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4 similar compounds to monomer 50243318

Compile data set for download or QSAR
Wt: 313.3
BDBM12165
Wt: 231.2
BDBM50243316
Wt: 321.4
BDBM50243317
Wt: 321.4
BDBM50243242

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 12165,50243316,50243317,50243242   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a 109n/an/an/an/a8.037



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (Human))
BDBM50243242
PNG
(((2S,4S)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19-/m0/s1
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n/an/a 1.31E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Fibroblast Activation Protein (FAP)


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243317
PNG
(((2S,4R)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19+/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50243242
PNG
(((2S,4S)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50243317
PNG
(((2S,4R)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50243242
PNG
(((2S,4S)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19-/m0/s1
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n/an/a>2.50E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243317
PNG
(((2S,4R)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19+/m1/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM50243242
PNG
(((2S,4S)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP8 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (Human))
BDBM50243317
PNG
(((2S,4R)-4-(benzylamino)pyrrolidin-2-yl)(isoindoli...)
Show SMILES O=C([C@@H]1C[C@H](CN1)NCc1ccccc1)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H23N3O/c24-20(23-13-16-8-4-5-9-17(16)14-23)19-10-18(12-22-19)21-11-15-6-2-1-3-7-15/h1-9,18-19,21-22H,10-14H2/t18-,19+/m1/s1
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n/an/a 2.98E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (Human))
BDBM50243316
PNG
(((2S,4R)-4-aminopyrrolidin-2-yl)(isoindolin-2-yl)m...)
Show SMILES N[C@H]1CN[C@@H](C1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C13H17N3O/c14-11-5-12(15-6-11)13(17)16-7-9-3-1-2-4-10(9)8-16/h1-4,11-12,15H,5-8,14H2/t11-,12+/m1/s1
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n/an/a 6.78E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP9 (unknown origin)


Bioorg Med Chem Lett 18: 4159-62 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.079
BindingDB Entry DOI: 10.7270/Q2KS6RC4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (Human))
BDBM12165
PNG
(2-{[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-...)
Show SMILES O=C([C@@H]1CN[C@@H](C1)C(=O)N1CCCC1)N1Cc2ccccc2C1
Show InChI InChI=1S/C18H23N3O2/c22-17(21-11-13-5-1-2-6-14(13)12-21)15-9-16(19-10-15)18(23)20-7-3-4-8-20/h1-2,5-6,15-16,19H,3-4,7-12H2/t15-,16-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



National Health Research Institutes



Assay Description
The enzyme activity resulted in the liberation of free pNA at 405 nm. Reaction progress was monitored using a Molecular Devices SpectraMax Plus micro...


Bioorg Med Chem Lett 16: 3268-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.037
BindingDB Entry DOI: 10.7270/Q22805V8
More data for this
Ligand-Target Pair