BindingDB logo
myBDB logout

74 similar compounds to monomer 12557

Compile data set for download or QSAR
Wt: 423.9
BDBM12499
Wt: 437.9
BDBM12501
Wt: 451.9
BDBM12502
Wt: 437.9
BDBM12503
Wt: 451.9
BDBM12504
Wt: 465.9
BDBM12505
Wt: 491.0
BDBM12506
Wt: 505.0
BDBM12507
Wt: 488.9
BDBM12508
Wt: 503.0
BDBM12509
Wt: 503.0
BDBM12510
Wt: 517.0
BDBM12511
Wt: 531.0
BDBM12512
Wt: 528.0
BDBM12514
Wt: 481.9
BDBM12519
Displayed 1 to 15 (of 74 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 12499,12501,12502,12503,12504,12505,12506,12507,12508,12509,12510,12511,12512,12514,12519   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM12509
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)CC1CC1
Show InChI InChI=1S/C24H27ClN4O4S/c1-16(23(30)28(11-2-10-26)15-17-3-4-17)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,2-4,9,11-12,15H2,1H3/t16-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
3 -11.6n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12506
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)N(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C23H27ClN4O4S/c1-15(2)27(11-4-10-25)22(29)16(3)28-12-9-21(23(28)30)26-33(31,32)20-8-6-17-13-19(24)7-5-18(17)14-20/h5-8,13-16,21,26H,4,9,11-12H2,1-3H3/t16-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
5 -11.3n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12519
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)N(CCO)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C22H28ClN3O5S/c1-14(2)25(10-11-27)21(28)15(3)26-9-8-20(22(26)29)24-32(30,31)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,24,27H,8-11H2,1-3H3/t15-,20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
6n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12511
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCC1
Show InChI InChI=1S/C25H29ClN4O4S/c1-17(24(31)30(13-4-12-27)21-5-2-3-6-21)29-14-11-23(25(29)32)28-35(33,34)22-10-8-18-15-20(26)9-7-19(18)16-22/h7-10,15-17,21,23,28H,2-6,11,13-14H2,1H3/t17-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
11 -10.8n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12505
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CCN(C(C)C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C22H28ClN3O4S/c1-5-25(14(2)3)21(27)15(4)26-11-10-20(22(26)28)24-31(29,30)19-9-7-16-12-18(23)8-6-17(16)13-19/h6-9,12-15,20,24H,5,10-11H2,1-4H3/t15-,20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
11 -10.8n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12510
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCC1
Show InChI InChI=1S/C24H27ClN4O4S/c1-16(23(30)29(12-3-11-26)20-4-2-5-20)28-13-10-22(24(28)31)27-34(32,33)21-9-7-17-14-19(25)8-6-18(17)15-21/h6-9,14-16,20,22,27H,2-5,10,12-13H2,1H3/t16-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
15 -10.7n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12504
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)N(C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C21H26ClN3O4S/c1-13(2)24(4)20(26)14(3)25-10-9-19(21(25)27)23-30(28,29)18-8-6-15-11-17(22)7-5-16(15)12-18/h5-8,11-14,19,23H,9-10H2,1-4H3/t14-,19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
22 -10.4n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12514
PNG
((2S)-N-benzyl-2-[(3S)-3-[(6-chloronaphthalene-2-)s...)
Show SMILES CC(C)N(Cc1ccccc1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C27H30ClN3O4S/c1-18(2)31(17-20-7-5-4-6-8-20)26(32)19(3)30-14-13-25(27(30)33)29-36(34,35)24-12-10-21-15-23(28)11-9-22(21)16-24/h4-12,15-16,18-19,25,29H,13-14,17H2,1-3H3/t19-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
24 -10.4n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12502
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CCN(CC)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C21H26ClN3O4S/c1-4-24(5-2)20(26)14(3)25-11-10-19(21(25)27)23-30(28,29)18-9-7-15-12-17(22)8-6-16(15)13-18/h6-9,12-14,19,23H,4-5,10-11H2,1-3H3/t14-,19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
24 -10.4n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12501
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CCN(C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C20H24ClN3O4S/c1-4-23(3)19(25)13(2)24-10-9-18(20(24)26)22-29(27,28)17-8-6-14-11-16(21)7-5-15(14)12-17/h5-8,11-13,18,22H,4,9-10H2,1-3H3/t13-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
56 -9.89n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12508
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CC1
Show InChI InChI=1S/C23H25ClN4O4S/c1-15(22(29)28(11-2-10-25)19-6-7-19)27-12-9-21(23(27)30)26-33(31,32)20-8-4-16-13-18(24)5-3-17(16)14-20/h3-5,8,13-15,19,21,26H,2,6-7,9,11-12H2,1H3/t15-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
57 -9.88n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12512
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCCC1
Show InChI InChI=1S/C26H31ClN4O4S/c1-18(25(32)31(14-5-13-28)22-6-3-2-4-7-22)30-15-12-24(26(30)33)29-36(34,35)23-11-9-19-16-21(27)10-8-20(19)17-23/h8-11,16-18,22,24,29H,2-7,12,14-15H2,1H3/t18-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
73 -9.73n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12507
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)CN(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C24H29ClN4O4S/c1-16(2)15-28(11-4-10-26)23(30)17(3)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,4,9,11-12,15H2,1-3H3/t17-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
136 -9.36n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12499
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(C)C
Show InChI InChI=1S/C19H22ClN3O4S/c1-12(18(24)22(2)3)23-9-8-17(19(23)25)21-28(26,27)16-7-5-13-10-15(20)6-4-14(13)11-16/h4-7,10-12,17,21H,8-9H2,1-3H3/t12-,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
346 -8.81n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM12503
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)NC(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C20H24ClN3O4S/c1-12(2)22-19(25)13(3)24-9-8-18(20(24)26)23-29(27,28)17-7-5-14-10-16(21)6-4-15(14)11-17/h4-7,10-13,18,23H,8-9H2,1-3H3,(H,22,25)/t13-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.72E+3 -7.59n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair