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3 similar compounds to monomer 12176

Compile data set for download or QSAR
Wt: 313.3
BDBM12165
Wt: 331.3
BDBM12175
Wt: 349.3
BDBM12177

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 12165,12175,12177   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a 109n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12175
PNG
(2-{[(3S,5S)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbo...)
Show SMILES F[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H22FN3O2/c19-15-5-6-21(11-15)18(24)16-7-14(8-20-16)17(23)22-9-12-3-1-2-4-13(12)10-22/h1-4,14-16,20H,5-11H2/t14-,15-,16-/m0/s1
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n/an/a 245n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12177
PNG
(2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...)
Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1
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PubMed
n/an/a 129n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12175
PNG
(2-{[(3S,5S)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbo...)
Show SMILES F[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H22FN3O2/c19-15-5-6-21(11-15)18(24)16-7-14(8-20-16)17(23)22-9-12-3-1-2-4-13(12)10-22/h1-4,14-16,20H,5-11H2/t14-,15-,16-/m0/s1
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PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12177
PNG
(2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...)
Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1
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Article
PubMed
n/an/a 1.95E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12175
PNG
(2-{[(3S,5S)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbo...)
Show SMILES F[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H22FN3O2/c19-15-5-6-21(11-15)18(24)16-7-14(8-20-16)17(23)22-9-12-3-1-2-4-13(12)10-22/h1-4,14-16,20H,5-11H2/t14-,15-,16-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12177
PNG
(2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...)
Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1
PDB
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Article
PubMed
n/an/a 1.93E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
PDB
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UniChem

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Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12175
PNG
(2-{[(3S,5S)-5-{[(3S)-3-fluoropyrrolidin-1-yl]carbo...)
Show SMILES F[C@H]1CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H22FN3O2/c19-15-5-6-21(11-15)18(24)16-7-14(8-20-16)17(23)22-9-12-3-1-2-4-13(12)10-22/h1-4,14-16,20H,5-11H2/t14-,15-,16-/m0/s1
PDB
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UniChem

Similars

Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12177
PNG
(2-{[(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbon...)
Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1C[C@@H](CN1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H21F2N3O2/c19-18(20)5-6-22(11-18)17(25)15-7-14(8-21-15)16(24)23-9-12-3-1-2-4-13(12)10-23/h1-4,14-15,21H,5-11H2/t14-,15-/m0/s1
PDB

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Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair