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14 similar compounds to monomer 121413

Compile data set for download or QSAR
Wt: 293.3
BDBM121404
Wt: 313.7
BDBM121405
Wt: 311.3
BDBM121409
Wt: 293.3
BDBM121410
Wt: 293.3
BDBM121411
Wt: 313.7
BDBM121412
Wt: 309.3
BDBM121414
Wt: 309.3
BDBM121415
Wt: 297.2
BDBM121416
Wt: 297.2
BDBM121417
Wt: 331.7
BDBM121420
Wt: 347.2
BDBM121399
Wt: 297.2
BDBM121401
Wt: 279.2
BDBM121402

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 121404,121405,121409,121410,121411,121412,121414,121415,121416,121417,121420,121399,121401,121402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121399
PNG
(US8722709, 2)
Show SMILES NC(=O)Nc1cc(ccn1)-c1cc(nn1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)13-9-12(24(23-13)11-4-2-1-3-5-11)10-6-7-21-14(8-10)22-15(20)25/h1-9H,(H3,20,21,22,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 130n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121401
PNG
(US8722709, 4)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FN5O/c16-11-1-3-12(4-2-11)21-13(6-8-19-21)10-5-7-18-14(9-10)20-15(17)22/h1-9H,(H3,17,18,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

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US Patent
n/an/a 62n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121402
PNG
(US8722709, 5)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1ccccc1
Show InChI InChI=1S/C15H13N5O/c16-15(21)19-14-10-11(6-8-17-14)13-7-9-18-20(13)12-4-2-1-3-5-12/h1-10H,(H3,16,17,19,21)
PDB
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US Patent
n/an/a 670n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121404
PNG
(US8722709, 7)
Show SMILES Cc1ccccc1-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H15N5O/c1-11-4-2-3-5-13(11)21-14(7-9-19-21)12-6-8-18-15(10-12)20-16(17)22/h2-10H,1H3,(H3,17,18,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 280n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121405
PNG
(US8722709, 8)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1ccccc1Cl
Show InChI InChI=1S/C15H12ClN5O/c16-11-3-1-2-4-13(11)21-12(6-8-19-21)10-5-7-18-14(9-10)20-15(17)22/h1-9H,(H3,17,18,20,22)
PDB
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KEGG

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US Patent
n/an/a 790n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121409
PNG
(US8722709, 12)
Show SMILES Cc1cc(F)ccc1-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H14FN5O/c1-10-8-12(17)2-3-13(10)22-14(5-7-20-22)11-4-6-19-15(9-11)21-16(18)23/h2-9H,1H3,(H3,18,19,21,23)
PDB
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KEGG

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US Patent
n/an/a 38n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121420
PNG
(US8722709, 23)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1ccc(F)cc1Cl
Show InChI InChI=1S/C15H11ClFN5O/c16-11-8-10(17)1-2-13(11)22-12(4-6-20-22)9-3-5-19-14(7-9)21-15(18)23/h1-8H,(H3,18,19,21,23)
PDB
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US Patent
n/an/a 190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121411
PNG
(US8722709, 14)
Show SMILES Cc1ccc(cc1)-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H15N5O/c1-11-2-4-13(5-3-11)21-14(7-9-19-21)12-6-8-18-15(10-12)20-16(17)22/h2-10H,1H3,(H3,17,18,20,22)
PDB
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KEGG

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US Patent
n/an/a 14n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121412
PNG
(US8722709, 15)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClN5O/c16-11-2-1-3-12(9-11)21-13(5-7-19-21)10-4-6-18-14(8-10)20-15(17)22/h1-9H,(H3,17,18,20,22)
PDB
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KEGG

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UniChem

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US Patent
n/an/a 190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121414
PNG
(US8722709, 17)
Show SMILES COc1cccc(c1)-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H15N5O2/c1-23-13-4-2-3-12(10-13)21-14(6-8-19-21)11-5-7-18-15(9-11)20-16(17)22/h2-10H,1H3,(H3,17,18,20,22)
PDB
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US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121415
PNG
(US8722709, 18)
Show SMILES COc1ccc(cc1)-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H15N5O2/c1-23-13-4-2-12(3-5-13)21-14(7-9-19-21)11-6-8-18-15(10-11)20-16(17)22/h2-10H,1H3,(H3,17,18,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121416
PNG
(US8722709, 19)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1cccc(F)c1
Show InChI InChI=1S/C15H12FN5O/c16-11-2-1-3-12(9-11)21-13(5-7-19-21)10-4-6-18-14(8-10)20-15(17)22/h1-9H,(H3,17,18,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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GoogleScholar
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UniChem

Similars

US Patent
n/an/a 310n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121417
PNG
(US8722709, 20)
Show SMILES NC(=O)Nc1cc(ccn1)-c1ccnn1-c1ccccc1F
Show InChI InChI=1S/C15H12FN5O/c16-11-3-1-2-4-13(11)21-12(6-8-19-21)10-5-7-18-14(9-10)20-15(17)22/h1-9H,(H3,17,18,20,22)
PDB
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KEGG

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UniChem

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US Patent
n/an/a 300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair
Mineralocorticoid receptor


(Homo sapiens (Human))
BDBM121410
PNG
(US8722709, 13)
Show SMILES Cc1cccc(c1)-n1nccc1-c1ccnc(NC(N)=O)c1
Show InChI InChI=1S/C16H15N5O/c1-11-3-2-4-13(9-11)21-14(6-8-19-21)12-5-7-18-15(10-12)20-16(17)22/h2-10H,1H3,(H3,17,18,20,22)
PDB
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KEGG

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US Patent
n/an/a 160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The MR competitive binding assay is based on the binding and displacement of a TAMRA-labeled Dexamethasone probe with fluorescence polarization (FP) ...


US Patent US8722709 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SJ4
More data for this
Ligand-Target Pair