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35 molecules are shown

Wt: 451.9
BDBM12502
Wt: 465.9
BDBM12505
Wt: 491.0
BDBM12506
Wt: 505.0
BDBM12507
Wt: 488.9
BDBM12508
Wt: 503.0
BDBM12509
Wt: 503.0
BDBM12510
Wt: 517.0
BDBM12511
Wt: 531.0
BDBM12512
Wt: 481.9
BDBM12519
Wt: 494.0
BDBM12520
Wt: 481.0
BDBM12522
Wt: 493.0
BDBM12523
Wt: 509.0
BDBM12524
Wt: 524.0
BDBM12525
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 12502,12505,12506,12507,12508,12509,12510,12511,12512,12519,12520,12522,12523,12524,12525   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (human))
BDBM12525
PNG
((2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-[(6-chl...)
Show SMILES CC(C)N(CCNC(N)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C23H30ClN5O5S/c1-14(2)28(11-9-26-23(25)32)21(30)15(3)29-10-8-20(22(29)31)27-35(33,34)19-7-5-16-12-18(24)6-4-17(16)13-19/h4-7,12-15,20,27H,8-11H2,1-3H3,(H3,25,26,32)/t15-,20-/m0/s1
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2n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12509
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)CC1CC1
Show InChI InChI=1S/C24H27ClN4O4S/c1-16(23(30)28(11-2-10-26)15-17-3-4-17)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,2-4,9,11-12,15H2,1H3/t16-,22-/m0/s1
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3 -11.6n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12522
PNG
((2S)-N-(2-aminoethyl)-2-[(3S)-3-[(6-chloronaphthal...)
Show SMILES CC(C)N(CCN)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C22H29ClN4O4S/c1-14(2)26(11-9-24)21(28)15(3)27-10-8-20(22(27)29)25-32(30,31)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,25H,8-11,24H2,1-3H3/t15-,20-/m0/s1
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4n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12506
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)N(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C23H27ClN4O4S/c1-15(2)27(11-4-10-25)22(29)16(3)28-12-9-21(23(28)30)26-33(31,32)20-8-6-17-13-19(24)7-5-18(17)14-20/h5-8,13-16,21,26H,4,9,11-12H2,1-3H3/t16-,21-/m0/s1
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5 -11.3n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12519
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)N(CCO)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C22H28ClN3O5S/c1-14(2)25(10-11-27)21(28)15(3)26-9-8-20(22(26)29)24-32(30,31)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,24,27H,8-11H2,1-3H3/t15-,20-/m0/s1
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6n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12520
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCO)CC1CC1
Show InChI InChI=1S/C23H28ClN3O5S/c1-15(22(29)26(10-11-28)14-16-2-3-16)27-9-8-21(23(27)30)25-33(31,32)20-7-5-17-12-19(24)6-4-18(17)13-20/h4-7,12-13,15-16,21,25,28H,2-3,8-11,14H2,1H3/t15-,21-/m0/s1
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7n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12505
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CCN(C(C)C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C22H28ClN3O4S/c1-5-25(14(2)3)21(27)15(4)26-11-10-20(22(26)28)24-31(29,30)19-9-7-16-12-18(23)8-6-17(16)13-19/h6-9,12-15,20,24H,5,10-11H2,1-4H3/t15-,20-/m0/s1
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11 -10.8n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12524
PNG
((2S)-N-(2-carbamoylethyl)-2-[(3S)-3-[(6-chloronaph...)
Show SMILES CC(C)N(CCC(N)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C23H29ClN4O5S/c1-14(2)27(11-9-21(25)29)22(30)15(3)28-10-8-20(23(28)31)26-34(32,33)19-7-5-16-12-18(24)6-4-17(16)13-19/h4-7,12-15,20,26H,8-11H2,1-3H3,(H2,25,29)/t15-,20-/m0/s1
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11n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12511
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCC1
Show InChI InChI=1S/C25H29ClN4O4S/c1-17(24(31)30(13-4-12-27)21-5-2-3-6-21)29-14-11-23(25(29)32)28-35(33,34)22-10-8-18-15-20(26)9-7-19(18)16-22/h7-10,15-17,21,23,28H,2-6,11,13-14H2,1H3/t17-,23-/m0/s1
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11 -10.8n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12523
PNG
((2S)-N-(2-aminoethyl)-2-[(3S)-3-[(6-chloronaphthal...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCN)CC1CC1
Show InChI InChI=1S/C23H29ClN4O4S/c1-15(22(29)27(11-9-25)14-16-2-3-16)28-10-8-21(23(28)30)26-33(31,32)20-7-5-17-12-19(24)6-4-18(17)13-20/h4-7,12-13,15-16,21,26H,2-3,8-11,14,25H2,1H3/t15-,21-/m0/s1
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15n/an/an/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12510
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCC1
Show InChI InChI=1S/C24H27ClN4O4S/c1-16(23(30)29(12-3-11-26)20-4-2-5-20)28-13-10-22(24(28)31)27-34(32,33)21-9-7-17-14-19(25)8-6-18(17)15-21/h6-9,14-16,20,22,27H,2-5,10,12-13H2,1H3/t16-,22-/m0/s1
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15 -10.7n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12502
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CCN(CC)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C21H26ClN3O4S/c1-4-24(5-2)20(26)14(3)25-11-10-19(21(25)27)23-30(28,29)18-9-7-15-12-17(22)8-6-16(15)13-18/h6-9,12-14,19,23H,4-5,10-11H2,1-3H3/t14-,19-/m0/s1
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24 -10.4n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12508
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CC1
Show InChI InChI=1S/C23H25ClN4O4S/c1-15(22(29)28(11-2-10-25)19-6-7-19)27-12-9-21(23(27)30)26-33(31,32)20-8-4-16-13-18(24)5-3-17(16)14-20/h3-5,8,13-15,19,21,26H,2,6-7,9,11-12H2,1H3/t15-,21-/m0/s1
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57 -9.88n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12512
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCCC1
Show InChI InChI=1S/C26H31ClN4O4S/c1-18(25(32)31(14-5-13-28)22-6-3-2-4-7-22)30-15-12-24(26(30)33)29-36(34,35)23-11-9-19-16-21(27)10-8-20(19)17-23/h8-11,16-18,22,24,29H,2-7,12,14-15H2,1H3/t18-,24-/m0/s1
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73 -9.73n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM12507
PNG
((2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamid...)
Show SMILES CC(C)CN(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O
Show InChI InChI=1S/C24H29ClN4O4S/c1-16(2)15-28(11-4-10-26)23(30)17(3)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,4,9,11-12,15H2,1-3H3/t17-,22-/m0/s1
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136 -9.36n/an/an/an/an/a7.825



GlaxoSmithKline



Assay Description
The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...


Bioorg Med Chem Lett 16: 5953-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.001
BindingDB Entry DOI: 10.7270/Q2CF9NB8
More data for this
Ligand-Target Pair