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8 similar compounds to monomer 12169

Compile data set for download or QSAR
Wt: 313.3
BDBM12165
Wt: 381.3
BDBM12168
Wt: 301.3
BDBM12172
Wt: 338.4
BDBM12178
Wt: 341.4
BDBM50326394
Wt: 440.5
BDBM50326396
Wt: 384.4
BDBM50326397
Wt: 340.4
BDBM50375025

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 12165,12168,12172,12178,50326394,50326396,50326397,50375025   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50326397
PNG
((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C20H24N4O4/c21-18(26)16-6-3-7-24(16)20(28)15-8-14(19(27)22-15)9-17(25)23-10-12-4-1-2-5-13(12)11-23/h1-2,4-5,14-16H,3,6-11H2,(H2,21,26)(H,22,27)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP4 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12172
PNG
((3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrol...)
Show SMILES O=C(NCc1ccccc1)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H23N3O2/c21-16(19-11-13-6-2-1-3-7-13)14-10-15(18-12-14)17(22)20-8-4-5-9-20/h1-3,6-7,14-15,18H,4-5,8-12H2,(H,19,21)/t14-,15-/m0/s1
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n/an/a 1.96E+3n/an/an/an/a8.037



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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12178
PNG
((2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylca...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H22N4O2/c20-9-16-6-3-7-23(16)19(25)17-8-15(10-21-17)18(24)22-11-13-4-1-2-5-14(13)12-22/h1-2,4-5,15-17,21H,3,6-8,10-12H2/t15-,16-,17-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12168
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES FC(F)(F)c1ccc2CN(Cc2c1)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H22F3N3O2/c20-19(21,22)15-4-3-12-10-25(11-14(12)7-15)17(26)13-8-16(23-9-13)18(27)24-5-1-2-6-24/h3-4,7,13,16,23H,1-2,5-6,8-11H2/t13-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12172
PNG
((3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrol...)
Show SMILES O=C(NCc1ccccc1)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H23N3O2/c21-16(19-11-13-6-2-1-3-7-13)14-10-15(18-12-14)17(22)20-8-4-5-9-20/h1-3,6-7,14-15,18H,4-5,8-12H2,(H,19,21)/t14-,15-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12178
PNG
((2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylca...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H22N4O2/c20-9-16-6-3-7-23(16)19(25)17-8-15(10-21-17)18(24)22-11-13-4-1-2-5-14(13)12-22/h1-2,4-5,15-17,21H,3,6-8,10-12H2/t15-,16-,17-/m0/s1
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n/an/a 2.73E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12168
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES FC(F)(F)c1ccc2CN(Cc2c1)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H22F3N3O2/c20-19(21,22)15-4-3-12-10-25(11-14(12)7-15)17(26)13-8-16(23-9-13)18(27)24-5-1-2-6-24/h3-4,7,13,16,23H,1-2,5-6,8-11H2/t13-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12172
PNG
((3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrol...)
Show SMILES O=C(NCc1ccccc1)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H23N3O2/c21-16(19-11-13-6-2-1-3-7-13)14-10-15(18-12-14)17(22)20-8-4-5-9-20/h1-3,6-7,14-15,18H,4-5,8-12H2,(H,19,21)/t14-,15-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12178
PNG
((2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylca...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H22N4O2/c20-9-16-6-3-7-23(16)19(25)17-8-15(10-21-17)18(24)22-11-13-4-1-2-5-14(13)12-22/h1-2,4-5,15-17,21H,3,6-8,10-12H2/t15-,16-,17-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12168
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES FC(F)(F)c1ccc2CN(Cc2c1)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H22F3N3O2/c20-19(21,22)15-4-3-12-10-25(11-14(12)7-15)17(26)13-8-16(23-9-13)18(27)24-5-1-2-6-24/h3-4,7,13,16,23H,1-2,5-6,8-11H2/t13-,16-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12172
PNG
((3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrol...)
Show SMILES O=C(NCc1ccccc1)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H23N3O2/c21-16(19-11-13-6-2-1-3-7-13)14-10-15(18-12-14)17(22)20-8-4-5-9-20/h1-3,6-7,14-15,18H,4-5,8-12H2,(H,19,21)/t14-,15-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12178
PNG
((2S)-1-{[(2S,4S)-4-(2,3-dihydro-1H-isoindol-2-ylca...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCC[C@H]1C#N)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H22N4O2/c20-9-16-6-3-7-23(16)19(25)17-8-15(10-21-17)18(24)22-11-13-4-1-2-5-14(13)12-22/h1-2,4-5,15-17,21H,3,6-8,10-12H2/t15-,16-,17-/m0/s1
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Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50375025
PNG
(CHEMBL438547)
Show SMILES CCN(CC#N)C(=O)[C@@H]1C[C@@H]([C@H](C)N1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H24N4O2/c1-3-22(9-8-20)19(25)17-10-16(13(2)21-17)18(24)23-11-14-6-4-5-7-15(14)12-23/h4-7,13,16-17,21H,3,9-12H2,1-2H3/t13-,16-,17-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DPP4


Bioorg Med Chem 16: 190-208 (2008)


Article DOI: 10.1016/j.bmc.2007.10.005
BindingDB Entry DOI: 10.7270/Q20C4WN6
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50326394
PNG
((3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl...)
Show SMILES O=C(C[C@@H]1C[C@H](NC1=O)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c23-17(22-11-13-5-1-2-6-14(13)12-22)10-15-9-16(20-18(15)24)19(25)21-7-3-4-8-21/h1-2,5-6,15-16H,3-4,7-12H2,(H,20,24)/t15-,16-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAP expressed in Hi5 insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50326396
PNG
((2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)26-22(31)19-9-6-10-28(19)23(32)18-11-17(21(30)25-18)12-20(29)27-13-15-7-4-5-8-16(15)14-27/h4-5,7-8,17-19H,6,9-14H2,1-3H3,(H,25,30)(H,26,31)/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAP expressed in Hi5 insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50326397
PNG
((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C20H24N4O4/c21-18(26)16-6-3-7-24(16)20(28)15-8-14(19(27)22-15)9-17(25)23-10-12-4-1-2-5-13(12)11-23/h1-2,4-5,14-16H,3,6-11H2,(H2,21,26)(H,22,27)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAP expressed in Hi5 insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50326394
PNG
((3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl...)
Show SMILES O=C(C[C@@H]1C[C@H](NC1=O)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c23-17(22-11-13-5-1-2-6-14(13)12-22)10-15-9-16(20-18(15)24)19(25)21-7-3-4-8-21/h1-2,5-6,15-16H,3-4,7-12H2,(H,20,24)/t15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP8 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50326396
PNG
((2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)26-22(31)19-9-6-10-28(19)23(32)18-11-17(21(30)25-18)12-20(29)27-13-15-7-4-5-8-16(15)14-27/h4-5,7-8,17-19H,6,9-14H2,1-3H3,(H,25,30)(H,26,31)/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP8 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50326397
PNG
((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C20H24N4O4/c21-18(26)16-6-3-7-24(16)20(28)15-8-14(19(27)22-15)9-17(25)23-10-12-4-1-2-5-13(12)11-23/h1-2,4-5,14-16H,3,6-11H2,(H2,21,26)(H,22,27)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP8 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50326394
PNG
((3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl...)
Show SMILES O=C(C[C@@H]1C[C@H](NC1=O)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c23-17(22-11-13-5-1-2-6-14(13)12-22)10-15-9-16(20-18(15)24)19(25)21-7-3-4-8-21/h1-2,5-6,15-16H,3-4,7-12H2,(H,20,24)/t15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP9 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50326396
PNG
((2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)26-22(31)19-9-6-10-28(19)23(32)18-11-17(21(30)25-18)12-20(29)27-13-15-7-4-5-8-16(15)14-27/h4-5,7-8,17-19H,6,9-14H2,1-3H3,(H,25,30)(H,26,31)/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP9 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM50326397
PNG
((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C20H24N4O4/c21-18(26)16-6-3-7-24(16)20(28)15-8-14(19(27)22-15)9-17(25)23-10-12-4-1-2-5-13(12)11-23/h1-2,4-5,14-16H,3,6-11H2,(H2,21,26)(H,22,27)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP9 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50326394
PNG
((3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl...)
Show SMILES O=C(C[C@@H]1C[C@H](NC1=O)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c23-17(22-11-13-5-1-2-6-14(13)12-22)10-15-9-16(20-18(15)24)19(25)21-7-3-4-8-21/h1-2,5-6,15-16H,3-4,7-12H2,(H,20,24)/t15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP2 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50326396
PNG
((2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)26-22(31)19-9-6-10-28(19)23(32)18-11-17(21(30)25-18)12-20(29)27-13-15-7-4-5-8-16(15)14-27/h4-5,7-8,17-19H,6,9-14H2,1-3H3,(H,25,30)(H,26,31)/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP2 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50326397
PNG
((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C20H24N4O4/c21-18(26)16-6-3-7-24(16)20(28)15-8-14(19(27)22-15)9-17(25)23-10-12-4-1-2-5-13(12)11-23/h1-2,4-5,14-16H,3,6-11H2,(H2,21,26)(H,22,27)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP2 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50326394
PNG
((3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl...)
Show SMILES O=C(C[C@@H]1C[C@H](NC1=O)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C19H23N3O3/c23-17(22-11-13-5-1-2-6-14(13)12-22)10-15-9-16(20-18(15)24)19(25)21-7-3-4-8-21/h1-2,5-6,15-16H,3-4,7-12H2,(H,20,24)/t15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP4 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50326396
PNG
((2S)-1-{(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-...)
Show SMILES CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1C[C@@H](CC(=O)N2Cc3ccccc3C2)C(=O)N1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)26-22(31)19-9-6-10-28(19)23(32)18-11-17(21(30)25-18)12-20(29)27-13-15-7-4-5-8-16(15)14-27/h4-5,7-8,17-19H,6,9-14H2,1-3H3,(H,25,30)(H,26,31)/t17-,18-,19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged DPP4 expressed in insect cells


J Med Chem 53: 6572-83 (2010)


Article DOI: 10.1021/jm1002556
BindingDB Entry DOI: 10.7270/Q23F4QM9
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12168
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES FC(F)(F)c1ccc2CN(Cc2c1)C(=O)[C@@H]1CN[C@@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H22F3N3O2/c20-19(21,22)15-4-3-12-10-25(11-14(12)7-15)17(26)13-8-16(23-9-13)18(27)24-5-1-2-6-24/h3-4,7,13,16,23H,1-2,5-6,8-11H2/t13-,16-/m0/s1
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n/an/a 73n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair