.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
85.8 -10.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121038
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((2,6- difluoro)ben...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1c(F)cccc1F
Show InChI InChI=1S/C25H31ClF2N2O3/c1-16(2)14-30(15-18-10-20(26)24-23(11-18)32-8-5-9-33-24)25(31)17(3)12-29-13-19-21(27)6-4-7-22(19)28/h4,6-7,10-11,16-17,29H,5,8-9,12-15H2,1-3H3
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US Patent
121 -9.81n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121052
PNG
(US8722896, (-)-(3R)-1-(2,3- Dimethoxybenzyl)-N-(9-...)
Show SMILES COc1cccc(CN2CCC(C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1OC
Show InChI InChI=1S/C28H37ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-25(14-20)35-11-6-12-36-27)28(32)22-9-10-30(18-22)17-21-7-5-8-24(33-3)26(21)34-4/h5,7-8,13-14,19,22H,6,9-12,15-18H2,1-4H3
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US Patent
173 -9.59n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
178 -9.57n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121033
PNG
(US8722896, 3-(Benzyl(methyl)amino)-N-(9- chloro-3,...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)CCN(C)Cc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-19(2)16-28(24(29)10-11-27(3)17-20-8-5-4-6-9-20)18-21-14-22(26)25-23(15-21)30-12-7-13-31-25/h4-6,8-9,14-15,19H,7,10-13,16-18H2,1-3H3
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US Patent
272 -9.31n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 1 (PRK1)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1S/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
1.36E+3 -8.32n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair