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13 similar compounds to monomer 123037

Wt: 423.2
BDBM123022
Wt: 423.2
BDBM123023
Wt: 369.3
BDBM123027
Wt: 353.3
BDBM123029
Wt: 339.2
BDBM123031
Wt: 373.7
BDBM123034
Wt: 407.2
BDBM123035
Wt: 407.2
BDBM123036
Wt: 423.2
BDBM123038
Wt: 369.3
BDBM123042
Wt: 369.3
BDBM123043
Wt: 353.3
BDBM123044
Wt: 353.3
BDBM123045

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 123022,123023,123027,123029,123031,123034,123035,123036,123038,123042,123043,123044,123045   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123022
PNG
(US8742138, 7)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-3-1-2-9(6-11)10-4-5-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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n/an/a 150n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123023
PNG
(US8742138, 8)
Show SMILES OC(=O)CNC(=O)c1c2cc(ccc2c(O)oc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-11-4-1-9(2-5-11)10-3-6-12-13(7-10)15(18(28)29-17(12)27)16(26)23-8-14(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123027
PNG
(US8742138, 12)
Show SMILES COc1cccc(c1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO7/c1-26-12-4-2-3-10(7-12)11-5-6-13-14(8-11)16(19(25)27-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123029
PNG
(US8742138, 14)
Show SMILES Cc1cccc(c1)-c1ccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c2c1
Show InChI InChI=1S/C19H15NO6/c1-10-3-2-4-11(7-10)12-5-6-13-14(8-12)16(19(25)26-18(13)24)17(23)20-9-15(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123031
PNG
(US8742138, 16)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccccc1
Show InChI InChI=1S/C18H13NO6/c20-13(21)9-19-16(22)15-14-11(10-5-2-1-3-6-10)7-4-8-12(14)17(23)25-18(15)24/h1-8,23H,9H2,(H,19,22)(H,20,21)
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n/an/a 350n/an/an/an/an/an/a



Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123034
PNG
(US8742138, 19)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H12ClNO6/c19-10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(25)26-17(12)24)16(23)20-8-13(21)22/h1-7,24H,8H2,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123045
PNG
(US8742138, 30)
Show SMILES Cc1ccc(cc1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO6/c1-10-5-7-11(8-6-10)12-3-2-4-13-15(12)16(19(25)26-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123036
PNG
(US8742138, 21)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
PDB
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123038
PNG
(US8742138, 23)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H12F3NO7/c20-19(21,22)30-10-6-4-9(5-7-10)11-2-1-3-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
PDB
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123042
PNG
(US8742138, 27)
Show SMILES COc1cccc(c1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO7/c1-26-11-5-2-4-10(8-11)12-6-3-7-13-15(12)16(19(25)27-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
PDB
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123043
PNG
(US8742138, 28)
Show SMILES COc1ccc(cc1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO7/c1-26-11-7-5-10(6-8-11)12-3-2-4-13-15(12)16(19(25)27-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
PDB
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123044
PNG
(US8742138, 29)
Show SMILES Cc1cccc(c1)-c1cccc2c(O)oc(=O)c(C(=O)NCC(O)=O)c12
Show InChI InChI=1S/C19H15NO6/c1-10-4-2-5-11(8-10)12-6-3-7-13-15(12)16(19(25)26-18(13)24)17(23)20-9-14(21)22/h2-8,24H,9H2,1H3,(H,20,23)(H,21,22)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair
Hypoxia-inducible factor (HIF-PH2)


(Rattus norvegicus (Rat))
BDBM123035
PNG
(US8742138, 20)
Show SMILES OC(=O)CNC(=O)c1c2c(cccc2c(O)oc1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H12F3NO6/c20-19(21,22)10-4-1-3-9(7-10)11-5-2-6-12-14(11)15(18(28)29-17(12)27)16(26)23-8-13(24)25/h1-7,27H,8H2,(H,23,26)(H,24,25)
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Betta Pharmaceuticals Co., Ltd.

US Patent


Assay Description
HIF-PHD2 activity was measured using homogeneous TR-FRET technology (see also, US2008/004817; Dao J H et al., Anal Biochem. 2009, 384:213-23). To eac...


US Patent US8742138 (2014)

More data for this
Ligand-Target Pair