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21 similar compounds to monomer 123038

Wt: 421.3
BDBM123010
Wt: 339.2
BDBM123016
Wt: 423.2
BDBM123022
Wt: 423.2
BDBM123023
Wt: 369.3
BDBM123028
Wt: 353.3
BDBM123029
Wt: 353.3
BDBM123030
Wt: 339.2
BDBM123031
Wt: 373.7
BDBM123032
Wt: 373.7
BDBM123033
Wt: 373.7
BDBM123034
Wt: 407.2
BDBM123035
Wt: 407.2
BDBM123036
Wt: 423.2
BDBM123037
Wt: 408.1
BDBM123039
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 123010,123016,123022,123023,123028,123029,123030,123031,123032,123033,123034,123035,123036,123037,123039   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 protease


(Human immunodeficiency virus)
BDBM123010
PNG
(US8742138, 38 | US8742158, EX 22)
Show SMILES C[C@H](NC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H14F3NO6/c1-9(17(26)27)24-16(25)15-14-12(6-3-7-13(14)18(28)30-19(15)29)10-4-2-5-11(8-10)20(21,22)23/h2-9,28H,1H3,(H,24,25)(H,26,27)/t9-/m0/s1
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US Patent
n/an/a 1.35n/an/an/an/an/an/a



TaiMed Biologies, Inc.

US Patent


Assay Description
This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...


US Patent US8742158 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123016
PNG
(US8742138, 1 | US8742138, 34)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-14(21)9-19-16(22)15-13-8-11(10-4-2-1-3-5-10)6-7-12(13)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123022
PNG
(US8742138, 7)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-3-1-2-9(6-11)10-4-5-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123023
PNG
(US8742138, 8)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-4-1-9(2-5-11)10-3-6-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123028
PNG
(US8742138, 13)
Show SMILES COc1ccc(cc1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO7/c1-26-12-5-2-10(3-6-12)11-4-7-13-14(8-11)16(19(25)27-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123029
PNG
(US8742138, 14)
Show SMILES Cc1cccc(c1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO6/c1-10-3-2-4-11(7-10)12-5-6-13-14(8-12)16(19(25)26-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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n/an/a 300n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123030
PNG
(US8742138, 15)
Show SMILES Cc1ccc(cc1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO6/c1-10-2-4-11(5-3-10)12-6-7-13-14(8-12)16(19(25)26-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123031
PNG
(US8742138, 16)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-13(21)9-19-16(22)15-14-11(10-5-2-1-3-6-10)7-4-8-12(14)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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n/an/a 350n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123032
PNG
(US8742138, 17)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccccc1Cl
Show InChI InChI=1S/C18H12ClNO6/c19-12-7-2-1-4-9(12)10-5-3-6-11-14(10)15(18(25)26-17(11)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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n/an/a 200n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123033
PNG
(US8742138, 18)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H12ClNO6/c19-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(25)26-17(12)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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n/an/a 90n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123034
PNG
(US8742138, 19)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClNO6/c19-10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(25)26-17(12)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123035
PNG
(US8742138, 20)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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n/an/a 100n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123036
PNG
(US8742138, 21)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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n/an/a 90n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123037
PNG
(US8742138, 22)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123039
PNG
(US8742138, 24)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2NO6/c19-11-5-4-8(6-12(11)20)9-2-1-3-10-14(9)15(18(26)27-17(10)25)16(24)21-7-13(22)23/h1-6,25H,7H2,(H,21,24)(H,22,23)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123016
PNG
(US8742138, 1 | US8742138, 34)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-14(21)9-19-16(22)15-13-8-11(10-4-2-1-3-5-10)6-7-12(13)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair